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The map label for this gene is lon [H]

Identifier: 218710172

GI number: 218710172

Start: 2351013

End: 2353364

Strand: Reverse

Name: lon [H]

Synonym: VS_2203

Alternate gene names: 218710172

Gene position: 2353364-2351013 (Counterclockwise)

Preceding gene: 218710173

Following gene: 218710171

Centisome position: 71.33

GC content: 45.2

Gene sequence:

>2352_bases
ATGAACTTGGAACGTTCCGAGCGTATCGAAATCCCCGTGCTACCTCTACGTGATGTAGTGGTTTACCCACACATGGTTAT
TCCATTGTTTGTTGGTCGTGAAAAATCGATTACTTGCCTTGAATCGGCAATGGAAGCTAACAAACAAGTACTACTTGTAG
CGCAGAAAGAAGCGGACACTGATGAGCCTTCAATCGACGACCTATTTAACGTAGGTACAGTCGCTACTATTCTTCAGTTG
CTAAAGCTGCCAGATGGTACCGTAAAAGTACTTGTCGAAGGTCAGCAGCGTGCAAAAATTCACCAGTTCAAAGAGAGTGA
GTTTTTCTTAGCGGATGCCGAATACGTTGTAACCTCAGAACTTGACGAAAAAGAACAAGAAGTGGTTGTTCGCAGTGCGA
TCAATCAATTCGAAGGCTTTATTAAGCTGAACAAAAAGATTCCACCAGAGGTTCTAACCTCGCTGAACGGTATTGATGAG
GCTGCTCGCCTTGCTGATACGATTGCTGCGCACATGCCACTTAAACTGGTAGATAAGCAGCACGTTCTAGAAATTTCAGA
TGTGACGGAACGCCTGGAATTCTTGATGGGCCAAATGGAGTCAGAAATTGATATCCTGCAAGTTGAAAAACGCATCCGTG
GCCGCGTTAAGAAACAGATGGAAAAGTCTCAGCGTGAGTACTATCTGAATGAGCAAATGAAAGCGATTCAGAAAGAACTG
GGCGAGATGGACGACGCGCCTGATGAATTCGAGACTCTGAAGAAGAAGATCGAAGACTCAAAAATGCCTCAAGAAGCTCG
TGAAAAAACTGAGCAAGAATTGCAAAAACTGAAAATGATGTCGCCAATGTCTGCTGAAGCAACAGTAGTACGTAGTTACA
TTGATTGGATGGTAGGCGTTCCTTGGGCTAAGCGTTCAAAAGTTAAAAAGAATTTAGCGAAAGCGGAAGAGATCTTAAAC
GAAGATCACTACGGCTTAGAGCGTGTTAAAGAACGTATTCTCGAATACTTGGCAGTACAAAACCGTATCAACAAACTAAA
AGGCCCAATCCTTTGTCTTGTTGGTCCTCCTGGTGTTGGTAAAACTTCACTAGGCCGTTCGATTGCCGCGGCAACGGGTC
GTAAGTACACACGTATGGCGCTAGGCGGCGTTCGTGATGAAGCTGAGATTCGTGGTCACCGTCGTACGTACATCGGTTCA
CTTCCGGGTAAATTAATCCAGAAGATGTCTAAAGTTGGTGTTAAGAACCCACTGTTCCTATTAGATGAAATCGATAAGAT
GTCTTCTGATATGCGTGGCGACCCATCTTCTGCGCTTCTAGAAGTACTAGACCCTGAGCAAAACAACGCATTTAACGATC
ACTACCTAGAAGTCGATTACGATTTATCTGATGTGATGTTTGTTGCAACGTCTAACTCGATGGATATTCCGGGCCCACTA
TTGGACCGTATGGAAGTGATTCGCCTGTCGGGTTACACAGAAGATGAAAAGCTGAACATTGCCAAGAGCCACCTATTGGA
CAAGCAAGTTCAACGCAACGGTCTTAAGCCTCATGAGATTGAGATTGAAGACTCTGCAATCATCGGCATCATTCGTTACT
ACACGCGTGAAGCGGGTGTGCGTAGCCTAGAGCGTGAAATCTCTAAGATCTGTCGTAAAGCAGTGAAGAATATCTTGTTA
GACAGCGACCTTAAATCTGTAACGGTTAACATTGATAACCTGAAAGAGTACTTAGGTGTGCAACGTCATGACTTCGGTAA
AGCGGATGAAAGCAACCGTATCGGCCAAGTAACTGGCTTAGCATGGACGCAAGTAGGTGGCGATCTACTGACCATCGAAA
CTGAATCAATGCCAGGTAAAGGTAAGCTAACGCAAACCGGTTCACTAGGCGATGTGATGAAAGAGTCGATTCAAGCGGCA
ATGACAGTGGTTCGCTCTCGTGCGGAAAATTTGGGTATTAACACCGATTTCTACGAGAAACGTGACATTCATGTTCACGT
ACCGGAAGGTGCAACGCCAAAAGATGGCCCGAGTGCGGGTATCGCAATGTGTACTGCATTGGTCTCTAGCTTAACGGGTA
ACCCTGTAAAAGCAGAGGTTGGTATGACCGGTGAAATTACCCTTCGTGGTGAAGTTTTACCTATCGGTGGCTTGAAAGAA
AAGCTGCTTGCAGCGCACCGCGGTGGTATTAAAACGGTCTTGATTCCTAAAGACAATGAACGTGATTTGGAAGAGATTCC
AGACAACGTAATCGCTGACTTGAAGGTGATTCCGGTTCAATGGATTGATGAAGTACTGAAAGTCGCACTAGAACGAGATC
CGTCAGGGGTCGAGTTCGACGTGAAAAAATAG

Upstream 100 bases:

>100_bases
AGGAGGTAAGCAATTACCTCCTTTTTTTTATTCTTCCATTGAATCCAGTCGTTTAAGCCCCATATACTGCTTTATAAGTT
AAAGCGGAAGAGAGAAATAT

Downstream 100 bases:

>100_bases
TGATGCATAGCAAAAATAAGTAAAGAATTACGCTGATAGACCCGAAAAGGCTTGTCAGCGTTTTTTTTGGACGCTAAGTT
ATTCGACTAAAGCGGCAGCC

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSITCLESAMEANKQVLLVAQKEADTDEPSIDDLFNVGTVATILQL
LKLPDGTVKVLVEGQQRAKIHQFKESEFFLADAEYVVTSELDEKEQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDE
AARLADTIAAHMPLKLVDKQHVLEISDVTERLEFLMGQMESEIDILQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GEMDDAPDEFETLKKKIEDSKMPQEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVGVPWAKRSKVKKNLAKAEEILN
EDHYGLERVKERILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPSSALLEVLDPEQNNAFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKSHLLDKQVQRNGLKPHEIEIEDSAIIGIIRYYTREAGVRSLEREISKICRKAVKNILL
DSDLKSVTVNIDNLKEYLGVQRHDFGKADESNRIGQVTGLAWTQVGGDLLTIETESMPGKGKLTQTGSLGDVMKESIQAA
MTVVRSRAENLGINTDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVGMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPSGVEFDVKK

Sequences:

>Translated_783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSITCLESAMEANKQVLLVAQKEADTDEPSIDDLFNVGTVATILQL
LKLPDGTVKVLVEGQQRAKIHQFKESEFFLADAEYVVTSELDEKEQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDE
AARLADTIAAHMPLKLVDKQHVLEISDVTERLEFLMGQMESEIDILQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GEMDDAPDEFETLKKKIEDSKMPQEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVGVPWAKRSKVKKNLAKAEEILN
EDHYGLERVKERILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPSSALLEVLDPEQNNAFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKSHLLDKQVQRNGLKPHEIEIEDSAIIGIIRYYTREAGVRSLEREISKICRKAVKNILL
DSDLKSVTVNIDNLKEYLGVQRHDFGKADESNRIGQVTGLAWTQVGGDLLTIETESMPGKGKLTQTGSLGDVMKESIQAA
MTVVRSRAENLGINTDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVGMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPSGVEFDVKK
>Mature_783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSITCLESAMEANKQVLLVAQKEADTDEPSIDDLFNVGTVATILQL
LKLPDGTVKVLVEGQQRAKIHQFKESEFFLADAEYVVTSELDEKEQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDE
AARLADTIAAHMPLKLVDKQHVLEISDVTERLEFLMGQMESEIDILQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GEMDDAPDEFETLKKKIEDSKMPQEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVGVPWAKRSKVKKNLAKAEEILN
EDHYGLERVKERILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVGVKNPLFLLDEIDKMSSDMRGDPSSALLEVLDPEQNNAFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
LDRMEVIRLSGYTEDEKLNIAKSHLLDKQVQRNGLKPHEIEIEDSAIIGIIRYYTREAGVRSLEREISKICRKAVKNILL
DSDLKSVTVNIDNLKEYLGVQRHDFGKADESNRIGQVTGLAWTQVGGDLLTIETESMPGKGKLTQTGSLGDVMKESIQAA
MTVVRSRAENLGINTDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVGMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPSGVEFDVKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=38.8387096774194, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=829, Percent_Identity=34.9819059107358, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1786643, Length=779, Percent_Identity=81.1296534017972, Blast_Score=1288, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=657, Percent_Identity=40.1826484018265, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=799, Percent_Identity=33.7922403003755, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=40.5925925925926, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=620, Percent_Identity=44.5161290322581, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=620, Percent_Identity=44.5161290322581, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87613; Mature: 87613

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSITCLESAMEANKQVLLVAQKEADT
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCC
DEPSIDDLFNVGTVATILQLLKLPDGTVKVLVEGQQRAKIHQFKESEFFLADAEYVVTSE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCEEECCC
LDEKEQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDEAARLADTIAAHMPLKLVDKQ
CCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCHH
HVLEISDVTERLEFLMGQMESEIDILQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMDDAPDEFETLKKKIEDSKMPQEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWAKRSKVKKNLAKAEEILNEDHYGLERVKERILEYLAVQNRINKLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGRSIAAATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMSKVGVKNPLFL
CHHHCCHHHHHCCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPSSALLEVLDPEQNNAFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHH
LDRMEVIRLSGYTEDEKLNIAKSHLLDKQVQRNGLKPHEIEIEDSAIIGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNILLDSDLKSVTVNIDNLKEYLGVQRHDFGKADESNRIGQVTGL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
AWTQVGGDLLTIETESMPGKGKLTQTGSLGDVMKESIQAAMTVVRSRAENLGINTDFYEK
EHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVGMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECEEEECCCHHH
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPSGVEFD
HHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCCCEEE
VKK
CCC
>Mature Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSITCLESAMEANKQVLLVAQKEADT
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCC
DEPSIDDLFNVGTVATILQLLKLPDGTVKVLVEGQQRAKIHQFKESEFFLADAEYVVTSE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCEEECCC
LDEKEQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDEAARLADTIAAHMPLKLVDKQ
CCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCHHHHCHH
HVLEISDVTERLEFLMGQMESEIDILQVEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMDDAPDEFETLKKKIEDSKMPQEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWAKRSKVKKNLAKAEEILNEDHYGLERVKERILEYLAVQNRINKLKGPILCLVGPPGVG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGRSIAAATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMSKVGVKNPLFL
CHHHCCHHHHHCCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPSSALLEVLDPEQNNAFNDHYLEVDYDLSDVMFVATSNSMDIPGPL
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHH
LDRMEVIRLSGYTEDEKLNIAKSHLLDKQVQRNGLKPHEIEIEDSAIIGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNILLDSDLKSVTVNIDNLKEYLGVQRHDFGKADESNRIGQVTGL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
AWTQVGGDLLTIETESMPGKGKLTQTGSLGDVMKESIQAAMTVVRSRAENLGINTDFYEK
EHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVGMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECEEEECCCHHH
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPSGVEFD
HHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHHCCCCCCEEE
VKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]