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The map label for this gene is soxR [H]

Identifier: 218710112

GI number: 218710112

Start: 2291253

End: 2291693

Strand: Reverse

Name: soxR [H]

Synonym: VS_2133

Alternate gene names: 218710112

Gene position: 2291693-2291253 (Counterclockwise)

Preceding gene: 218710113

Following gene: 218710111

Centisome position: 69.46

GC content: 48.53

Gene sequence:

>441_bases
ATGAGAAACATCGTATACCTCACCATAGGCCAATTGGCGGAGCGAAGTGGTGTGGCACCTTCAGCGCTGCGCTTTTATGA
AACCAAAGGGTTGATTGCTTCGATTCGTACTAACGGAAATCAACGCCGGTATCAGTCGGCGATGTTGAGACGAATTGCGT
TGATACAAGTCGCGCAGTCGATAGGCTTCACGCTCGAAGAGATCACCGAAGAGTTATCAACACTGCCAATGAACCATACC
GCGACTAAGCGAGATTGGGAACGCGTTGCGAAGAAATGGCAGGGGCAACTGGACAGCAAGATGGCGCAGATTAAATCGCT
ACAAGAAAACCTAACTGGTTGTATTGGTTGCGGGTGTTTGAGTATGCAGAAATGCCAATTGTTGAACCCTGAAGATATTC
TGCATGACCAAGGACAGGGCGCACAACGCATTGTTGATTAG

Upstream 100 bases:

>100_bases
CCCAAACCTAAGTTTGAACCCAAACTTCAAGTTAAAGTGAACTCTATTATACTGGTTATTATCAGGAAGAAACGGCTATT
CAAACAGGAAGTGAAAGATC

Downstream 100 bases:

>100_bases
ACTAACTGAGTTCCTGATGGAAACAAGATCTGTGGAACTCACTTTATGCCATAGTGGCGTATACTTATACCATAATGGCT
TATACTTAGATGACATGGAC

Product: redox-sensitive transcriptional activator soxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MRNIVYLTIGQLAERSGVAPSALRFYETKGLIASIRTNGNQRRYQSAMLRRIALIQVAQSIGFTLEEITEELSTLPMNHT
ATKRDWERVAKKWQGQLDSKMAQIKSLQENLTGCIGCGCLSMQKCQLLNPEDILHDQGQGAQRIVD

Sequences:

>Translated_146_residues
MRNIVYLTIGQLAERSGVAPSALRFYETKGLIASIRTNGNQRRYQSAMLRRIALIQVAQSIGFTLEEITEELSTLPMNHT
ATKRDWERVAKKWQGQLDSKMAQIKSLQENLTGCIGCGCLSMQKCQLLNPEDILHDQGQGAQRIVD
>Mature_146_residues
MRNIVYLTIGQLAERSGVAPSALRFYETKGLIASIRTNGNQRRYQSAMLRRIALIQVAQSIGFTLEEITEELSTLPMNHT
ATKRDWERVAKKWQGQLDSKMAQIKSLQENLTGCIGCGCLSMQKCQLLNPEDILHDQGQGAQRIVD

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=140, Percent_Identity=48.5714285714286, Blast_Score=148, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16407; Mature: 16407

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIVYLTIGQLAERSGVAPSALRFYETKGLIASIRTNGNQRRYQSAMLRRIALIQVAQS
CCCEEEEEHHHHHHHCCCCHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
IGFTLEEITEELSTLPMNHTATKRDWERVAKKWQGQLDSKMAQIKSLQENLTGCIGCGCL
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMQKCQLLNPEDILHDQGQGAQRIVD
HHHHHCCCCHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MRNIVYLTIGQLAERSGVAPSALRFYETKGLIASIRTNGNQRRYQSAMLRRIALIQVAQS
CCCEEEEEHHHHHHHCCCCHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHH
IGFTLEEITEELSTLPMNHTATKRDWERVAKKWQGQLDSKMAQIKSLQENLTGCIGCGCL
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMQKCQLLNPEDILHDQGQGAQRIVD
HHHHHCCCCHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]