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The map label for this gene is cpxA [H]

Identifier: 218710834

GI number: 218710834

Start: 3068191

End: 3069570

Strand: Direct

Name: cpxA [H]

Synonym: VS_2917

Alternate gene names: 218710834

Gene position: 3068191-3069570 (Clockwise)

Preceding gene: 218710833

Following gene: 218710835

Centisome position: 93.0

GC content: 47.32

Gene sequence:

>1380_bases
ATGCGTATCCCTAAAATCACCAGCTTATATGGACGTATCTTTGCTATCTTTTGGTTCACCATGTTACTGGTGCTTTTGTC
GGTACTGTCACTTCCCCATTTAGACCCGCGAGTGGCGCGCGATGTGCCTGCCGATCATCTCGATAAACTCGAACGTATCG
CTAAATTCACAGAAAAGCGCTACGCCAAAGAATCTAACCTGGGAAAAATAGTGTTCCAACTTGAGGCACCGCGTAGCCGC
AAGGATTCTCGTGCTCGTATTTACCTAACCGACCTTGAAGGCGCGGTCCTTACATCGAAAAGACACTCAAATTACAAACT
TAAAGCGATTCGTAATTTTGTTACCTCGATAGATAACCCTGAATTACCCAAGCAAAAGTTATACGGACATTACATGGTAG
CAGGGCCAGTCCCTATCACACTCGCTGGAGAAGAATTACTGATGTATGCCGGAGTAAAATGGAACCAACCTCCTCCATTT
TTGCTGCGCTTATTTGATAGACCTTTACAGTTATTGCTTGCGGTAATGCTAGCAAGTACCCCACTGCTATTATGGTTAGC
TTGGGCATTGAGCCAACCTGCTCGTAGGCTTGAACGCGCAGCACAACGTGTGGCGAAAGGTCAGTTTGAGGTCGATCCCA
CACTCGAAAAAGGCACCTCAGAATTCAGACAAGCGGGTGAGAGCTTTAACCAGATGGTCGAAGCGGTTAATCAGATGATT
TCGGGGCAACAACGCCTACTTTCAGATATCTCACACGAGCTACGATCGCCATTGACCCGCCTTCGCATGGCCAATGCTCT
TGCGATTCGTAAACAGGGTGAGAGCCAAGAGTTAGAACGTATTGATATGGAAGCTCAGCGATTAGAGCAAATGATCAGTG
AGCTACTGACGCTATCACGCATGCAGGTCGACAGCCATATTACTCGTGAGGTTCAGCCTATTTCGAGCTTATGGGAAGAG
ATTTTAAAAGATGCAGAATTTGAAGCTGAACAGATGGGTAAATTACTGACGTTTTCGGAGATCCCAGACCGTTCTATTTC
GGGTAATCCTAAGCTGCTGATGAGTGCCTTGGACAATATTACGCGTAATGCCATCTATTACGGGAAAGACCAAGTCGATG
TGCAATTCGATGTTGTCCAAGATCGGCTGACGATTTGCGTCAATGACAACGGTGATGGTGTACCTGATGATGAGCTGGAT
TCAATCTTTAGGCCTTTCTACCGCGTTTCAACCGCTCGTGATCGTAACTCCGGCGGCACAGGGCTTGGCCTAACCATTAC
AGAGAGTGCGATTCGTCAACACAGCGGAACCATCACTGCAAGCCGTAGCCAGCTCGGTGGATTACAACTCAAAATCACCC
TGCCTATCCTGCCAGTGTAA

Upstream 100 bases:

>100_bases
ACATATCCAACCTGCGTAAAAAAATTCCAGAACGCAGTGACGGTAAATCTCGCATCAAAACCTTACGAGGCCGTGGTTAC
TTATTGGTAGAGGAAGATTA

Downstream 100 bases:

>100_bases
TACCCCTACAAAGATCACAGTTGATAATGATTTCCATTATCATTATGGTAAGTCCTCTAATTAAGGAGGATTTACCATGT
CACACTCTTTTCCTGCTCTA

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRIPKITSLYGRIFAIFWFTMLLVLLSVLSLPHLDPRVARDVPADHLDKLERIAKFTEKRYAKESNLGKIVFQLEAPRSR
KDSRARIYLTDLEGAVLTSKRHSNYKLKAIRNFVTSIDNPELPKQKLYGHYMVAGPVPITLAGEELLMYAGVKWNQPPPF
LLRLFDRPLQLLLAVMLASTPLLLWLAWALSQPARRLERAAQRVAKGQFEVDPTLEKGTSEFRQAGESFNQMVEAVNQMI
SGQQRLLSDISHELRSPLTRLRMANALAIRKQGESQELERIDMEAQRLEQMISELLTLSRMQVDSHITREVQPISSLWEE
ILKDAEFEAEQMGKLLTFSEIPDRSISGNPKLLMSALDNITRNAIYYGKDQVDVQFDVVQDRLTICVNDNGDGVPDDELD
SIFRPFYRVSTARDRNSGGTGLGLTITESAIRQHSGTITASRSQLGGLQLKITLPILPV

Sequences:

>Translated_459_residues
MRIPKITSLYGRIFAIFWFTMLLVLLSVLSLPHLDPRVARDVPADHLDKLERIAKFTEKRYAKESNLGKIVFQLEAPRSR
KDSRARIYLTDLEGAVLTSKRHSNYKLKAIRNFVTSIDNPELPKQKLYGHYMVAGPVPITLAGEELLMYAGVKWNQPPPF
LLRLFDRPLQLLLAVMLASTPLLLWLAWALSQPARRLERAAQRVAKGQFEVDPTLEKGTSEFRQAGESFNQMVEAVNQMI
SGQQRLLSDISHELRSPLTRLRMANALAIRKQGESQELERIDMEAQRLEQMISELLTLSRMQVDSHITREVQPISSLWEE
ILKDAEFEAEQMGKLLTFSEIPDRSISGNPKLLMSALDNITRNAIYYGKDQVDVQFDVVQDRLTICVNDNGDGVPDDELD
SIFRPFYRVSTARDRNSGGTGLGLTITESAIRQHSGTITASRSQLGGLQLKITLPILPV
>Mature_459_residues
MRIPKITSLYGRIFAIFWFTMLLVLLSVLSLPHLDPRVARDVPADHLDKLERIAKFTEKRYAKESNLGKIVFQLEAPRSR
KDSRARIYLTDLEGAVLTSKRHSNYKLKAIRNFVTSIDNPELPKQKLYGHYMVAGPVPITLAGEELLMYAGVKWNQPPPF
LLRLFDRPLQLLLAVMLASTPLLLWLAWALSQPARRLERAAQRVAKGQFEVDPTLEKGTSEFRQAGESFNQMVEAVNQMI
SGQQRLLSDISHELRSPLTRLRMANALAIRKQGESQELERIDMEAQRLEQMISELLTLSRMQVDSHITREVQPISSLWEE
ILKDAEFEAEQMGKLLTFSEIPDRSISGNPKLLMSALDNITRNAIYYGKDQVDVQFDVVQDRLTICVNDNGDGVPDDELD
SIFRPFYRVSTARDRNSGGTGLGLTITESAIRQHSGTITASRSQLGGLQLKITLPILPV

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=465, Percent_Identity=45.5913978494624, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=32.0512820512821, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1789808, Length=290, Percent_Identity=30.6896551724138, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786783, Length=273, Percent_Identity=29.3040293040293, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=29.136690647482, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=27.0547945205479, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=26.9565217391304, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=388, Percent_Identity=25, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=24.0418118466899, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.9592760180996, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=29.045643153527, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=25.1908396946565, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=27.5109170305677, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=27.7272727272727, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51948; Mature: 51948

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPKITSLYGRIFAIFWFTMLLVLLSVLSLPHLDPRVARDVPADHLDKLERIAKFTEKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
YAKESNLGKIVFQLEAPRSRKDSRARIYLTDLEGAVLTSKRHSNYKLKAIRNFVTSIDNP
HHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCHHEECCCCCCHHHHHHHHHHHCCCCC
ELPKQKLYGHYMVAGPVPITLAGEELLMYAGVKWNQPPPFLLRLFDRPLQLLLAVMLAST
CCCHHHHCCCEEEECCEEEEECCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PLLLWLAWALSQPARRLERAAQRVAKGQFEVDPTLEKGTSEFRQAGESFNQMVEAVNQMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGQQRLLSDISHELRSPLTRLRMANALAIRKQGESQELERIDMEAQRLEQMISELLTLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQVDSHITREVQPISSLWEEILKDAEFEAEQMGKLLTFSEIPDRSISGNPKLLMSALDNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHH
TRNAIYYGKDQVDVQFDVVQDRLTICVNDNGDGVPDDELDSIFRPFYRVSTARDRNSGGT
HHCCEEECCCCCCEEHEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GLGLTITESAIRQHSGTITASRSQLGGLQLKITLPILPV
CEEEEEEHHHHHHCCCCEEECHHHHCCEEEEEEECCCCC
>Mature Secondary Structure
MRIPKITSLYGRIFAIFWFTMLLVLLSVLSLPHLDPRVARDVPADHLDKLERIAKFTEKR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
YAKESNLGKIVFQLEAPRSRKDSRARIYLTDLEGAVLTSKRHSNYKLKAIRNFVTSIDNP
HHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCHHEECCCCCCHHHHHHHHHHHCCCCC
ELPKQKLYGHYMVAGPVPITLAGEELLMYAGVKWNQPPPFLLRLFDRPLQLLLAVMLAST
CCCHHHHCCCEEEECCEEEEECCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
PLLLWLAWALSQPARRLERAAQRVAKGQFEVDPTLEKGTSEFRQAGESFNQMVEAVNQMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGQQRLLSDISHELRSPLTRLRMANALAIRKQGESQELERIDMEAQRLEQMISELLTLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MQVDSHITREVQPISSLWEEILKDAEFEAEQMGKLLTFSEIPDRSISGNPKLLMSALDNI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHH
TRNAIYYGKDQVDVQFDVVQDRLTICVNDNGDGVPDDELDSIFRPFYRVSTARDRNSGGT
HHCCEEECCCCCCEEHEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GLGLTITESAIRQHSGTITASRSQLGGLQLKITLPILPV
CEEEEEEHHHHHHCCCCEEECHHHHCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]