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The map label for this gene is trkH [H]

Identifier: 218711002

GI number: 218711002

Start: 3266293

End: 3267738

Strand: Direct

Name: trkH [H]

Synonym: VS_3131

Alternate gene names: 218711002

Gene position: 3266293-3267738 (Clockwise)

Preceding gene: 218711001

Following gene: 218711003

Centisome position: 99.0

GC content: 49.72

Gene sequence:

>1446_bases
ATGGTCAACTTTCGTCCGATATTATTAGTGATAGGGTTAGTGTTATCAAAACTCGCCCTTTTCATGTACATCCCTACATT
GGTTGCCTTTTTCACAGGCACCGGTGGCTTCCTCGAGTTTGGTCAATCGGTAGTGATCACGCACATTGTGGCGTTCATCT
GCTTGAGCTTGGGCCGCTCCGCTAAGTTCCGACTTGGGGTGCGGGACATGTTCCTTATCACCTCTTTGGTTTGGACAATT
GCCAGCGCCTTTGCCGCCCTGCCATTTGTCTTCATTAACCACATCAGCTTTACAGATGCCTACTTCGAAACCATGTCAGG
TATCACCACGACAGGCTCAACCGTATTAAGCGGCTTAGACAGCATGGCACCAAGTATTCTGTTGTGGCGTTCTATACTGC
AATGGTTAGGCGGTATCGGCTTTATCGTGATGGCGGTAGCGGTTCTACCAATGCTCAACGTCGGTGGCATGCGCCTGTTC
CAAACTGAATCATCCGATTGGTCAGATAAAAGTAGCCCACGAGCGAAAACAGTCGCGAAGAACATCGTGGCGGTTTATCT
GGTTCTGACTGGTTTATGCATCATTAGCTATTTGTTTGCAGGCATGGGCATCTTTGACGCGATCAATCACGCGTTCACAA
CACTGTCGACGGGGGGTTACTCAACCTCAGATGGATCGATGAACCACTTCTCCAACAGTGCTCACTGGGTGGGAACCCTG
TTCATGTTCCTTGGCGGCCTGCCGTTCTTACTGTTTGTTAGCGCACTGCGAGGCCGAAAACTCTCAATCCTCTACAAAGA
CGCGCAAGTGAGAGGTTTCACGTACCTGTTCTTGGTCACCAGCGCCGTAATATCAACATGGTTGGTGGTTAGAGATGGCT
ACACTGTTATGGATGCGATGCGTGTTTCGATGTTCAACATCGTATCAGTCGTCACCACAACCGGTTTTGGCCTAGAAGAC
TTCACCGCCTGGGGTGCACTGCCAACCACCTTGTTTGCATTCCTAATGATGGCGGGCGCTTGCTCGGGTTCAACCTCTGG
CGGTATCAAAATCTTCCGCTTCCAGATCGCGATGACCATGCTCCACAAACAAATGATGAAGCTCATTCACCCATCAGGCG
TGTTTGTTCAACGCTACAATCAGCGACCTGTGAATGACGATATTGTGCGTTCACTCGTGGCATTTGGTTTGATGTTCTTT
ATTACGATTATCTTAATTGCTGGTGGTTTGAGTGCGATGGGGTTAGACCCAATAACAAGCATCTCAGGCGCTATCACAGC
CGTTGCCAACGTGGGCCCAGGCATGGGCAGCGTGATCGGTCCAACCGGGAACTTTGCTCCACTGCCAGACGCCGCTAAAT
GGTTATTAAGTTTAGGCATGTTGATGGGCCGACTTGAGATACTAACGCTCATTGTTCTATTTTTCCCAGCCTTTTGGCGA
CGCTAA

Upstream 100 bases:

>100_bases
CGAGCCCGTTCTTCTTATAGCCTTGTTCTCGTAAGCTTCTTCTCGCAGCTTTCTTCTTGTGAGAACGACGCTCCGGCTCA
AAGCGATGGTCAATTAAGCT

Downstream 100 bases:

>100_bases
TTACGCGAATATTTAAGGAAACACAGATGAAATCATACGTACTTCTCGCTAGCGCATTGCTCGCAAACTCAGTATTCGTA
AGTTCTGCCTTTGCTGATCA

Product: potassium uptake protein TrkH

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MVNFRPILLVIGLVLSKLALFMYIPTLVAFFTGTGGFLEFGQSVVITHIVAFICLSLGRSAKFRLGVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGITTTGSTVLSGLDSMAPSILLWRSILQWLGGIGFIVMAVAVLPMLNVGGMRLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCIISYLFAGMGIFDAINHAFTTLSTGGYSTSDGSMNHFSNSAHWVGTL
FMFLGGLPFLLFVSALRGRKLSILYKDAQVRGFTYLFLVTSAVISTWLVVRDGYTVMDAMRVSMFNIVSVVTTTGFGLED
FTAWGALPTTLFAFLMMAGACSGSTSGGIKIFRFQIAMTMLHKQMMKLIHPSGVFVQRYNQRPVNDDIVRSLVAFGLMFF
ITIILIAGGLSAMGLDPITSISGAITAVANVGPGMGSVIGPTGNFAPLPDAAKWLLSLGMLMGRLEILTLIVLFFPAFWR
R

Sequences:

>Translated_481_residues
MVNFRPILLVIGLVLSKLALFMYIPTLVAFFTGTGGFLEFGQSVVITHIVAFICLSLGRSAKFRLGVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGITTTGSTVLSGLDSMAPSILLWRSILQWLGGIGFIVMAVAVLPMLNVGGMRLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCIISYLFAGMGIFDAINHAFTTLSTGGYSTSDGSMNHFSNSAHWVGTL
FMFLGGLPFLLFVSALRGRKLSILYKDAQVRGFTYLFLVTSAVISTWLVVRDGYTVMDAMRVSMFNIVSVVTTTGFGLED
FTAWGALPTTLFAFLMMAGACSGSTSGGIKIFRFQIAMTMLHKQMMKLIHPSGVFVQRYNQRPVNDDIVRSLVAFGLMFF
ITIILIAGGLSAMGLDPITSISGAITAVANVGPGMGSVIGPTGNFAPLPDAAKWLLSLGMLMGRLEILTLIVLFFPAFWR
R
>Mature_481_residues
MVNFRPILLVIGLVLSKLALFMYIPTLVAFFTGTGGFLEFGQSVVITHIVAFICLSLGRSAKFRLGVRDMFLITSLVWTI
ASAFAALPFVFINHISFTDAYFETMSGITTTGSTVLSGLDSMAPSILLWRSILQWLGGIGFIVMAVAVLPMLNVGGMRLF
QTESSDWSDKSSPRAKTVAKNIVAVYLVLTGLCIISYLFAGMGIFDAINHAFTTLSTGGYSTSDGSMNHFSNSAHWVGTL
FMFLGGLPFLLFVSALRGRKLSILYKDAQVRGFTYLFLVTSAVISTWLVVRDGYTVMDAMRVSMFNIVSVVTTTGFGLED
FTAWGALPTTLFAFLMMAGACSGSTSGGIKIFRFQIAMTMLHKQMMKLIHPSGVFVQRYNQRPVNDDIVRSLVAFGLMFF
ITIILIAGGLSAMGLDPITSISGAITAVANVGPGMGSVIGPTGNFAPLPDAAKWLLSLGMLMGRLEILTLIVLFFPAFWR
R

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI48994987, Length=490, Percent_Identity=34.2857142857143, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1787626, Length=432, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 52151; Mature: 52151

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]