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The map label for this gene is lysA [H]

Identifier: 218710945

GI number: 218710945

Start: 3195174

End: 3196427

Strand: Reverse

Name: lysA [H]

Synonym: VS_3048

Alternate gene names: 218710945

Gene position: 3196427-3195174 (Counterclockwise)

Preceding gene: 218710946

Following gene: 218710944

Centisome position: 96.88

GC content: 47.29

Gene sequence:

>1254_bases
TTGGATTACTTCAACTATCAGGAAGATGGCCAGCTTTGGGCTGAGGACGTCGCACTTTCACAACTAGCAGAGCAATATGG
TACACCGCTGTATGTATATTCTCGTGCCACATTAGAACGTCACTGGAACGCGTTTGACTCATCGGTAGGTGAGCACCCGC
ATTTGGTGTGTTACGCCGTTAAAGCTAACTCGAATCTAGGCGTGTTGAATACCTTAGCTCGTTTGGGTTCTGGTTTTGAC
ATCGTTTCTGGTGGTGAGCTAGAGCGTGTGGTTGCTGCAGGTGGCGATCCGGCGAAAGTTGTTTTCTCTGGTGTCGGCAA
AACAGCCGCAGAAATGAAGCGAGCGCTTGAGTTGAACATTAAATGTTTCAACGTAGAGTCTGAGCCAGAACTGGAGCGAC
TGAATAAAGTGGCCGGTGAGCTTGGAGTTAAAGCGCCGATTTCACTGAGAATCAACCCTGATGTTGATGCTAATACTCAC
CCTTATATCTCTACGGGCCTGCGTGATAACAAGTTTGGTATCGCCTTCGATCGTGCTCCTGCTGTTTATGCGTTTGCTAA
AACACTCGATAACTTGTCTATCCATGGTATTGATTGCCATATCGGCTCTCAGTTAACGGATATCGAACCTTTCATCGATG
CCACTGATCGCTTGCTTGCGTTGATCGATCAACTACGAGCTAACGATATCAACATCAAGCATCTTGATGTTGGCGGTGGT
TTGGGGGTGGTTTATCGTGATGAATTACCACCACAGCCCTCTGACTATGCGAAAGCCTTGTTGGCTCGCCTAGACAATCA
TTCTGATCTAGAGCTGATTTTCGAGCCAGGAAGAGCGATTGCGGCTAACGCTGGTGTATTATTAACAAAAGTCGAGTTCC
TTAAGCCAACAGAGCATAAGAACTTTGCCATTATCGATGCGGCAATGAACGACCTGATGCGCCCTGCACTTTACCAAGCT
TGGCAAGATATTGTTCCAGTTAGCCCGCGTCAGGGTGAAGCTGTGACTTACGATTTAGTTGGCCCTATATGTGAAACGGG
TGACTTCCTAGGTAAAGATCGTGACCTTGTTCTTGAAGAGGGCGATTTATTGGCTGTTCGTTCAGCAGGTGCTTATGGCT
TCGCTATGTCATCTAACTACAACACTCGTTCGCGTGCGGCAGAAGTGATGGTTGATGGCGATAAAACTCATTTGGTTCGT
CAGCGTGAAGAGCTTACGAGTCTGTGGGAACTTGAAAACATTCTTCCGGAGTAA

Upstream 100 bases:

>100_bases
GTCAAACGGGTCCTTTGTATGATCCTGATGAAGTTCAACAGACTGAACAATCACAATAAGTGAAACACGCAGAAATCGTT
ATTTATAAGGGATAAGAACT

Downstream 100 bases:

>100_bases
TTTTAAGCGTTATGCACTTCCACTTTTCTAAAATGCATGGTTTGGGCAATGATTTCATGGTCGTGGACTGCATTACTCAA
AATATTTTCTTCTCTCCAGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDYFNYQEDGQLWAEDVALSQLAEQYGTPLYVYSRATLERHWNAFDSSVGEHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVVAAGGDPAKVVFSGVGKTAAEMKRALELNIKCFNVESEPELERLNKVAGELGVKAPISLRINPDVDANTH
PYISTGLRDNKFGIAFDRAPAVYAFAKTLDNLSIHGIDCHIGSQLTDIEPFIDATDRLLALIDQLRANDINIKHLDVGGG
LGVVYRDELPPQPSDYAKALLARLDNHSDLELIFEPGRAIAANAGVLLTKVEFLKPTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVSPRQGEAVTYDLVGPICETGDFLGKDRDLVLEEGDLLAVRSAGAYGFAMSSNYNTRSRAAEVMVDGDKTHLVR
QREELTSLWELENILPE

Sequences:

>Translated_417_residues
MDYFNYQEDGQLWAEDVALSQLAEQYGTPLYVYSRATLERHWNAFDSSVGEHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVVAAGGDPAKVVFSGVGKTAAEMKRALELNIKCFNVESEPELERLNKVAGELGVKAPISLRINPDVDANTH
PYISTGLRDNKFGIAFDRAPAVYAFAKTLDNLSIHGIDCHIGSQLTDIEPFIDATDRLLALIDQLRANDINIKHLDVGGG
LGVVYRDELPPQPSDYAKALLARLDNHSDLELIFEPGRAIAANAGVLLTKVEFLKPTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVSPRQGEAVTYDLVGPICETGDFLGKDRDLVLEEGDLLAVRSAGAYGFAMSSNYNTRSRAAEVMVDGDKTHLVR
QREELTSLWELENILPE
>Mature_417_residues
MDYFNYQEDGQLWAEDVALSQLAEQYGTPLYVYSRATLERHWNAFDSSVGEHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVVAAGGDPAKVVFSGVGKTAAEMKRALELNIKCFNVESEPELERLNKVAGELGVKAPISLRINPDVDANTH
PYISTGLRDNKFGIAFDRAPAVYAFAKTLDNLSIHGIDCHIGSQLTDIEPFIDATDRLLALIDQLRANDINIKHLDVGGG
LGVVYRDELPPQPSDYAKALLARLDNHSDLELIFEPGRAIAANAGVLLTKVEFLKPTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVSPRQGEAVTYDLVGPICETGDFLGKDRDLVLEEGDLLAVRSAGAYGFAMSSNYNTRSRAAEVMVDGDKTHLVR
QREELTSLWELENILPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=25.1428571428571, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789203, Length=432, Percent_Identity=29.8611111111111, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=354, Percent_Identity=24.8587570621469, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=378, Percent_Identity=24.0740740740741, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586474, Length=392, Percent_Identity=23.9795918367347, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45767; Mature: 45767

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFNYQEDGQLWAEDVALSQLAEQYGTPLYVYSRATLERHWNAFDSSVGEHPHLVCYAV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEE
KANSNLGVLNTLARLGSGFDIVSGGELERVVAAGGDPAKVVFSGVGKTAAEMKRALELNI
ECCCCCHHHHHHHHHCCCCEEECCCCEEEHEECCCCCHHHHEECCCHHHHHHHHHHEEEE
KCFNVESEPELERLNKVAGELGVKAPISLRINPDVDANTHPYISTGLRDNKFGIAFDRAP
EEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCEEEECCCC
AVYAFAKTLDNLSIHGIDCHIGSQLTDIEPFIDATDRLLALIDQLRANDINIKHLDVGGG
HHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LGVVYRDELPPQPSDYAKALLARLDNHSDLELIFEPGRAIAANAGVLLTKVEFLKPTEHK
EEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCEEEEEEECCCCCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVSPRQGEAVTYDLVGPICETGDFLGKDRDLVLEE
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHCCHHCCCCCCEEEEC
GDLLAVRSAGAYGFAMSSNYNTRSRAAEVMVDGDKTHLVRQREELTSLWELENILPE
CCEEEEECCCCEEEEECCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFNYQEDGQLWAEDVALSQLAEQYGTPLYVYSRATLERHWNAFDSSVGEHPHLVCYAV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEE
KANSNLGVLNTLARLGSGFDIVSGGELERVVAAGGDPAKVVFSGVGKTAAEMKRALELNI
ECCCCCHHHHHHHHHCCCCEEECCCCEEEHEECCCCCHHHHEECCCHHHHHHHHHHEEEE
KCFNVESEPELERLNKVAGELGVKAPISLRINPDVDANTHPYISTGLRDNKFGIAFDRAP
EEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCEEEECCCC
AVYAFAKTLDNLSIHGIDCHIGSQLTDIEPFIDATDRLLALIDQLRANDINIKHLDVGGG
HHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LGVVYRDELPPQPSDYAKALLARLDNHSDLELIFEPGRAIAANAGVLLTKVEFLKPTEHK
EEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCEEEEEEECCCCCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVSPRQGEAVTYDLVGPICETGDFLGKDRDLVLEE
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHCCHHCCCCCCEEEEC
GDLLAVRSAGAYGFAMSSNYNTRSRAAEVMVDGDKTHLVRQREELTSLWELENILPE
CCEEEEECCCCEEEEECCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]