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The map label for this gene is argG [H]

Identifier: 218710803

GI number: 218710803

Start: 3035333

End: 3036601

Strand: Reverse

Name: argG [H]

Synonym: VS_2886

Alternate gene names: 218710803

Gene position: 3036601-3035333 (Counterclockwise)

Preceding gene: 218710804

Following gene: 218710802

Centisome position: 92.04

GC content: 46.26

Gene sequence:

>1269_bases
ATGAAGTCATTTCCAACGCTGACCGCCATGTGCAGTATGGAAACTAGGAGAAAGAAAATGAGCAAAGTTAACGTAAAGAA
AGTTGTAGTAGCCTACTCTGGCGGTCTAGACACATCAGTAATTATTCCATGGTTGAAAGAGAACTATGATTGCGAAGTTA
TCGCATTTGTTGCAGATGTAGGCCAAGGCGATGAAGAGCTGATTGGTATTGAAGAGAAAGCAAAAGCTTCTGGTGCATCT
GAGTGTTACATCGCTGACCTTAAAGAAGAGATGGTGGCAGATTACATCTACCCAACGCTAAAAACTGGCGCTTACTACGA
AGGTAAATACCTACTAGGTACTTCAATGGCTCGTCCAATTATCGCGAAAGCTCAGGTTGAGGTTGCACGTAAAGTCGGTG
CAGACGCACTGTGTCACGGCTGTACAGGTAAGGGGAACGACCAAGTTCGTTTTGAAGGCGCATTTGCTGCCCTCGCACCA
GACTTACACGTAATTGCACCATGGCGTGAATGGGATCTAGTGAGCCGTGAAGAGTGTCTAGATTACTTAGCTGAACGTAA
CATCCCTTGTACGGCTTCTCTTACTAAGATCTACTCGCGTGATGCAAACGCATGGCATATATCTACAGAGGGCGGCGTGC
TAGAAAATACATGGAACGCACCGGATGAAGATTGCTGGGCTTGGACTGTAGACCCAGAGCAAGCGCCAAACGAATCTGAA
ACTGTGACGCTTAAAGTTGAAAAAGGTGAAGTGGTAGCGGTTGATGGCGAAACAATGACGCCATACAACGCACTGGTTTA
CCTAAATGAGAAGGGTGCGAAGCACGGTGTTGGTCGTATCGATATCGTAGAGAACCGTCTTGTTGGCATGAAGTCTCGTG
GTTGTTACGAAACTCCAGGTGGCACAATCATGATGGAAGCACTGCGTGCAGTAGAGCAACTGGTTCTTGATAAAGCGGCA
TTCGAATTCCGTGAAGAGCTAGGTGTTAAAGCTTCTCACCTTGTATACGACGGTCGTTGGTTCACTCCGCTATGTAAGTC
AATTCTTGCGGCAACAGATGAACTAGCACAAGACGTAAATGGTGAAGTGGTTATTAAGCTTTACAAAGGCCATGCAACTG
TGACTCAGAAGCGTTCTGACAACAGCCTGTACTCAGAAGAGTTTGCAACCTTTGGTGAAGATGAAGTTTACGACCAAAGC
CACGCTGAAGGCTTCATCCGTCTTTACTCGTTATCAAGCCGTATCCGTGCTCTGAATAGCCAAAAGTAA

Upstream 100 bases:

>100_bases
TGTTTTCAGGTAAAAGCATAGGAACGCAGTTTTTACCTCAGTAGACCTCACCACGAGTCACTACTTAAAGAATTTAGACA
AATAAATTTAACACATAATA

Downstream 100 bases:

>100_bases
TCCGAACCATGAGTTAGTGAGCTAGCCTTTTACGAATAACGGAAGGCTAGTAAATAGACATTATTATGCAAAGCCCATCC
ACTATTGATTAGTGAATGGG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKSFPTLTAMCSMETRRKKMSKVNVKKVVVAYSGGLDTSVIIPWLKENYDCEVIAFVADVGQGDEELIGIEEKAKASGAS
ECYIADLKEEMVADYIYPTLKTGAYYEGKYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGAFAALAP
DLHVIAPWREWDLVSREECLDYLAERNIPCTASLTKIYSRDANAWHISTEGGVLENTWNAPDEDCWAWTVDPEQAPNESE
TVTLKVEKGEVVAVDGETMTPYNALVYLNEKGAKHGVGRIDIVENRLVGMKSRGCYETPGGTIMMEALRAVEQLVLDKAA
FEFREELGVKASHLVYDGRWFTPLCKSILAATDELAQDVNGEVVIKLYKGHATVTQKRSDNSLYSEEFATFGEDEVYDQS
HAEGFIRLYSLSSRIRALNSQK

Sequences:

>Translated_422_residues
MKSFPTLTAMCSMETRRKKMSKVNVKKVVVAYSGGLDTSVIIPWLKENYDCEVIAFVADVGQGDEELIGIEEKAKASGAS
ECYIADLKEEMVADYIYPTLKTGAYYEGKYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGAFAALAP
DLHVIAPWREWDLVSREECLDYLAERNIPCTASLTKIYSRDANAWHISTEGGVLENTWNAPDEDCWAWTVDPEQAPNESE
TVTLKVEKGEVVAVDGETMTPYNALVYLNEKGAKHGVGRIDIVENRLVGMKSRGCYETPGGTIMMEALRAVEQLVLDKAA
FEFREELGVKASHLVYDGRWFTPLCKSILAATDELAQDVNGEVVIKLYKGHATVTQKRSDNSLYSEEFATFGEDEVYDQS
HAEGFIRLYSLSSRIRALNSQK
>Mature_422_residues
MKSFPTLTAMCSMETRRKKMSKVNVKKVVVAYSGGLDTSVIIPWLKENYDCEVIAFVADVGQGDEELIGIEEKAKASGAS
ECYIADLKEEMVADYIYPTLKTGAYYEGKYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGAFAALAP
DLHVIAPWREWDLVSREECLDYLAERNIPCTASLTKIYSRDANAWHISTEGGVLENTWNAPDEDCWAWTVDPEQAPNESE
TVTLKVEKGEVVAVDGETMTPYNALVYLNEKGAKHGVGRIDIVENRLVGMKSRGCYETPGGTIMMEALRAVEQLVLDKAA
FEFREELGVKASHLVYDGRWFTPLCKSILAATDELAQDVNGEVVIKLYKGHATVTQKRSDNSLYSEEFATFGEDEVYDQS
HAEGFIRLYSLSSRIRALNSQK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=394, Percent_Identity=42.6395939086294, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI16950633, Length=394, Percent_Identity=42.6395939086294, Blast_Score=299, Evalue=3e-81,
Organism=Escherichia coli, GI1789563, Length=386, Percent_Identity=27.4611398963731, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324514, Length=411, Percent_Identity=38.4428223844282, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21358151, Length=408, Percent_Identity=39.4607843137255, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 46753; Mature: 46753

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFPTLTAMCSMETRRKKMSKVNVKKVVVAYSGGLDTSVIIPWLKENYDCEVIAFVADV
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEEHHCCCCCCEEEEEEECC
GQGDEELIGIEEKAKASGASECYIADLKEEMVADYIYPTLKTGAYYEGKYLLGTSMARPI
CCCHHHEECCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEECCEEEECCCCCCCH
IAKAQVEVARKVGADALCHGCTGKGNDQVRFEGAFAALAPDLHVIAPWREWDLVSREECL
HHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCHHHHCCCCEEECCCHHCCCCCHHHHH
DYLAERNIPCTASLTKIYSRDANAWHISTEGGVLENTWNAPDEDCWAWTVDPEQAPNESE
HHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCEEEEECHHCCCCCCC
TVTLKVEKGEVVAVDGETMTPYNALVYLNEKGAKHGVGRIDIVENRLVGMKSRGCYETPG
EEEEEEECCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
GTIMMEALRAVEQLVLDKAAFEFREELGVKASHLVYDGRWFTPLCKSILAATDELAQDVN
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCEEHHHHHHHHHHHHHHHHHCCC
GEVVIKLYKGHATVTQKRSDNSLYSEEFATFGEDEVYDQSHAEGFIRLYSLSSRIRALNS
CEEEEEEEECCEEEEECCCCCCHHHHHHHCCCCCHHCCCHHHHHEEEEEHHHHHHHHHCC
QK
CC
>Mature Secondary Structure
MKSFPTLTAMCSMETRRKKMSKVNVKKVVVAYSGGLDTSVIIPWLKENYDCEVIAFVADV
CCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEEHHCCCCCCEEEEEEECC
GQGDEELIGIEEKAKASGASECYIADLKEEMVADYIYPTLKTGAYYEGKYLLGTSMARPI
CCCHHHEECCHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEECCEEEECCCCCCCH
IAKAQVEVARKVGADALCHGCTGKGNDQVRFEGAFAALAPDLHVIAPWREWDLVSREECL
HHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEECCHHHHCCCCEEECCCHHCCCCCHHHHH
DYLAERNIPCTASLTKIYSRDANAWHISTEGGVLENTWNAPDEDCWAWTVDPEQAPNESE
HHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCEEEEECHHCCCCCCC
TVTLKVEKGEVVAVDGETMTPYNALVYLNEKGAKHGVGRIDIVENRLVGMKSRGCYETPG
EEEEEEECCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
GTIMMEALRAVEQLVLDKAAFEFREELGVKASHLVYDGRWFTPLCKSILAATDELAQDVN
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCEEHHHHHHHHHHHHHHHHHCCC
GEVVIKLYKGHATVTQKRSDNSLYSEEFATFGEDEVYDQSHAEGFIRLYSLSSRIRALNS
CEEEEEEEECCEEEEECCCCCCHHHHHHHCCCCCHHCCCHHHHHEEEEEHHHHHHHHHCC
QK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA