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The map label for this gene is proC [H]

Identifier: 218710630

GI number: 218710630

Start: 2872186

End: 2873004

Strand: Direct

Name: proC [H]

Synonym: VS_2684

Alternate gene names: 218710630

Gene position: 2872186-2873004 (Clockwise)

Preceding gene: 218710629

Following gene: 218710631

Centisome position: 87.05

GC content: 47.5

Gene sequence:

>819_bases
ATGGAACATAAGAACATCGCCTTTATTGGGGCGGGAAACATGGTTCGCTCAATTGTAGCGGGCTTAGTCGCGAGTGGTTA
CCCAGCGCAAAAGATTACTGCTACAGCACCTTCAGACACCAGAAGGCTGCCGCTAGAGCAAGAGTACAGTATCAATACCA
CCAGCGATAATATTGCAGCAGCAGAGCAAGCAGACGTTGTGGTGTTATCCGTGAAACCACAAATGATGGCTGATGTATGT
AAACCCTTACAAGATATCGACTTCAGCAACAAACTGGTTATCTCAATTGCCGCGGGTATTAATGCGAATCGACTCAATGA
GATGTTAAACTGCCAACTGAACCTTGTTCGTGTGATGCCAAACACGCCATCGCTGCTTGGTAAAGGGATGAGCGGTCTTT
ATGCTGATTCAACGGTCAGCCAAAATGATAAAGACTTTGCTTCTCAGCTGATGCAAGCTGTAGGTGAAGTTAGCTGGGTT
GAGCAAGAATCTGGGATTAATAACATCATTGCGGCGGCGGGCAGTGCTCCGGCTTACTTCTTCCTATTTATGGAAGCGAT
GCAAGCCGAAGCAATCAACCAAGGCTTCGACCAGGAAACCGCTCGTAAATTAGTGCAGCAGTCGGCATTAGGTGCGGCAG
AGATGGTGGTTGCAAATCCAGACACAGAATTATCTACACTGCGTGAACAAGTGACTTCAAAAGGCGGCACAACCGCAGAA
GCACTGCGCACGTTTAACGACCATCAACTTTCAGATATCGTAGCAAAAGCCATGCAAGCGGCGGTTGCTCGAGCTGAAGA
GATGGAAAAACTGTTTTAA

Upstream 100 bases:

>100_bases
TGGTGCTCGTGATTACGCGAATAACCGTAGTAAGTAACCAAGTACAAGTATTGATACCGCTTCGCTTGAACCGCGCAGCG
ACACGCTCAGGATTTTATAT

Downstream 100 bases:

>100_bases
TACTAATTACAGTAAAAAGCATTTTGTCGCTCGGGTTATATCTAAGCGGCAAGTAAATCCGAAAAAGGAAACAATATGAA
CTCGATGAGCTTTCTGATCT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEHKNIAFIGAGNMVRSIVAGLVASGYPAQKITATAPSDTRRLPLEQEYSINTTSDNIAAAEQADVVVLSVKPQMMADVC
KPLQDIDFSNKLVISIAAGINANRLNEMLNCQLNLVRVMPNTPSLLGKGMSGLYADSTVSQNDKDFASQLMQAVGEVSWV
EQESGINNIIAAAGSAPAYFFLFMEAMQAEAINQGFDQETARKLVQQSALGAAEMVVANPDTELSTLREQVTSKGGTTAE
ALRTFNDHQLSDIVAKAMQAAVARAEEMEKLF

Sequences:

>Translated_272_residues
MEHKNIAFIGAGNMVRSIVAGLVASGYPAQKITATAPSDTRRLPLEQEYSINTTSDNIAAAEQADVVVLSVKPQMMADVC
KPLQDIDFSNKLVISIAAGINANRLNEMLNCQLNLVRVMPNTPSLLGKGMSGLYADSTVSQNDKDFASQLMQAVGEVSWV
EQESGINNIIAAAGSAPAYFFLFMEAMQAEAINQGFDQETARKLVQQSALGAAEMVVANPDTELSTLREQVTSKGGTTAE
ALRTFNDHQLSDIVAKAMQAAVARAEEMEKLF
>Mature_272_residues
MEHKNIAFIGAGNMVRSIVAGLVASGYPAQKITATAPSDTRRLPLEQEYSINTTSDNIAAAEQADVVVLSVKPQMMADVC
KPLQDIDFSNKLVISIAAGINANRLNEMLNCQLNLVRVMPNTPSLLGKGMSGLYADSTVSQNDKDFASQLMQAVGEVSWV
EQESGINNIIAAAGSAPAYFFLFMEAMQAEAINQGFDQETARKLVQQSALGAAEMVVANPDTELSTLREQVTSKGGTTAE
ALRTFNDHQLSDIVAKAMQAAVARAEEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=27.6119402985075, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=27.7372262773723, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=27.7372262773723, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=27.6363636363636, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=33.0855018587361, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=31.0606060606061, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=25.6944444444444, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=32.9588014981273, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=28.5198555956679, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=32.3529411764706, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29177; Mature: 29177

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKNIAFIGAGNMVRSIVAGLVASGYPAQKITATAPSDTRRLPLEQEYSINTTSDNIAA
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHH
AEQADVVVLSVKPQMMADVCKPLQDIDFSNKLVISIAAGINANRLNEMLNCQLNLVRVMP
CCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEEECC
NTPSLLGKGMSGLYADSTVSQNDKDFASQLMQAVGEVSWVEQESGINNIIAAAGSAPAYF
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHH
FLFMEAMQAEAINQGFDQETARKLVQQSALGAAEMVVANPDTELSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHCCCCHHH
ALRTFNDHQLSDIVAKAMQAAVARAEEMEKLF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHKNIAFIGAGNMVRSIVAGLVASGYPAQKITATAPSDTRRLPLEQEYSINTTSDNIAA
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHH
AEQADVVVLSVKPQMMADVCKPLQDIDFSNKLVISIAAGINANRLNEMLNCQLNLVRVMP
CCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEEECC
NTPSLLGKGMSGLYADSTVSQNDKDFASQLMQAVGEVSWVEQESGINNIIAAAGSAPAYF
CCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHH
FLFMEAMQAEAINQGFDQETARKLVQQSALGAAEMVVANPDTELSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHCCCCHHH
ALRTFNDHQLSDIVAKAMQAAVARAEEMEKLF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]