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The map label for this gene is mco [H]

Identifier: 218710986

GI number: 218710986

Start: 3245163

End: 3246545

Strand: Reverse

Name: mco [H]

Synonym: VS_3101

Alternate gene names: 218710986

Gene position: 3246545-3245163 (Counterclockwise)

Preceding gene: 218710988

Following gene: 218710985

Centisome position: 98.4

GC content: 42.66

Gene sequence:

>1383_bases
ATGGATATTTCCCGTCGTAAGTTTATTCAATCATCTCTCGCTATATCTGCACTAACTGTTTTACCCGCTTGTTCTATGAA
GCAGTCTGTTGATGGTCAAGGTAAGTATGTTTATGACTTAACTGCTGAACCTTCAATGGCTGAATTAGTCGTGGGATTTG
ATACCAATGTTTTAGCCTTTAATGGACAGATTCCAGCTCCGACGATTCGATGTCGACAGGGTGAAAAGGTCACAATTCGT
TTTACGAATAAGCTATCAGAGCCGACGACTATTCATTGGCATGGCTTAAGAATTCCTATCGAAATGGATGGAGTTCCCTT
TTTAAGTCAGCCACCAATCATGCCAGGTGAAACATTCATTTATGAGTTTACGCCGCCAGATGCCGGCACATTTTGGTATC
ACCCACATATGAATAGCGTTAAACAACTTGGGATGGGGTTGGTTGGTCTTATTATCGTAGAAGAAAGCACTCCCGTGCAG
TTTGACGAAGAACACGCATTAATGCTTAAACATTGGCATATCGACAAGCAAGGTCAATGGAAAGACTTAATGATTCCACG
ACTCAGTGCTCGTATGGGCACTCCTGGTGAGTGGAGTAGTGTTAATGGAGTTCATGAACCCGTATACCAATTAAAGCAGC
ACGCAACGACTCGACTGCGGATTGCCAATGTCGATAATACGATCACTTATCCTATTGCTATCGAAGGGGCTGAGGCATGG
GTGATTGCCATTGATGGTAACCCTGTGAAAACGCCTTATAAACTGACTCAACATAAAATTGGTCCGGGTATGCGTGTTGA
TATCGGACTGATCGCTCCTAAAGCTAGGGAGCGAGTTAACGTTCTCCAAATGAAGGGGCGTTTCCCATTTTCTTTGTGTG
AATTTGAAGTCGTAGATTCAGCATTTACTCAAGAACGGGTGTTGCCATTATTACCATTGAATCCAGTACCTAACCTAGAT
CTTGCTAATGCTGAAGAGATCGATTTCGTGTTCGAGTGGGAGGGTGCAGTTTCACCTGTATCTAAAGATGGTAAATCGAT
GCCTAAATTTTGGCTTACTAATAAACGAGCGTGGGAGGGGATGAGCAAAGACAATATCCCTGAGCCGTTGGCGACTTTAG
ATCTAGGTAAAACTTACATATTCGATCTTAAGAACGTCACTCAATATCATCACCCGATTCATATTCATGGTCATACATTC
ACTGTATTGGAACTTGATGGTAAAAAAATTGAAGAACCTTTCCATACCGATACCGTGCTACTTGGAAAAAACGGCCGAGC
GAAAGCCGCATTTGTTGCCGACAACCCAGGACGTTGGATGTATCACTGTCATGTTATAGAACACATGAAAACGGGTTTAA
TGGGATATATCGAAGTTAAGTGA

Upstream 100 bases:

>100_bases
CTCTTTTATAAACAACCAACAGCACAATCCCCACTTCTTTATGAGAATTATTCTCAATATTTTGTTACATTTTGGTCGTT
ATTACTAAAAGGCAACAAAT

Downstream 100 bases:

>100_bases
CACCTGTAACGTTTAATATTTGCGCATGCATTCTTAGTTTCTACCCTCGCTTTTATCGGCGTTAAAGCTAGAATATAGGG
ATTATTGTTTGGGAGGGTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDISRRKFIQSSLAISALTVLPACSMKQSVDGQGKYVYDLTAEPSMAELVVGFDTNVLAFNGQIPAPTIRCRQGEKVTIR
FTNKLSEPTTIHWHGLRIPIEMDGVPFLSQPPIMPGETFIYEFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVEESTPVQ
FDEEHALMLKHWHIDKQGQWKDLMIPRLSARMGTPGEWSSVNGVHEPVYQLKQHATTRLRIANVDNTITYPIAIEGAEAW
VIAIDGNPVKTPYKLTQHKIGPGMRVDIGLIAPKARERVNVLQMKGRFPFSLCEFEVVDSAFTQERVLPLLPLNPVPNLD
LANAEEIDFVFEWEGAVSPVSKDGKSMPKFWLTNKRAWEGMSKDNIPEPLATLDLGKTYIFDLKNVTQYHHPIHIHGHTF
TVLELDGKKIEEPFHTDTVLLGKNGRAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK

Sequences:

>Translated_460_residues
MDISRRKFIQSSLAISALTVLPACSMKQSVDGQGKYVYDLTAEPSMAELVVGFDTNVLAFNGQIPAPTIRCRQGEKVTIR
FTNKLSEPTTIHWHGLRIPIEMDGVPFLSQPPIMPGETFIYEFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVEESTPVQ
FDEEHALMLKHWHIDKQGQWKDLMIPRLSARMGTPGEWSSVNGVHEPVYQLKQHATTRLRIANVDNTITYPIAIEGAEAW
VIAIDGNPVKTPYKLTQHKIGPGMRVDIGLIAPKARERVNVLQMKGRFPFSLCEFEVVDSAFTQERVLPLLPLNPVPNLD
LANAEEIDFVFEWEGAVSPVSKDGKSMPKFWLTNKRAWEGMSKDNIPEPLATLDLGKTYIFDLKNVTQYHHPIHIHGHTF
TVLELDGKKIEEPFHTDTVLLGKNGRAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
>Mature_460_residues
MDISRRKFIQSSLAISALTVLPACSMKQSVDGQGKYVYDLTAEPSMAELVVGFDTNVLAFNGQIPAPTIRCRQGEKVTIR
FTNKLSEPTTIHWHGLRIPIEMDGVPFLSQPPIMPGETFIYEFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVEESTPVQ
FDEEHALMLKHWHIDKQGQWKDLMIPRLSARMGTPGEWSSVNGVHEPVYQLKQHATTRLRIANVDNTITYPIAIEGAEAW
VIAIDGNPVKTPYKLTQHKIGPGMRVDIGLIAPKARERVNVLQMKGRFPFSLCEFEVVDSAFTQERVLPLLPLNPVPNLD
LANAEEIDFVFEWEGAVSPVSKDGKSMPKFWLTNKRAWEGMSKDNIPEPLATLDLGKTYIFDLKNVTQYHHPIHIHGHTF
TVLELDGKKIEEPFHTDTVLLGKNGRAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=538, Percent_Identity=23.7918215613383, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789394, Length=298, Percent_Identity=25.1677852348993, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321067, Length=472, Percent_Identity=24.7881355932203, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323703, Length=199, Percent_Identity=37.1859296482412, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320714, Length=119, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24650186, Length=109, Percent_Identity=40.3669724770642, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI18859919, Length=131, Percent_Identity=35.8778625954198, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330000, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585842, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360167, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329998, Length=228, Percent_Identity=30.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574104, Length=133, Percent_Identity=33.0827067669173, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51803; Mature: 51803

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISRRKFIQSSLAISALTVLPACSMKQSVDGQGKYVYDLTAEPSMAELVVGFDTNVLAF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEE
NGQIPAPTIRCRQGEKVTIRFTNKLSEPTTIHWHGLRIPIEMDGVPFLSQPPIMPGETFI
CCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCEEE
YEFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVEESTPVQFDEEHALMLKHWHIDKQGQW
EEECCCCCCEEEECCCHHHHHHHCCCEEEEEEEECCCCCEECCCCEEEEEEEECCCCCCC
KDLMIPRLSARMGTPGEWSSVNGVHEPVYQLKQHATTRLRIANVDNTITYPIAIEGAEAW
HHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEECCCEE
VIAIDGNPVKTPYKLTQHKIGPGMRVDIGLIAPKARERVNVLQMKGRFPFSLCEFEVVDS
EEEECCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHHEEEEEECCCCCCCHHHHHHHHH
AFTQERVLPLLPLNPVPNLDLANAEEIDFVFEWEGAVSPVSKDGKSMPKFWLTNKRAWEG
HHHHHCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHCC
MSKDNIPEPLATLDLGKTYIFDLKNVTQYHHPIHIHGHTFTVLELDGKKIEEPFHTDTVL
CCCCCCCCCHHHHCCCCEEEEECHHHHHHCCCEEECCCEEEEEEECCCCCCCCCCCCEEE
LGKNGRAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
ECCCCCCEEEEEECCCCCEEEEEEEHHHHHCCCEEEEEEC
>Mature Secondary Structure
MDISRRKFIQSSLAISALTVLPACSMKQSVDGQGKYVYDLTAEPSMAELVVGFDTNVLAF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEE
NGQIPAPTIRCRQGEKVTIRFTNKLSEPTTIHWHGLRIPIEMDGVPFLSQPPIMPGETFI
CCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCEEE
YEFTPPDAGTFWYHPHMNSVKQLGMGLVGLIIVEESTPVQFDEEHALMLKHWHIDKQGQW
EEECCCCCCEEEECCCHHHHHHHCCCEEEEEEEECCCCCEECCCCEEEEEEEECCCCCCC
KDLMIPRLSARMGTPGEWSSVNGVHEPVYQLKQHATTRLRIANVDNTITYPIAIEGAEAW
HHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEECCCEE
VIAIDGNPVKTPYKLTQHKIGPGMRVDIGLIAPKARERVNVLQMKGRFPFSLCEFEVVDS
EEEECCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHHEEEEEECCCCCCCHHHHHHHHH
AFTQERVLPLLPLNPVPNLDLANAEEIDFVFEWEGAVSPVSKDGKSMPKFWLTNKRAWEG
HHHHHCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHCC
MSKDNIPEPLATLDLGKTYIFDLKNVTQYHHPIHIHGHTFTVLELDGKKIEEPFHTDTVL
CCCCCCCCCHHHHCCCCEEEEECHHHHHHCCCEEECCCEEEEEEECCCCCCCCCCCCEEE
LGKNGRAKAAFVADNPGRWMYHCHVIEHMKTGLMGYIEVK
ECCCCCCEEEEEECCCCCEEEEEEEHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA