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The map label for this gene is exo I [H]

Identifier: 218710474

GI number: 218710474

Start: 2694570

End: 2696516

Strand: Direct

Name: exo I [H]

Synonym: VS_2513

Alternate gene names: 218710474

Gene position: 2694570-2696516 (Clockwise)

Preceding gene: 218710473

Following gene: 218710475

Centisome position: 81.67

GC content: 46.28

Gene sequence:

>1947_bases
ATGAATTATCGCATCGACTTAGCTGTTCTTTCTGAACAAAAAAATAACTGCCGATTTGGCCTTACGGTACATAATTTAAG
TGACCTCGACGTAAAAGATTGGTCTCTGCATTTTGCATTTGACCGATTCATCCTTCCTGAGAGTCTATCGCAAGGTGAAC
TGACTCAAGTTGGAAGCTATTGCTCGTTCAAACCAAGTTCTTCAGTATTAAAGGCCAACAACCATTACTACCTTGAATTC
AGTATTCAAAGCGCCCCATTCCGCTTCTATTCTGATGGCCTTAACGATGCCTTTATCCAGTCACATCATGATGGAGAAAC
ATCGGTACTGCCTGTCGCGATATCACCCATAGTACTGGCTTCGCCATACCGTGAACGCAATCAAATACCTGAAGTTAACG
CTTCTGAGATAGCATTGATTCCTCAACCAAATCAGATCGAACTCAAGCAAGGTAGTTTCGCGCTAAGCTGTGGATGCAAG
ATTGAGGTTCAATCTCACCTTGCAGATAAAGCCGTCTCTTGGTTGCAGCAAGAATTACTTTCTACCTTTGAACTGTCGAT
TTCGAATGAGCTTCCAACAGAATTTTCAAAAGACGAAAGCGGCGACATTCTATTTCGCAGCAATCCAACATTAGACGAAG
CAGAATACAAACTCCGCATTACTGAACAACAAATAATTGTTGAATCAGGTAGCCAGTCTGGGTTTACACACGCCGTGGCA
AGTCTGATTCAATTGATTCAACAACTGGATGCCGAAAATTTTTCTATTCCATGCTGCAAAATCGCCGATCACCCTCGCTT
TAAGTACCGAGGCATGATGTTGGACTGCGCGCGTCACTTCCACTCAGTAGAGCAAGTGAAGCGTTTAATCAATCAACTGG
CGCACTACAAGTTCAACGTATTTCATTGGCACCTAACTGACGATGAAGGTTGGAGAATTGAGATTAAGAGCCTGCCTCAG
CTGACTGAAATCGGCGCTTGGCGCGGTCCTGATCATGCATTAGAACCGCAATACACCCACCTTGCGGATAACTATGGCGG
CTTCTACACGCAGCAACAGATTCGTGAAGTCATTGAATACGCAGAGCAACGCAGCATCACGGTGATCCCAGAGATCGATA
TCCCAGGACACTGTCGCGCCGCAATAAAGTCGCTGCCTGACATGCTGGTAGAGCAAGCCGACACTACTCAATACAAGAGT
ATTCAGCACTACAACGACAATGTACTAAATCCAGGCTTGCCAGGTACTTATCAGTTCCTAGATGCTGTGATTGAAGAAGT
CGCAGAACTTTTCCCTAGCGAATTGATTCACATGGGCGCAGATGAAGTACCACCGGGCGTGTGGACCAACAGCCCTGCCG
CTCAAGCACTGATGAAAGAGCACCAGTATCAAGACAGCAAAGACCTACAAGGCCACCTATTCCGCTATGCCGAGAACAAA
CTCAAACAACTTGGTAAGCGCATGGTGGGCTGGGAAGAAGCACAGCACGGCGACAAGGTGAGCAAAGAGACCATCATCTA
TTCATGGCTCAGTGAAGAAGCCGCTATCAATTGTGCTCGCCAAGGCTTTGATGTGGTGCTGCAACCAGCACAGTTTACCT
ATCTCGACATGACCCAAGATTATGCACCGGAAGAACCGGGCGTAGATTGGGCTGCCGTTATCCCCTTAGAACAAGCTTAT
ACCTACGAAGCCCTCGCTGAGATATCCGACACCGATCCAATTCGTAAGCGGATCCGCGGAATTCAGTGTGCTCTATGGTG
TGAGATCGTTACCAATCAAAAGCGCATGGATTACATGGTATTTCCAAGAATTAGCGCTTTAGCTGAAGGATGTTGGACAC
ATAAAAACAACCGAAACTGGCTAGATTACCTATCTCGCCTAAAGGGCCACCTGCCATTACTCGACAGACTCAATGTTGAT
TATCGCAACCCTTGGAAATCTGAATAA

Upstream 100 bases:

>100_bases
ATGGATCGTTAAACCTCAATTCGACGCTATCGAAGGCGCATTGATGTTTGCCGGCAAGTCACAACACAACTTGTATCAAC
AGGCTTAGCAAGGAAGTTAT

Downstream 100 bases:

>100_bases
AACGAAACCAAAGCACACTCAAGTCGAGTACTTGCTTCCCCTGATTAAGGTGCTCAGTCAGATTCGACTCAGCATCATTA
TTTAAAAATTAGCTGCATAG

Product: N-acetyl-beta-hexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MNYRIDLAVLSEQKNNCRFGLTVHNLSDLDVKDWSLHFAFDRFILPESLSQGELTQVGSYCSFKPSSSVLKANNHYYLEF
SIQSAPFRFYSDGLNDAFIQSHHDGETSVLPVAISPIVLASPYRERNQIPEVNASEIALIPQPNQIELKQGSFALSCGCK
IEVQSHLADKAVSWLQQELLSTFELSISNELPTEFSKDESGDILFRSNPTLDEAEYKLRITEQQIIVESGSQSGFTHAVA
SLIQLIQQLDAENFSIPCCKIADHPRFKYRGMMLDCARHFHSVEQVKRLINQLAHYKFNVFHWHLTDDEGWRIEIKSLPQ
LTEIGAWRGPDHALEPQYTHLADNYGGFYTQQQIREVIEYAEQRSITVIPEIDIPGHCRAAIKSLPDMLVEQADTTQYKS
IQHYNDNVLNPGLPGTYQFLDAVIEEVAELFPSELIHMGADEVPPGVWTNSPAAQALMKEHQYQDSKDLQGHLFRYAENK
LKQLGKRMVGWEEAQHGDKVSKETIIYSWLSEEAAINCARQGFDVVLQPAQFTYLDMTQDYAPEEPGVDWAAVIPLEQAY
TYEALAEISDTDPIRKRIRGIQCALWCEIVTNQKRMDYMVFPRISALAEGCWTHKNNRNWLDYLSRLKGHLPLLDRLNVD
YRNPWKSE

Sequences:

>Translated_648_residues
MNYRIDLAVLSEQKNNCRFGLTVHNLSDLDVKDWSLHFAFDRFILPESLSQGELTQVGSYCSFKPSSSVLKANNHYYLEF
SIQSAPFRFYSDGLNDAFIQSHHDGETSVLPVAISPIVLASPYRERNQIPEVNASEIALIPQPNQIELKQGSFALSCGCK
IEVQSHLADKAVSWLQQELLSTFELSISNELPTEFSKDESGDILFRSNPTLDEAEYKLRITEQQIIVESGSQSGFTHAVA
SLIQLIQQLDAENFSIPCCKIADHPRFKYRGMMLDCARHFHSVEQVKRLINQLAHYKFNVFHWHLTDDEGWRIEIKSLPQ
LTEIGAWRGPDHALEPQYTHLADNYGGFYTQQQIREVIEYAEQRSITVIPEIDIPGHCRAAIKSLPDMLVEQADTTQYKS
IQHYNDNVLNPGLPGTYQFLDAVIEEVAELFPSELIHMGADEVPPGVWTNSPAAQALMKEHQYQDSKDLQGHLFRYAENK
LKQLGKRMVGWEEAQHGDKVSKETIIYSWLSEEAAINCARQGFDVVLQPAQFTYLDMTQDYAPEEPGVDWAAVIPLEQAY
TYEALAEISDTDPIRKRIRGIQCALWCEIVTNQKRMDYMVFPRISALAEGCWTHKNNRNWLDYLSRLKGHLPLLDRLNVD
YRNPWKSE
>Mature_648_residues
MNYRIDLAVLSEQKNNCRFGLTVHNLSDLDVKDWSLHFAFDRFILPESLSQGELTQVGSYCSFKPSSSVLKANNHYYLEF
SIQSAPFRFYSDGLNDAFIQSHHDGETSVLPVAISPIVLASPYRERNQIPEVNASEIALIPQPNQIELKQGSFALSCGCK
IEVQSHLADKAVSWLQQELLSTFELSISNELPTEFSKDESGDILFRSNPTLDEAEYKLRITEQQIIVESGSQSGFTHAVA
SLIQLIQQLDAENFSIPCCKIADHPRFKYRGMMLDCARHFHSVEQVKRLINQLAHYKFNVFHWHLTDDEGWRIEIKSLPQ
LTEIGAWRGPDHALEPQYTHLADNYGGFYTQQQIREVIEYAEQRSITVIPEIDIPGHCRAAIKSLPDMLVEQADTTQYKS
IQHYNDNVLNPGLPGTYQFLDAVIEEVAELFPSELIHMGADEVPPGVWTNSPAAQALMKEHQYQDSKDLQGHLFRYAENK
LKQLGKRMVGWEEAQHGDKVSKETIIYSWLSEEAAINCARQGFDVVLQPAQFTYLDMTQDYAPEEPGVDWAAVIPLEQAY
TYEALAEISDTDPIRKRIRGIQCALWCEIVTNQKRMDYMVFPRISALAEGCWTHKNNRNWLDYLSRLKGHLPLLDRLNVD
YRNPWKSE

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI4504373, Length=430, Percent_Identity=28.8372093023256, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI189181666, Length=417, Percent_Identity=28.7769784172662, Blast_Score=167, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17569815, Length=413, Percent_Identity=27.1186440677966, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24653074, Length=461, Percent_Identity=27.114967462039, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45551090, Length=461, Percent_Identity=27.114967462039, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24657468, Length=420, Percent_Identity=24.7619047619048, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17647501, Length=420, Percent_Identity=24.7619047619048, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI281365639, Length=420, Percent_Identity=24.7619047619048, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24657474, Length=420, Percent_Identity=24.7619047619048, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17933586, Length=488, Percent_Identity=23.7704918032787, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 74107; Mature: 74107

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYRIDLAVLSEQKNNCRFGLTVHNLSDLDVKDWSLHFAFDRFILPESLSQGELTQVGSY
CCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHCCCCCCCCCCHHHHCCC
CSFKPSSSVLKANNHYYLEFSIQSAPFRFYSDGLNDAFIQSHHDGETSVLPVAISPIVLA
CCCCCCCCEEECCCEEEEEEEECCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEECCEEEE
SPYRERNQIPEVNASEIALIPQPNQIELKQGSFALSCGCKIEVQSHLADKAVSWLQQELL
CCCHHHCCCCCCCCCCEEEECCCCEEEEECCCEEEECCEEEEHHHHHHHHHHHHHHHHHH
STFELSISNELPTEFSKDESGDILFRSNPTLDEAEYKLRITEQQIIVESGSQSGFTHAVA
HHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHH
SLIQLIQQLDAENFSIPCCKIADHPRFKYRGMMLDCARHFHSVEQVKRLINQLAHYKFNV
HHHHHHHHHCCCCCCCCEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
FHWHLTDDEGWRIEIKSLPQLTEIGAWRGPDHALEPQYTHLADNYGGFYTQQQIREVIEY
EEEEEECCCCCEEEECCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHH
AEQRSITVIPEIDIPGHCRAAIKSLPDMLVEQADTTQYKSIQHYNDNVLNPGLPGTYQFL
HHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
DAVIEEVAELFPSELIHMGADEVPPGVWTNSPAAQALMKEHQYQDSKDLQGHLFRYAENK
HHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKQLGKRMVGWEEAQHGDKVSKETIIYSWLSEEAAINCARQGFDVVLQPAQFTYLDMTQD
HHHHHHHHCCCHHHHCCCCCCHHHEEEHHHHHHHHHHHHHCCCCEEECCCCEEEEECHHC
YAPEEPGVDWAAVIPLEQAYTYEALAEISDTDPIRKRIRGIQCALWCEIVTNQKRMDYMV
CCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEHHHHCCCCCCCEEE
FPRISALAEGCWTHKNNRNWLDYLSRLKGHLPLLDRLNVDYRNPWKSE
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNYRIDLAVLSEQKNNCRFGLTVHNLSDLDVKDWSLHFAFDRFILPESLSQGELTQVGSY
CCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEHHHHCCCCCCCCCCHHHHCCC
CSFKPSSSVLKANNHYYLEFSIQSAPFRFYSDGLNDAFIQSHHDGETSVLPVAISPIVLA
CCCCCCCCEEECCCEEEEEEEECCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEECCEEEE
SPYRERNQIPEVNASEIALIPQPNQIELKQGSFALSCGCKIEVQSHLADKAVSWLQQELL
CCCHHHCCCCCCCCCCEEEECCCCEEEEECCCEEEECCEEEEHHHHHHHHHHHHHHHHHH
STFELSISNELPTEFSKDESGDILFRSNPTLDEAEYKLRITEQQIIVESGSQSGFTHAVA
HHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHH
SLIQLIQQLDAENFSIPCCKIADHPRFKYRGMMLDCARHFHSVEQVKRLINQLAHYKFNV
HHHHHHHHHCCCCCCCCEEECCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
FHWHLTDDEGWRIEIKSLPQLTEIGAWRGPDHALEPQYTHLADNYGGFYTQQQIREVIEY
EEEEEECCCCCEEEECCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHH
AEQRSITVIPEIDIPGHCRAAIKSLPDMLVEQADTTQYKSIQHYNDNVLNPGLPGTYQFL
HHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
DAVIEEVAELFPSELIHMGADEVPPGVWTNSPAAQALMKEHQYQDSKDLQGHLFRYAENK
HHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKQLGKRMVGWEEAQHGDKVSKETIIYSWLSEEAAINCARQGFDVVLQPAQFTYLDMTQD
HHHHHHHHCCCHHHHCCCCCCHHHEEEHHHHHHHHHHHHHCCCCEEECCCCEEEEECHHC
YAPEEPGVDWAAVIPLEQAYTYEALAEISDTDPIRKRIRGIQCALWCEIVTNQKRMDYMV
CCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEHHHHCCCCCCCEEE
FPRISALAEGCWTHKNNRNWLDYLSRLKGHLPLLDRLNVDYRNPWKSE
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]