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The map label for this gene is aroE

Identifier: 218710989

GI number: 218710989

Start: 3254104

End: 3254934

Strand: Reverse

Name: aroE

Synonym: VS_3117

Alternate gene names: 218710989

Gene position: 3254934-3254104 (Counterclockwise)

Preceding gene: 218710990

Following gene: 218710988

Centisome position: 98.66

GC content: 45.13

Gene sequence:

>831_bases
ATGACACAGCAAGTAGATCGTTATGCCGTTTTCGGTAACCCTATTGGGCAAAGCAAATCGCCATTCATTCACACATTATT
TGCTCGCCAAACCAGCCAACAACTTACCTATTCAGCATTACAGCCAGAGCATGGTGAATTTATCACTGCGGCCAAAGCCT
TTTTCAGCGAAGGTGGTCGAGGATGTAACGTCACAGCACCTTTTAAAGAAGATGCGTATCAGTTTGCCAATCGCCTAACT
GAGAGGGCTGAACTGGCCGGTGCCGTAAATACCCTTAAGAAGTTAGATGACGGAGAAATCATTGGTGATAACACCGATGG
TGAGGGCTTAGTTCAAGACCTGCTTCAACATCAAGTCACGCTAAAAGGAGCACGTGTTCTTCTTCTTGGTGCTGGTGGTG
CTGCGAGAGGAGTGATTCAACCTCTTCTCGACCAAAAGCCACAACAGCTGGTGGTCGCTAATCGAACCAGCTCAAAGGCT
GAACTTCTGGCTGAGATGTTTTCGTCGCATGGAAATATCAAAGGTATAGGGCTAAGTGATGTTAATGAAGGCTTTGATGT
CATTATTAACTCGACCTCGTCTGGCCTAAGTGGGCAGCTTCCTGAAGTGTCTGACGTTATTTTCAATTCTAATAGTACCG
TTTATGACATGGTTTATGGATCGGGAACCACGGTATTCAATCAATGGGCATTAGATAATGGTGTTCATGCTGCTTATGAT
GGTTTGGGTATGTTAGTGGGGCAGGCAGCAGAGAGCTTTATGCTTTGGCGTGGTCTTCGTCCGGGAACAAAACAGATTTT
AAGAGAATTACGTAAAAACCTAGAGATGTAA

Upstream 100 bases:

>100_bases
CTACCTAAAGCCTCGAGTTTGGTAGTTCTTCCTTCCTTATAGGGATAGTGATAGGGTCATCTATATAGATGACCCTTTTT
TATTTCTGTTAGGTAAGGAT

Downstream 100 bases:

>100_bases
TGAGGTATTTATAAAAAATGAATCAATCAATTATATTTCCTGATATCCAAGATTGGGATGAAGAGAATCAATCAATCACC
TTCCCAGCACAACAGTCGGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGRGCNVTAPFKEDAYQFANRLT
ERAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVTLKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKA
ELLAEMFSSHGNIKGIGLSDVNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYD
GLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM

Sequences:

>Translated_276_residues
MTQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGRGCNVTAPFKEDAYQFANRLT
ERAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVTLKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKA
ELLAEMFSSHGNIKGIGLSDVNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYD
GLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM
>Mature_275_residues
TQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGRGCNVTAPFKEDAYQFANRLTE
RAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVTLKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKAE
LLAEMFSSHGNIKGIGLSDVNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYDG
LGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=47.4264705882353, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1787983, Length=278, Percent_Identity=28.4172661870504, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=282, Percent_Identity=26.9503546099291, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_VIBSL (B7VMW2)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002418610.1
- ProteinModelPortal:   B7VMW2
- GeneID:   7162556
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_3117
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- ProtClustDB:   PRK00258
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29826; Mature: 29695

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: ACT_SITE 69-69

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGR
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
GCNVTAPFKEDAYQFANRLTERAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHH
LKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKAELLAEMFSSHGNIKGIGLSD
HCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEECCCCC
VNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYD
CCCCCEEEEECCCCCCCCCCCCHHHHEECCCCEEEEEEECCCCCEEEHHHHCCCCHHHHH
GLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQQVDRYAVFGNPIGQSKSPFIHTLFARQTSQQLTYSALQPEHGEFITAAKAFFSEGGR
CCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
GCNVTAPFKEDAYQFANRLTERAELAGAVNTLKKLDDGEIIGDNTDGEGLVQDLLQHQVT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHH
LKGARVLLLGAGGAARGVIQPLLDQKPQQLVVANRTSSKAELLAEMFSSHGNIKGIGLSD
HCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEECCCCC
VNEGFDVIINSTSSGLSGQLPEVSDVIFNSNSTVYDMVYGSGTTVFNQWALDNGVHAAYD
CCCCCEEEEECCCCCCCCCCCCHHHHEECCCCEEEEEEECCCCCEEEHHHHCCCCHHHHH
GLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEM
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA