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The map label for this gene is upp [H]

Identifier: 218710283

GI number: 218710283

Start: 2484193

End: 2484834

Strand: Reverse

Name: upp [H]

Synonym: VS_2317

Alternate gene names: 218710283

Gene position: 2484834-2484193 (Counterclockwise)

Preceding gene: 218710286

Following gene: 218710281

Centisome position: 75.31

GC content: 43.77

Gene sequence:

>642_bases
TTGCCGGAGTTGGAAATGAAAGTTGTTGAAGTGAAACACCCGCTAGTAAAACATAAAATTGGCCTGATGCGTGAAGGTGA
CATTAGTACTAAGCGTTTTCGTGAGCTAGCGACAGAAGTGGGTAGCCTTCTAACATACGAAGCGACATCAGACTTTGAAA
CTGAACGTGTAACTATTGATGGTTGGAACGGCCCAGTAGAAGTTGACCAAATTAAAGGTAAAAAGGTAACAGTAGTGCCA
ATCCTACGTGCAGGTCTAGGCATGATGGATGGTGTTTTAGAGCATATGCCAAGTGCTCGAATCAGTGTCGTGGGTATCTA
CCGTGACGAAGAAACATTAGAGCCTGTACCATACTTCAACAAGCTAGCATCTAACATTGATGAGCGTATTGCTCTAGTGG
TTGATCCAATGTTAGCAACTGGCGGTTCTATGATTGCAACTCTTGACCTTCTAAAAGAGCAAGGCTGTAAAGTATTTAAA
GTACTGGTACTTGTTGCTGCCCCTGAAGGTATCGCTGCACTAGAAAAAGCGCACCCAGATGTTGAGCTTTACACTGCTGC
AATCGATGAGAAGCTAAACGACAAGGGCTACATTGTTCCTGGTCTTGGTGATGCTGGTGATAAGATCTTCGGTACTAAGT
AA

Upstream 100 bases:

>100_bases
TTGATTACGAAGAGCAAACGTTTGCGCGGTTTTTTTTATTAGAATAAAGATTCTGAAATAACCCCACAGTTCGTGTATAA
TCTACAGGTTTGTTTAAATA

Downstream 100 bases:

>100_bases
TTCGGTTTCAGCTTAAGTGACGCTAAACCGTTTCTTAACTCGCTGAATTAGCCGTATTAATAAAAAGGGAGAGCATTCGA
TGCTCTCCCTTTTTTGATCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MPELEMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETERVTIDGWNGPVEVDQIKGKKVTVVP
ILRAGLGMMDGVLEHMPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEQGCKVFK
VLVLVAAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK

Sequences:

>Translated_213_residues
MPELEMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETERVTIDGWNGPVEVDQIKGKKVTVVP
ILRAGLGMMDGVLEHMPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEQGCKVFK
VLVLVAAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
>Mature_212_residues
PELEMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETERVTIDGWNGPVEVDQIKGKKVTVVPI
LRAGLGMMDGVLEHMPSARISVVGIYRDEETLEPVPYFNKLASNIDERIALVVDPMLATGGSMIATLDLLKEQGCKVFKV
LVLVAAPEGIAALEKAHPDVELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=143, Percent_Identity=31.4685314685315, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI57863312, Length=143, Percent_Identity=31.4685314685315, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=85.0961538461538, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.3781094527363, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=41.304347826087, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.0935960591133, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.0935960591133, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.0935960591133, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.0935960591133, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23258; Mature: 23127

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELEMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETERVTID
CCCCCEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
GWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHMPSARISVVGIYRDEETLEPVPYFN
CCCCCEEHEECCCCEEEEEHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHH
KLASNIDERIALVVDPMLATGGSMIATLDLLKEQGCKVFKVLVLVAAPEGIAALEKAHPD
HHHHHHHHHHHHEECHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCC
VELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
CEEHHHHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PELEMKVVEVKHPLVKHKIGLMREGDISTKRFRELATEVGSLLTYEATSDFETERVTID
CCCCEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
GWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHMPSARISVVGIYRDEETLEPVPYFN
CCCCCEEHEECCCCEEEEEHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHH
KLASNIDERIALVVDPMLATGGSMIATLDLLKEQGCKVFKVLVLVAAPEGIAALEKAHPD
HHHHHHHHHHHHEECHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHCCCC
VELYTAAIDEKLNDKGYIVPGLGDAGDKIFGTK
CEEHHHHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA