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The map label for this gene is mdtA [H]

Identifier: 218710149

GI number: 218710149

Start: 2324608

End: 2325699

Strand: Reverse

Name: mdtA [H]

Synonym: VS_2172

Alternate gene names: 218710149

Gene position: 2325699-2324608 (Counterclockwise)

Preceding gene: 218710150

Following gene: 218710148

Centisome position: 70.49

GC content: 45.51

Gene sequence:

>1092_bases
TTGCAGACCATTATTATGAAGCATAAAACTGTTTTAACCCTGCTTAGCTTGTCTATCATTATGGCGTCTCCAGCCGCACT
AGCTAAACGTATGGGCCCTAGCACGGTCACTGTTGTTACCGAGCAAGTTGATATTCACCAAGTTAGTCAGTCTCTTTCTT
TGGTCGGTAAGTTGGAAGCCGAGCAATCTGTAATGATCACTTCCGAAGTGGCTGGCAGAGTGAACTCTATTAACATCAAA
GCCAATCAAGATGTCACCAAAGGGCAGATGTTGGTTCAACTCGATGACGACAAAGCAAAAGCTGCAGTTGCAGAAGCACA
AGCATATTTAAAAGATGAAAAGCGTAAGCTTGCAGAATTTCAACGACTAGTGAAACGTAACGCGATCACTCAAACTGAAA
TTGACGCTCAGAAAACTAACGTAGAGATCGCCAATGCTCGTCTAGCTGCCGCTAATGCCAACCTGAAAGATCTACATATC
AGTGCACCTTTCTCTGGTACGGTCGGTTTTATTGACTTTAGCCGCGGCAAAATGGTGACATCGGGTACAGAGCTCGTGAC
GTTAGATGACTTGTCTGTGATGCAGTTAGATCTTCAGATTCCAGAGCGCTACCTTTCTAAACTGTCTAAAGGTATGACAG
TAACGGCTCGCACCAGTGCGTGGGGCGATACTCAGTTCACGGGTACTGTGGTGGGTATTGATTCTCGCATTAACGCCGAA
ACGTTGAACCTTCGAGTTCGAATCCACTTCGATAACAACAATGATTACCTAAAACCGGGCATGTTAGTGGCGGCTGATAT
GGACTTCCCACCAGTAGAAGCCCCAATCATTCCAGTTCAAGCGCTTGAGTATTCAGGCACCAAGCGTTTCGTTTATGTTA
TTGGCGAAGATAACAAAGCGACTCGTACCGAAGTATTCCTCGGGGCTCGTCTTGATAACGAAGTCGTGATCGAAAAAGGC
ATCGAGATTGGTCAGAAGATCGTAGTGCAAGGTATCGTGAACATGCGTGACGGTGTTTTGGTTCAAGAACTTGCCGTTAA
TCGCCCTGCTAAACTTGATGAAAATACAGCAGCACAAGAAGGCTCTAACTAA

Upstream 100 bases:

>100_bases
ACTTATCGAAACTATCTGTTGAAAAGAGCTGCCTTGTTCTCAAGTCTTTTCCCTGCGCTATTTCTGACCACTTACCTACT
GTGATTGGTATAAACCTTAC

Downstream 100 bases:

>100_bases
TGTTGTTATCTGATGTTTCTGTGAAGAGACCAGTAGCGGCTGTTGTATTGAGCCTGCTTTTGGTTGTGTTTGGTATTGTC
TCTTTCAATAAACTCGCAGT

Product: AcrA, membrane-fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MQTIIMKHKTVLTLLSLSIIMASPAALAKRMGPSTVTVVTEQVDIHQVSQSLSLVGKLEAEQSVMITSEVAGRVNSINIK
ANQDVTKGQMLVQLDDDKAKAAVAEAQAYLKDEKRKLAEFQRLVKRNAITQTEIDAQKTNVEIANARLAAANANLKDLHI
SAPFSGTVGFIDFSRGKMVTSGTELVTLDDLSVMQLDLQIPERYLSKLSKGMTVTARTSAWGDTQFTGTVVGIDSRINAE
TLNLRVRIHFDNNNDYLKPGMLVAADMDFPPVEAPIIPVQALEYSGTKRFVYVIGEDNKATRTEVFLGARLDNEVVIEKG
IEIGQKIVVQGIVNMRDGVLVQELAVNRPAKLDENTAAQEGSN

Sequences:

>Translated_363_residues
MQTIIMKHKTVLTLLSLSIIMASPAALAKRMGPSTVTVVTEQVDIHQVSQSLSLVGKLEAEQSVMITSEVAGRVNSINIK
ANQDVTKGQMLVQLDDDKAKAAVAEAQAYLKDEKRKLAEFQRLVKRNAITQTEIDAQKTNVEIANARLAAANANLKDLHI
SAPFSGTVGFIDFSRGKMVTSGTELVTLDDLSVMQLDLQIPERYLSKLSKGMTVTARTSAWGDTQFTGTVVGIDSRINAE
TLNLRVRIHFDNNNDYLKPGMLVAADMDFPPVEAPIIPVQALEYSGTKRFVYVIGEDNKATRTEVFLGARLDNEVVIEKG
IEIGQKIVVQGIVNMRDGVLVQELAVNRPAKLDENTAAQEGSN
>Mature_363_residues
MQTIIMKHKTVLTLLSLSIIMASPAALAKRMGPSTVTVVTEQVDIHQVSQSLSLVGKLEAEQSVMITSEVAGRVNSINIK
ANQDVTKGQMLVQLDDDKAKAAVAEAQAYLKDEKRKLAEFQRLVKRNAITQTEIDAQKTNVEIANARLAAANANLKDLHI
SAPFSGTVGFIDFSRGKMVTSGTELVTLDDLSVMQLDLQIPERYLSKLSKGMTVTARTSAWGDTQFTGTVVGIDSRINAE
TLNLRVRIHFDNNNDYLKPGMLVAADMDFPPVEAPIIPVQALEYSGTKRFVYVIGEDNKATRTEVFLGARLDNEVVIEKG
IEIGQKIVVQGIVNMRDGVLVQELAVNRPAKLDENTAAQEGSN

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=366, Percent_Identity=27.5956284153005, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87081796, Length=367, Percent_Identity=25.6130790190736, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789665, Length=377, Percent_Identity=25.7294429708223, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081951, Length=148, Percent_Identity=34.4594594594595, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39591; Mature: 39591

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIIMKHKTVLTLLSLSIIMASPAALAKRMGPSTVTVVTEQVDIHQVSQSLSLVGKLEA
CCEEEEHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCC
EQSVMITSEVAGRVNSINIKANQDVTKGQMLVQLDDDKAKAAVAEAQAYLKDEKRKLAEF
CCEEEEEHHHCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
QRLVKRNAITQTEIDAQKTNVEIANARLAAANANLKDLHISAPFSGTVGFIDFSRGKMVT
HHHHHHCCCCCCCCCCHHCCEEEECEEEEECCCCCEEEEEECCCCCCEEEEEECCCEEEE
SGTELVTLDDLSVMQLDLQIPERYLSKLSKGMTVTARTSAWGDTQFTGTVVGIDSRINAE
CCCEEEEECCCEEEEEEECCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCE
TLNLRVRIHFDNNNDYLKPGMLVAADMDFPPVEAPIIPVQALEYSGTKRFVYVIGEDNKA
EEEEEEEEEECCCCCEECCCEEEEECCCCCCCCCCEEEEEEEEECCCEEEEEEEECCCCC
TRTEVFLGARLDNEVVIEKGIEIGQKIVVQGIVNMRDGVLVQELAVNRPAKLDENTAAQE
EEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCC
GSN
CCC
>Mature Secondary Structure
MQTIIMKHKTVLTLLSLSIIMASPAALAKRMGPSTVTVVTEQVDIHQVSQSLSLVGKLEA
CCEEEEHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHCCCC
EQSVMITSEVAGRVNSINIKANQDVTKGQMLVQLDDDKAKAAVAEAQAYLKDEKRKLAEF
CCEEEEEHHHCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
QRLVKRNAITQTEIDAQKTNVEIANARLAAANANLKDLHISAPFSGTVGFIDFSRGKMVT
HHHHHHCCCCCCCCCCHHCCEEEECEEEEECCCCCEEEEEECCCCCCEEEEEECCCEEEE
SGTELVTLDDLSVMQLDLQIPERYLSKLSKGMTVTARTSAWGDTQFTGTVVGIDSRINAE
CCCEEEEECCCEEEEEEECCHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCE
TLNLRVRIHFDNNNDYLKPGMLVAADMDFPPVEAPIIPVQALEYSGTKRFVYVIGEDNKA
EEEEEEEEEECCCCCEECCCEEEEECCCCCCCCCCEEEEEEEEECCCEEEEEEEECCCCC
TRTEVFLGARLDNEVVIEKGIEIGQKIVVQGIVNMRDGVLVQELAVNRPAKLDENTAAQE
EEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCCC
GSN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA