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The map label for this gene is argH [H]

Identifier: 218710802

GI number: 218710802

Start: 3033111

End: 3034985

Strand: Reverse

Name: argH [H]

Synonym: VS_2885

Alternate gene names: 218710802

Gene position: 3034985-3033111 (Counterclockwise)

Preceding gene: 218710803

Following gene: 218710800

Centisome position: 91.99

GC content: 46.99

Gene sequence:

>1875_bases
ATGGCATTATGGGGCGGTAGATTTACCCAAGCAGCAGACACCCGGTTTAAAGATTTTAACGATTCTCTTCGTTTTGATTA
CCGATTGGCTGAGCAAGACATTGTGGGCTCAATTGCCTGGTCTAAAGCTCTACTGTCGGTCAACGTATTAACCGAAGAAG
AGCAACAGAAGCTTGAGTTAGCGTTGAATGAGCTAAAACTTGAGGTGATGGAAGATCCTGAACAGATTCTACGTTCTGAT
GCAGAAGATATTCACAGCTGGGTCGAGCAACAACTTATCGGCAAAGTCGGTGACTTGGGCAAAAAACTTCACACTGGCCG
TTCTCGTAATGACCAAGTGGCGACCGACCTGAAATTATGGTGTCGTCAGCAAGGTAATCAACTGCTACTGGCATTGGATC
GCCTACAAAGCCAAATGGTGAACGTTGCTTCTCAGCATCAAGAAACCGTGCTTCCTGGCTACACTCACTTACAACGTGCT
CAGCCGGTAACTTTTGCTCACTGGTGCTTGGCTTACGTTGAAATGCTTGAGCGTGATTATTCTCGTTTGAATGATGCGAT
TAAGCGTCTAGATACATGTCCGCTGGGTTCTGGTGCCCTTGCAGGAACTGCTTACCCGATGGACCGTGAAGAGTTAGCTC
ACAACTTAGGTTTCCGTCGTGCAACGCGCAACTCTCTAGATTCAGTTTCTGACCGTGATCATGTGATGGAGCTGATGTCG
ATCGCTTCTATTTCAATGCTTCACCTTTCACGTCTTGCAGAAGATATGATTTTCTACAACTCAGGTGAATCGAACTTCAT
CGAGTTAGCGGATACCGTGACGTCAGGTTCATCTCTGATGCCACAAAAGAAAAACCCTGATGCGCTCGAACTTATCCGTG
GCAAAACTGGCCGTGTGTACGGTTCATTAGCCGCAATGATGATGACAGTGAAAGCCCTGCCTTTGGCGTACAACAAAGAT
ATGCAAGAAGATAAAGAAGGTCTGTTCGACGCTTTAGACACTTGGAATGATTGTATGGAAATGGCTGCTCTTTGTTTTGA
CGGCATTAAAGTGAATGGCGAACGTACACTTGAAGCAGCGAAACAAGGCTACGCGAACTCAACCGAACTGGCTGATTACC
TAGTAGCGAAAGGCATTCCTTTCCGTGAAGCTCACCATATTGTTGGTGTGACGGTAGTGGCGGCGATTGCTAAAGGTTGT
GCATTAGAAGAGTTAACCATCGCAGAGATGAAAGAGTTCTCTGAGGTGATTGAAGAGGATGTGTATGACATCCTGACTAT
TGAATCGTGTCTTGAAAAACGTAGCGCGCTAGGCGGTGTATCACCACAGCAAGTGGCTTACGCGGTTGACCAAGCTGAGA
AGCGTTTATCACAGCGTGATACTTCTATCGTTAAGGTTCGTTCTGCTCGTCTGACCGATATTGAAGCGTTGGAAGGCATG
GTGGCCTACTGGGCTAATATGGGTGAAAACCTGCCTCGTTCTCGTAATGAACTGGTGCGTGATATTGGCTCGTTTGCCGT
CGCAGAGCATCATGGAGAGGTGACGGGTTGTGCATCACTCTATGTGTATGACTCTGGTTTAGCGGAAATCCGTTCGTTAG
GTGTTGAAGCTGGCTGGCAAGGTCAAGGGCAGGGCACCGCGATTGTGCAGCACTTGGTTGATAAAGCGCGACAAATGGCG
ATCAAGAAGGTGTTTGTGCTGACTCGTACCCCAGAGTTCTTTATGAAGCATGACTTTTTACCGACATCAAAATCTCTGTT
GCCTGAGAAGGTACTGAAAGATTGTGATCAGTGTCCTCGCCAACATGCATGTGATGAAGTGGCGTTGGAAGTGAACTTGG
TTGAACAGATCATCGCAAAGGTAAATGTTGCATAA

Upstream 100 bases:

>100_bases
TTTGAATTGCCGTAAGTTTAAACCATCAGAAAAATACTGAATTTTAATCAGAATTATCATTTGCAAAAACAGTGAGCACT
GTGCAATTAGGAGATACACA

Downstream 100 bases:

>100_bases
GGCATTGATTTTATGGCGCCTAAAAAAAAGATCAAAAATCTGATCTTTTTTGGGAACAAACTGAGAAAAGTCCGGTCTAT
TAAAGTACCACTGCTTTTTC

Product: bifunctional argininosuccinate lyase/N-acetylglutamate synthase

Products: NA

Alternate protein names: Argininosuccinate lyase; ASAL; Arginosuccinase; Probable acetyltransferase [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MALWGGRFTQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLTEEEQQKLELALNELKLEVMEDPEQILRSD
AEDIHSWVEQQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGNQLLLALDRLQSQMVNVASQHQETVLPGYTHLQRA
QPVTFAHWCLAYVEMLERDYSRLNDAIKRLDTCPLGSGALAGTAYPMDREELAHNLGFRRATRNSLDSVSDRDHVMELMS
IASISMLHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVYGSLAAMMMTVKALPLAYNKD
MQEDKEGLFDALDTWNDCMEMAALCFDGIKVNGERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVTVVAAIAKGC
ALEELTIAEMKEFSEVIEEDVYDILTIESCLEKRSALGGVSPQQVAYAVDQAEKRLSQRDTSIVKVRSARLTDIEALEGM
VAYWANMGENLPRSRNELVRDIGSFAVAEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQGQGQGTAIVQHLVDKARQMA
IKKVFVLTRTPEFFMKHDFLPTSKSLLPEKVLKDCDQCPRQHACDEVALEVNLVEQIIAKVNVA

Sequences:

>Translated_624_residues
MALWGGRFTQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLTEEEQQKLELALNELKLEVMEDPEQILRSD
AEDIHSWVEQQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGNQLLLALDRLQSQMVNVASQHQETVLPGYTHLQRA
QPVTFAHWCLAYVEMLERDYSRLNDAIKRLDTCPLGSGALAGTAYPMDREELAHNLGFRRATRNSLDSVSDRDHVMELMS
IASISMLHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVYGSLAAMMMTVKALPLAYNKD
MQEDKEGLFDALDTWNDCMEMAALCFDGIKVNGERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVTVVAAIAKGC
ALEELTIAEMKEFSEVIEEDVYDILTIESCLEKRSALGGVSPQQVAYAVDQAEKRLSQRDTSIVKVRSARLTDIEALEGM
VAYWANMGENLPRSRNELVRDIGSFAVAEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQGQGQGTAIVQHLVDKARQMA
IKKVFVLTRTPEFFMKHDFLPTSKSLLPEKVLKDCDQCPRQHACDEVALEVNLVEQIIAKVNVA
>Mature_623_residues
ALWGGRFTQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLTEEEQQKLELALNELKLEVMEDPEQILRSDA
EDIHSWVEQQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGNQLLLALDRLQSQMVNVASQHQETVLPGYTHLQRAQ
PVTFAHWCLAYVEMLERDYSRLNDAIKRLDTCPLGSGALAGTAYPMDREELAHNLGFRRATRNSLDSVSDRDHVMELMSI
ASISMLHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVYGSLAAMMMTVKALPLAYNKDM
QEDKEGLFDALDTWNDCMEMAALCFDGIKVNGERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVTVVAAIAKGCA
LEELTIAEMKEFSEVIEEDVYDILTIESCLEKRSALGGVSPQQVAYAVDQAEKRLSQRDTSIVKVRSARLTDIEALEGMV
AYWANMGENLPRSRNELVRDIGSFAVAEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQGQGQGTAIVQHLVDKARQMAI
KKVFVLTRTPEFFMKHDFLPTSKSLLPEKVLKDCDQCPRQHACDEVALEVNLVEQIIAKVNVA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=42.9515418502203, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=42.9515418502203, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=40.7488986784141, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=40.7572383073497, Blast_Score=325, Evalue=1e-88,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=73.2456140350877, Blast_Score=690, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=43.1372549019608, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=41.3092550790068, Blast_Score=345, Evalue=7e-95,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=41.3092550790068, Blast_Score=345, Evalue=7e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR009049
- InterPro:   IPR011244
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 69553; Mature: 69422

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFTQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLTEEEQQKLEL
CCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALNELKLEVMEDPEQILRSDAEDIHSWVEQQLIGKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRQQGNQLLLALDRLQSQMVNVASQHQETVLPGYTHLQRAQPVTFAHWCLAYVEMLERDY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLNDAIKRLDTCPLGSGALAGTAYPMDREELAHNLGFRRATRNSLDSVSDRDHVMELMS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHH
IASISMLHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLAAMMMTVKALPLAYNKDMQEDKEGLFDALDTWNDCMEMAALCFDGIKVNGERTLEAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHH
KQGYANSTELADYLVAKGIPFREAHHIVGVTVVAAIAKGCALEELTIAEMKEFSEVIEED
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VYDILTIESCLEKRSALGGVSPQQVAYAVDQAEKRLSQRDTSIVKVRSARLTDIEALEGM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHH
VAYWANMGENLPRSRNELVRDIGSFAVAEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHCCCCCCCC
GQGQGTAIVQHLVDKARQMAIKKVFVLTRTPEFFMKHDFLPTSKSLLPEKVLKDCDQCPR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHCHHHHHHHHHHCHH
QHACDEVALEVNLVEQIIAKVNVA
HHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALWGGRFTQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLTEEEQQKLEL
CCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALNELKLEVMEDPEQILRSDAEDIHSWVEQQLIGKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRQQGNQLLLALDRLQSQMVNVASQHQETVLPGYTHLQRAQPVTFAHWCLAYVEMLERDY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLNDAIKRLDTCPLGSGALAGTAYPMDREELAHNLGFRRATRNSLDSVSDRDHVMELMS
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHH
IASISMLHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVY
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GSLAAMMMTVKALPLAYNKDMQEDKEGLFDALDTWNDCMEMAALCFDGIKVNGERTLEAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHH
KQGYANSTELADYLVAKGIPFREAHHIVGVTVVAAIAKGCALEELTIAEMKEFSEVIEED
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VYDILTIESCLEKRSALGGVSPQQVAYAVDQAEKRLSQRDTSIVKVRSARLTDIEALEGM
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHH
VAYWANMGENLPRSRNELVRDIGSFAVAEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHCCCCCCCC
GQGQGTAIVQHLVDKARQMAIKKVFVLTRTPEFFMKHDFLPTSKSLLPEKVLKDCDQCPR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHCHHHHHHHHHHCHH
QHACDEVALEVNLVEQIIAKVNVA
HHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]