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The map label for this gene is cpxR [H]

Identifier: 218710833

GI number: 218710833

Start: 3067502

End: 3068191

Strand: Direct

Name: cpxR [H]

Synonym: VS_2916

Alternate gene names: 218710833

Gene position: 3067502-3068191 (Clockwise)

Preceding gene: 218710829

Following gene: 218710834

Centisome position: 92.97

GC content: 45.51

Gene sequence:

>690_bases
ATGGCGAACATTCTTCTTATTGATGACGACACCGAGCTAACCGGCTTACTTAAAGACATACTGAGCTTTGAGGGATTCAC
TGTTTCCGAAGCCAATGACGGCTATGCGGGGTTGGAAGCTATCAATGATGAGATAGATTTGATTCTTTTGGACGTGATGA
TGCCGCGCCTTAACGGTATGGAAACACTAAAGAAACTAAGAGAAAATTGGGAAACGCCAGTACTGATGCTGACCGCAAAA
GGTGAAGAGATCGACCGTGTTATTGGCCTTGAGCTTGGCGCAGATGATTACTTGCCAAAGCCTTTCAGTGACCGAGAGCT
GCTCGCTCGTATTCGTGCCATCTTACGTAGAACGCAGATCAACACCGCTCCTAAAGCAGCCAGTGATAAGATTCAATATC
AAGACATTGAAGTATTTCCAGGTAAACAAGAAGCTTATTGTAATGGCCAGCTTATCGATCTTACCACCACCGAGTTCGCT
TTGCTGAGTCACCTAATCCAGAACCCAGGGCAAGTGATCACCAAGGAAGCGTTGAGTTTGGATGTTCTGGGTAAAAGGCT
TGCAGCATTTGACCGTGCGATAGACATGCACATATCCAACCTGCGTAAAAAAATTCCAGAACGCAGTGACGGTAAATCTC
GCATCAAAACCTTACGAGGCCGTGGTTACTTATTGGTAGAGGAAGATTAA

Upstream 100 bases:

>100_bases
GTAAAGCGACGTTTAGAAAGCGTAAAGAATCGTAAAGAGTGAAAGTTGACGAATAATTAGCAGTATTATTAACCTATAAA
CAACTGATTAAGGCTTCCCA

Downstream 100 bases:

>100_bases
TGCGTATCCCTAAAATCACCAGCTTATATGGACGTATCTTTGCTATCTTTTGGTTCACCATGTTACTGGTGCTTTTGTCG
GTACTGTCACTTCCCCATTT

Product: transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MANILLIDDDTELTGLLKDILSFEGFTVSEANDGYAGLEAINDEIDLILLDVMMPRLNGMETLKKLRENWETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQINTAPKAASDKIQYQDIEVFPGKQEAYCNGQLIDLTTTEFA
LLSHLIQNPGQVITKEALSLDVLGKRLAAFDRAIDMHISNLRKKIPERSDGKSRIKTLRGRGYLLVEED

Sequences:

>Translated_229_residues
MANILLIDDDTELTGLLKDILSFEGFTVSEANDGYAGLEAINDEIDLILLDVMMPRLNGMETLKKLRENWETPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQINTAPKAASDKIQYQDIEVFPGKQEAYCNGQLIDLTTTEFA
LLSHLIQNPGQVITKEALSLDVLGKRLAAFDRAIDMHISNLRKKIPERSDGKSRIKTLRGRGYLLVEED
>Mature_228_residues
ANILLIDDDTELTGLLKDILSFEGFTVSEANDGYAGLEAINDEIDLILLDVMMPRLNGMETLKKLRENWETPVLMLTAKG
EEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQINTAPKAASDKIQYQDIEVFPGKQEAYCNGQLIDLTTTEFAL
LSHLIQNPGQVITKEALSLDVLGKRLAAFDRAIDMHISNLRKKIPERSDGKSRIKTLRGRGYLLVEED

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=59.3886462882096, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=39.3013100436681, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.7777777777778, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=37.1681415929204, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=36, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=37.0535714285714, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=35.6828193832599, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.5309734513274, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=35.2422907488987, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=34.6491228070175, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=31.140350877193, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.6964285714286, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.9012875536481, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790437, Length=144, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=35.8490566037736, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=29.8387096774194, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25727; Mature: 25596

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANILLIDDDTELTGLLKDILSFEGFTVSEANDGYAGLEAINDEIDLILLDVMMPRLNGM
CCEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCH
ETLKKLRENWETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQI
HHHHHHHHCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
NTAPKAASDKIQYQDIEVFPGKQEAYCNGQLIDLTTTEFALLSHLIQNPGQVITKEALSL
CCCCCCCCCCEEEEEEEECCCCCCCEECCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHH
DVLGKRLAAFDRAIDMHISNLRKKIPERSDGKSRIKTLRGRGYLLVEED
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
ANILLIDDDTELTGLLKDILSFEGFTVSEANDGYAGLEAINDEIDLILLDVMMPRLNGM
CEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCH
ETLKKLRENWETPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIRAILRRTQI
HHHHHHHHCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
NTAPKAASDKIQYQDIEVFPGKQEAYCNGQLIDLTTTEFALLSHLIQNPGQVITKEALSL
CCCCCCCCCCEEEEEEEECCCCCCCEECCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHH
DVLGKRLAAFDRAIDMHISNLRKKIPERSDGKSRIKTLRGRGYLLVEED
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]