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The map label for this gene is menA [H]

Identifier: 218710820

GI number: 218710820

Start: 3057862

End: 3058779

Strand: Direct

Name: menA [H]

Synonym: VS_2903

Alternate gene names: 218710820

Gene position: 3057862-3058779 (Clockwise)

Preceding gene: 218710819

Following gene: 218710821

Centisome position: 92.68

GC content: 46.62

Gene sequence:

>918_bases
ATGAAACAATCTCTACTGATTTGGCTTGATGCCGCACGCCCAAAAACTCTGCCTCTCGCACTTGTCTCTATTCTTACAGG
AAGTAGTTTAGCGTTCGCTGGTGGTCATTTTTCTTTATCAATAGCCCTGCTGGCATTTTTAACCGCCACTCTATTACAGA
TTCTGTCGAACTTAGCCAATGACTATGGCGACGCGGTAAAAGGCACAGACAACGAAAACCGTCTAGGGCCAACACGTGCA
ATGCAATCTGGCGCGGTGACCGCGAAAACCATGAAGCAAGCGATCATCCTCAACATCGTATTTACCATGCTCGCTGGGCT
GATTCTTATCTTTCATGCCTTAACCTCGATTGAGAGTATCTTATCTTTCATTGCGTTAGGCGTATTAGCCATTGTTGCAG
CCATCGCTTACACCGTCGGCAATAAACCTTATGGTTATATTGGCCTTGGCGACTTATCGGTATTTATCTTCTTCGGTTTG
TTAGGCGTTTCAGGGACTTATTTCTTACACACTGGCCATGTTGAACCAAGCCTATTCCTTCCGGCATTGGGCTGCGGCTT
GATGGCGGTTGCGGTACTCAATATCAACAACATGCGGGATATTGAAAACGACAGCGAATGTGGCAAACGCACCATGGCGG
TTCGCCTAGGGCAGCGCAAAGCCAAACACTATCATTTTGCACTGCTTGGGCTCGCCCTTGCCTCTTTCGCTATCTACCTA
CTGATTCAAGAAAAACCGGTCTGGATCAGCCTGCCGTTTTTACTAAGCATTATTATTGTTTATAAGCACGGTAAGGCCGT
TTGGGAAACCGAAAAGCCAGCGCAGATTGCACCAATGATGCCCGTGATAGTGAAATGTTCACTGGTCACTAACCTATTGT
TTGCAGGGGTTGTCGTAGCTCAAACTCTATTGAGTTAA

Upstream 100 bases:

>100_bases
ATTCAAGGCCCACTTTCGAGTGGGCTTTTTATTACCCGAAAAATGGGCGTATACTCAAATCACAGTATGAAACGAAGACT
TACAAAGAATTAGACCTACG

Downstream 100 bases:

>100_bases
ATGAGACTAATCATTGCAAAGGGATCAAGCACCGATATACTCAAAGTAAGCTCATTGTTCAAAAGGTATACTAATGGAAT
ACAACACTTCAGCACTGTGC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKQSLLIWLDAARPKTLPLALVSILTGSSLAFAGGHFSLSIALLAFLTATLLQILSNLANDYGDAVKGTDNENRLGPTRA
MQSGAVTAKTMKQAIILNIVFTMLAGLILIFHALTSIESILSFIALGVLAIVAAIAYTVGNKPYGYIGLGDLSVFIFFGL
LGVSGTYFLHTGHVEPSLFLPALGCGLMAVAVLNINNMRDIENDSECGKRTMAVRLGQRKAKHYHFALLGLALASFAIYL
LIQEKPVWISLPFLLSIIIVYKHGKAVWETEKPAQIAPMMPVIVKCSLVTNLLFAGVVVAQTLLS

Sequences:

>Translated_305_residues
MKQSLLIWLDAARPKTLPLALVSILTGSSLAFAGGHFSLSIALLAFLTATLLQILSNLANDYGDAVKGTDNENRLGPTRA
MQSGAVTAKTMKQAIILNIVFTMLAGLILIFHALTSIESILSFIALGVLAIVAAIAYTVGNKPYGYIGLGDLSVFIFFGL
LGVSGTYFLHTGHVEPSLFLPALGCGLMAVAVLNINNMRDIENDSECGKRTMAVRLGQRKAKHYHFALLGLALASFAIYL
LIQEKPVWISLPFLLSIIIVYKHGKAVWETEKPAQIAPMMPVIVKCSLVTNLLFAGVVVAQTLLS
>Mature_305_residues
MKQSLLIWLDAARPKTLPLALVSILTGSSLAFAGGHFSLSIALLAFLTATLLQILSNLANDYGDAVKGTDNENRLGPTRA
MQSGAVTAKTMKQAIILNIVFTMLAGLILIFHALTSIESILSFIALGVLAIVAAIAYTVGNKPYGYIGLGDLSVFIFFGL
LGVSGTYFLHTGHVEPSLFLPALGCGLMAVAVLNINNMRDIENDSECGKRTMAVRLGQRKAKHYHFALLGLALASFAIYL
LIQEKPVWISLPFLLSIIIVYKHGKAVWETEKPAQIAPMMPVIVKCSLVTNLLFAGVVVAQTLLS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=295, Percent_Identity=49.8305084745763, Blast_Score=286, Evalue=9e-79,
Organism=Drosophila melanogaster, GI17737429, Length=297, Percent_Identity=27.6094276094276, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32713; Mature: 32713

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSLLIWLDAARPKTLPLALVSILTGSSLAFAGGHFSLSIALLAFLTATLLQILSNLAN
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DYGDAVKGTDNENRLGPTRAMQSGAVTAKTMKQAIILNIVFTMLAGLILIFHALTSIESI
HHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFIALGVLAIVAAIAYTVGNKPYGYIGLGDLSVFIFFGLLGVSGTYFLHTGHVEPSLFL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
PALGCGLMAVAVLNINNMRDIENDSECGKRTMAVRLGQRKAKHYHFALLGLALASFAIYL
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQEKPVWISLPFLLSIIIVYKHGKAVWETEKPAQIAPMMPVIVKCSLVTNLLFAGVVVA
HEECCCCEEEHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHH
QTLLS
HHHCC
>Mature Secondary Structure
MKQSLLIWLDAARPKTLPLALVSILTGSSLAFAGGHFSLSIALLAFLTATLLQILSNLAN
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DYGDAVKGTDNENRLGPTRAMQSGAVTAKTMKQAIILNIVFTMLAGLILIFHALTSIESI
HHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSFIALGVLAIVAAIAYTVGNKPYGYIGLGDLSVFIFFGLLGVSGTYFLHTGHVEPSLFL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
PALGCGLMAVAVLNINNMRDIENDSECGKRTMAVRLGQRKAKHYHFALLGLALASFAIYL
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIQEKPVWISLPFLLSIIIVYKHGKAVWETEKPAQIAPMMPVIVKCSLVTNLLFAGVVVA
HEECCCCEEEHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHH
QTLLS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]