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The map label for this gene is oadA [H]

Identifier: 218710530

GI number: 218710530

Start: 2760460

End: 2762250

Strand: Reverse

Name: oadA [H]

Synonym: VS_2569

Alternate gene names: 218710530

Gene position: 2762250-2760460 (Counterclockwise)

Preceding gene: 218710531

Following gene: 218710529

Centisome position: 83.72

GC content: 48.07

Gene sequence:

>1791_bases
ATGAGCATGTCTAAACCACTAGCTATCACAGATGTGGTACTTCGTGACGCGCACCAGTCACTATTTGCTACTCGTATGCG
TATCGAAGATATGCTGCCAATTGCGGCAGAACTGGATAAAGTCGGTTACTGGTCACTTGAGACTTGGGGCGGCGCAACGT
TTGATTCGTGCATCCGTTTTCTTGGAGAAGATCCGTGGGAACGTTTACGAGAGCTGAAAAAAGCGATGCCCAACACACCA
ATGCAGATGCTACTGCGTGGTCAAAATTTATTGGGTTACCGTCACTACGCGGATGATGTAGTAGAAAAGTTTGTTGAACG
TGCCCATAGTAACGGCATGGACGTATTCCGTATTTTTGATGCGATGAATGACGTACGTAACTTTGAAACCGCAGTGAAAG
CAACGATTGATGTTGGCGGCCACGCTCAAGGTACGTTGTCTTACACAACCAGTCCGGTTCACAACTCAGATACGTGGGTT
GATTTGGCTAAGCGCCTAGAGGATCTAGGTTGTCATTCACTATGCATCAAAGACATGTCAGGTTTATTAAAGCCTTATGA
AGCGGAAGAGCTAATCACTCGCATCAAAGCGTCTTGTGATGTGCCTCTAGCGCTGCATAGCCACGCGACAACGGGTCTAT
CAACCGCTACAGCCGTTAAAGCTGTTGAAGCGGGTATTGATATTCTAGACACCGCAATCTCTTCTATGAGCTGTACTTAC
GGCCATACACCAACCGAAACGGTTGTTGCTATGCTAGAAGGCACAGAGCGCGACACGAATCTCAAACTAGACCAAATCGA
ACCAATCGCGGCTTACTTCCGTGATGTACGTAAAAAGTATGCGAAATGGGAAGGCCAGCTAAAAGGTGTCGATTCTCGAA
TCTTGATCGCTCAAGTTCCTGGCGGCATGTTAACCAACATGGAAGGCCAGCTTAAAGAGCAAGGCGCTGCCGATCGCATG
GATGAAGTTCTAGAAGAGATCCCACGCGTACGTAAAGAGTTGGGTTACATTCCTTTGGTAACACCTACTTCTCAGATTGT
CGGTACTCAAGCGGTTATCAACGTTCTAACGGGTGAGCGCTACAAGAGCATCACTAAAGAGACTGCGGGTCTACTGAAAG
GCGAATACGGTCAAGCTCCTGCTGAGGTTGATGCTGAACTGCAAGCGAAAGTGTTAGATGGCGCTGAGCCAATCACGTGT
CGTCCTGCTGATTTACTTAAGTCTGAAATGGATACGTTAACGACTGACCTTTTAGAAAAAGCGAAATCAGATGGTATTTC
ACTCGCTGAAGATACCGTTGATGATGTACTGACGTACGCACTATTCCCACAAGTGGGTCTTAAGTTCCTTAAAAACCGTC
ACAACCCTGAAGCGTTTGAACCTGTACCAACGGCTGAAGCTGCAACTCCTGTTGCGGCTGCACCACAACCTGCTGCTGGC
GGCATTGAGAGCTACAGCGTGAAGGTTGATGGTCAAGTTTATGATGTTGAAGTTGGCCCACAAGGTGAACTGACATCGGT
ATCTCCATCAGCGAAACCAGCACAAGCGGCTCAAGCAGCACCTGCTGCGGCTTCTGATGCAGAAGCAGTTCCTGCTCCAT
TAGCCGGCAACATCTTTAAAGTCATCGTTCAGGCGGGGGCAGAGGTTGCCGAAGGTGATGTTCTGCTGATCCTAGAAGCG
ATGAAAATGGAAACGGAAGTACGAGCTGCTCGCAGTGGTATCGTTCAAGAATTGAATGTTAAAGAAGGCGATGCAGTTAC
TGTAGGCGCTCCACTACTAAGCTTAGCGTAA

Upstream 100 bases:

>100_bases
TCAGCTGTTAGTCCACAGGTAGTGGCAGCAATTTCGGCCGCGGTTCATCAATACCGTGCGTCTACTGCTAAGTAGCATTT
AAAGGATTAAAAAGGAGTTT

Downstream 100 bases:

>100_bases
GGGAGTACCATGGAAGGATTGATGACCTTATGGTCTGAAACAGGGATTGCTAACTTTGAGTTCGGCCAGATCTGTATGAT
GTTGGTTGGTTGCTCACTGT

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKVGYWSLETWGGATFDSCIRFLGEDPWERLRELKKAMPNTP
MQMLLRGQNLLGYRHYADDVVEKFVERAHSNGMDVFRIFDAMNDVRNFETAVKATIDVGGHAQGTLSYTTSPVHNSDTWV
DLAKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAVKAVEAGIDILDTAISSMSCTY
GHTPTETVVAMLEGTERDTNLKLDQIEPIAAYFRDVRKKYAKWEGQLKGVDSRILIAQVPGGMLTNMEGQLKEQGAADRM
DEVLEEIPRVRKELGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGLLKGEYGQAPAEVDAELQAKVLDGAEPITC
RPADLLKSEMDTLTTDLLEKAKSDGISLAEDTVDDVLTYALFPQVGLKFLKNRHNPEAFEPVPTAEAATPVAAAPQPAAG
GIESYSVKVDGQVYDVEVGPQGELTSVSPSAKPAQAAQAAPAAASDAEAVPAPLAGNIFKVIVQAGAEVAEGDVLLILEA
MKMETEVRAARSGIVQELNVKEGDAVTVGAPLLSLA

Sequences:

>Translated_596_residues
MSMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKVGYWSLETWGGATFDSCIRFLGEDPWERLRELKKAMPNTP
MQMLLRGQNLLGYRHYADDVVEKFVERAHSNGMDVFRIFDAMNDVRNFETAVKATIDVGGHAQGTLSYTTSPVHNSDTWV
DLAKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAVKAVEAGIDILDTAISSMSCTY
GHTPTETVVAMLEGTERDTNLKLDQIEPIAAYFRDVRKKYAKWEGQLKGVDSRILIAQVPGGMLTNMEGQLKEQGAADRM
DEVLEEIPRVRKELGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGLLKGEYGQAPAEVDAELQAKVLDGAEPITC
RPADLLKSEMDTLTTDLLEKAKSDGISLAEDTVDDVLTYALFPQVGLKFLKNRHNPEAFEPVPTAEAATPVAAAPQPAAG
GIESYSVKVDGQVYDVEVGPQGELTSVSPSAKPAQAAQAAPAAASDAEAVPAPLAGNIFKVIVQAGAEVAEGDVLLILEA
MKMETEVRAARSGIVQELNVKEGDAVTVGAPLLSLA
>Mature_595_residues
SMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKVGYWSLETWGGATFDSCIRFLGEDPWERLRELKKAMPNTPM
QMLLRGQNLLGYRHYADDVVEKFVERAHSNGMDVFRIFDAMNDVRNFETAVKATIDVGGHAQGTLSYTTSPVHNSDTWVD
LAKRLEDLGCHSLCIKDMSGLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAVKAVEAGIDILDTAISSMSCTYG
HTPTETVVAMLEGTERDTNLKLDQIEPIAAYFRDVRKKYAKWEGQLKGVDSRILIAQVPGGMLTNMEGQLKEQGAADRMD
EVLEEIPRVRKELGYIPLVTPTSQIVGTQAVINVLTGERYKSITKETAGLLKGEYGQAPAEVDAELQAKVLDGAEPITCR
PADLLKSEMDTLTTDLLEKAKSDGISLAEDTVDDVLTYALFPQVGLKFLKNRHNPEAFEPVPTAEAATPVAAAPQPAAGG
IESYSVKVDGQVYDVEVGPQGELTSVSPSAKPAQAAQAAPAAASDAEAVPAPLAGNIFKVIVQAGAEVAEGDVLLILEAM
KMETEVRAARSGIVQELNVKEGDAVTVGAPLLSLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=625, Percent_Identity=32.96, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI106049295, Length=625, Percent_Identity=32.96, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI106049292, Length=625, Percent_Identity=32.96, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17562816, Length=624, Percent_Identity=33.3333333333333, Blast_Score=305, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6319695, Length=622, Percent_Identity=32.6366559485531, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321376, Length=612, Percent_Identity=31.5359477124183, Blast_Score=289, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24652212, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652210, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652214, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI19921944, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652216, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI281363050, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652224, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652222, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652220, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24652218, Length=621, Percent_Identity=33.9774557165861, Blast_Score=308, Evalue=6e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 64290; Mature: 64159

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKVGYWSLETWGGATFDSCIRF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
LGEDPWERLRELKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHSNGMDVFRIFD
HCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AMNDVRNFETAVKATIDVGGHAQGTLSYTTSPVHNSDTWVDLAKRLEDLGCHSLCIKDMS
HHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
GLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAVKAVEAGIDILDTAISSMSCTY
HHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GHTPTETVVAMLEGTERDTNLKLDQIEPIAAYFRDVRKKYAKWEGQLKGVDSRILIAQVP
CCCHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
GGMLTNMEGQLKEQGAADRMDEVLEEIPRVRKELGYIPLVTPTSQIVGTQAVINVLTGER
CCHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHH
YKSITKETAGLLKGEYGQAPAEVDAELQAKVLDGAEPITCRPADLLKSEMDTLTTDLLEK
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AKSDGISLAEDTVDDVLTYALFPQVGLKFLKNRHNPEAFEPVPTAEAATPVAAAPQPAAG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GIESYSVKVDGQVYDVEVGPQGELTSVSPSAKPAQAAQAAPAAASDAEAVPAPLAGNIFK
CCCCEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHH
VIVQAGAEVAEGDVLLILEAMKMETEVRAARSGIVQELNVKEGDAVTVGAPLLSLA
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCC
>Mature Secondary Structure 
SMSKPLAITDVVLRDAHQSLFATRMRIEDMLPIAAELDKVGYWSLETWGGATFDSCIRF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
LGEDPWERLRELKKAMPNTPMQMLLRGQNLLGYRHYADDVVEKFVERAHSNGMDVFRIFD
HCCCHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AMNDVRNFETAVKATIDVGGHAQGTLSYTTSPVHNSDTWVDLAKRLEDLGCHSLCIKDMS
HHHHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
GLLKPYEAEELITRIKASCDVPLALHSHATTGLSTATAVKAVEAGIDILDTAISSMSCTY
HHCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GHTPTETVVAMLEGTERDTNLKLDQIEPIAAYFRDVRKKYAKWEGQLKGVDSRILIAQVP
CCCHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
GGMLTNMEGQLKEQGAADRMDEVLEEIPRVRKELGYIPLVTPTSQIVGTQAVINVLTGER
CCHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHH
YKSITKETAGLLKGEYGQAPAEVDAELQAKVLDGAEPITCRPADLLKSEMDTLTTDLLEK
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AKSDGISLAEDTVDDVLTYALFPQVGLKFLKNRHNPEAFEPVPTAEAATPVAAAPQPAAG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GIESYSVKVDGQVYDVEVGPQGELTSVSPSAKPAQAAQAAPAAASDAEAVPAPLAGNIFK
CCCCEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHH
VIVQAGAEVAEGDVLLILEAMKMETEVRAARSGIVQELNVKEGDAVTVGAPLLSLA
HHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]