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The map label for this gene is bioA [H]

Identifier: 218710021

GI number: 218710021

Start: 2186949

End: 2188232

Strand: Direct

Name: bioA [H]

Synonym: VS_2041

Alternate gene names: 218710021

Gene position: 2186949-2188232 (Clockwise)

Preceding gene: 218710016

Following gene: 218710022

Centisome position: 66.29

GC content: 47.27

Gene sequence:

>1284_bases
ATGGATCTCGCCTTTGACCGCCAGCATATCTGGCATCCTTATACATCAACGTTGACACCTCTGACCTGCTACCCAGTCAC
TAACGCAGACGGCGTTTACCTAGAATTAGAGGGCGGAAAACGAATTATTGATGGTATGTCCTCTTGGTGGTCAACCATCC
ACGGCTACAATCATCCAGAGCTCAATGCTGCAGCTCACAGCCAAATCGATAAGGTTTCGCATGTTATGTTTGGAGGTATC
ACCCACCAGCCTGCTATCGATTTATGTAAGAAACTTTTGAACCTAGCACCAAATAATCTCGAGCACGTATTCTTGGCTGA
TTCAGGTTCAGTAGCCGTAGAGGTTAGTCTCAAGATGGCTCTCCAATACTGGCACGCTAAAGGGCAACCTCGTTCAAAAC
TCCTCACGTTGAGAGATGGTTACCACGGTGATACCTTTGCGGCAATGTCAGTGACCGATCCAGATAACTCGATGCACAGC
CTCTACAAAGGCTTTTTGCCTGAGCACATTTTTGCTGATTCGCCAAAAACGAGGTTTTGGGATCAATGGGACGAAAACGA
CATCAACAGCTTTCGAGAAAAGCTGGCAAATCACCATCAAGAAGTTGCTGCCGTGATCTTAGAGCCTATCGTTCAAGGCG
CTGGCGGCATGCGCATCTACCATCCTGAATTCCTGAGACAGGTTCGCTTGCTGTGTGATGAATTCAACGTATTACTTATT
TTGGATGAGATTGCAACCGGGTTTGGTCGCACAGGGAAACTGTTCGCTTGTGAGCATGCCGATGTCAAACCGGACATCTT
ATGCGTAGGCAAGGCTTTAACTGGTGGCTATATGACATTGTCAGCGACGCTTGCGAGTAAAGAAGTTGCTGACACGGTAT
GTGGCGGTGAAGCAGGCTGCTTTATGCACGGGCCAACCTTCATGGGCAACCCTTTAGCTTGTGCAGTAGGTGCGGCAAGT
TTGTCCATCATAGAGCAAGGTCATTGGCAAAATCAGACTCATCAGATTGAACAACTCTTTTCTGAGTTACTACCGCCTCT
ACTCAAGCATGCTCTTGTCAAAGATGTTCGCTGGTTGGGCGCTATTGGCGTCGTTGAAACCCACACACCTGTCGATATGG
AAACCATCCAAGCTCACTTTGTTGAACAAGGCGTTTGGATACGTCCGTTCGGGAAGTTGATTTATATGATGCCTCCTTTC
ATTAGCAAGGCTGAGCACATCGAACAACTTGTTTCATCTATTGATAAAGCCCTCCAACAATCTGCTTGCTTCAAACCAAG
TTGA

Upstream 100 bases:

>100_bases
CTTGGATAGTCTACCGACAAGCTTTAGACTGTCAACACATTGATAATATCAAAAGTTTACATCTGGTTGTTTTTTAACCA
CACCAAGAATGGAAGTTACT

Downstream 100 bases:

>100_bases
TTTAACAAACATCATTTAGAAAACCTATAAGCCGCCCATAAAAGACTAATGGCGGCTTCTCCTTCACGTGAAAAACCAGC
CAACAAACATACCCCAAGCC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MDLAFDRQHIWHPYTSTLTPLTCYPVTNADGVYLELEGGKRIIDGMSSWWSTIHGYNHPELNAAAHSQIDKVSHVMFGGI
THQPAIDLCKKLLNLAPNNLEHVFLADSGSVAVEVSLKMALQYWHAKGQPRSKLLTLRDGYHGDTFAAMSVTDPDNSMHS
LYKGFLPEHIFADSPKTRFWDQWDENDINSFREKLANHHQEVAAVILEPIVQGAGGMRIYHPEFLRQVRLLCDEFNVLLI
LDEIATGFGRTGKLFACEHADVKPDILCVGKALTGGYMTLSATLASKEVADTVCGGEAGCFMHGPTFMGNPLACAVGAAS
LSIIEQGHWQNQTHQIEQLFSELLPPLLKHALVKDVRWLGAIGVVETHTPVDMETIQAHFVEQGVWIRPFGKLIYMMPPF
ISKAEHIEQLVSSIDKALQQSACFKPS

Sequences:

>Translated_427_residues
MDLAFDRQHIWHPYTSTLTPLTCYPVTNADGVYLELEGGKRIIDGMSSWWSTIHGYNHPELNAAAHSQIDKVSHVMFGGI
THQPAIDLCKKLLNLAPNNLEHVFLADSGSVAVEVSLKMALQYWHAKGQPRSKLLTLRDGYHGDTFAAMSVTDPDNSMHS
LYKGFLPEHIFADSPKTRFWDQWDENDINSFREKLANHHQEVAAVILEPIVQGAGGMRIYHPEFLRQVRLLCDEFNVLLI
LDEIATGFGRTGKLFACEHADVKPDILCVGKALTGGYMTLSATLASKEVADTVCGGEAGCFMHGPTFMGNPLACAVGAAS
LSIIEQGHWQNQTHQIEQLFSELLPPLLKHALVKDVRWLGAIGVVETHTPVDMETIQAHFVEQGVWIRPFGKLIYMMPPF
ISKAEHIEQLVSSIDKALQQSACFKPS
>Mature_427_residues
MDLAFDRQHIWHPYTSTLTPLTCYPVTNADGVYLELEGGKRIIDGMSSWWSTIHGYNHPELNAAAHSQIDKVSHVMFGGI
THQPAIDLCKKLLNLAPNNLEHVFLADSGSVAVEVSLKMALQYWHAKGQPRSKLLTLRDGYHGDTFAAMSVTDPDNSMHS
LYKGFLPEHIFADSPKTRFWDQWDENDINSFREKLANHHQEVAAVILEPIVQGAGGMRIYHPEFLRQVRLLCDEFNVLLI
LDEIATGFGRTGKLFACEHADVKPDILCVGKALTGGYMTLSATLASKEVADTVCGGEAGCFMHGPTFMGNPLACAVGAAS
LSIIEQGHWQNQTHQIEQLFSELLPPLLKHALVKDVRWLGAIGVVETHTPVDMETIQAHFVEQGVWIRPFGKLIYMMPPF
ISKAEHIEQLVSSIDKALQQSACFKPS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=429, Percent_Identity=28.2051282051282, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=30.5295950155763, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI13994255, Length=345, Percent_Identity=28.4057971014493, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI37574042, Length=444, Percent_Identity=24.5495495495495, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=25.5102040816327, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442705, Length=365, Percent_Identity=25.7534246575342, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI24119277, Length=437, Percent_Identity=24.9427917620137, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=64.5390070921986, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI145693181, Length=397, Percent_Identity=33.2493702770781, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789016, Length=404, Percent_Identity=28.2178217821782, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=31.9201995012469, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789759, Length=324, Percent_Identity=32.4074074074074, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787560, Length=377, Percent_Identity=27.8514588859416, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=27.1662763466042, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=426, Percent_Identity=26.9953051643192, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=29.0993071593533, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=286, Percent_Identity=31.8181818181818, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=25.1748251748252, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=358, Percent_Identity=23.463687150838, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=45.9694989106754, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=28.6764705882353, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=391, Percent_Identity=27.6214833759591, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=312, Percent_Identity=27.8846153846154, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=27.0983213429257, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=26.8235294117647, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574759, Length=371, Percent_Identity=27.4932614555256, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356575, Length=324, Percent_Identity=25.3086419753086, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281366494, Length=285, Percent_Identity=25.2631578947368, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24667139, Length=285, Percent_Identity=25.2631578947368, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24667143, Length=285, Percent_Identity=25.2631578947368, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47419; Mature: 47419

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLAFDRQHIWHPYTSTLTPLTCYPVTNADGVYLELEGGKRIIDGMSSWWSTIHGYNHPE
CCCCCCCHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCC
LNAAAHSQIDKVSHVMFGGITHQPAIDLCKKLLNLAPNNLEHVFLADSGSVAVEVSLKMA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEHHHHHH
LQYWHAKGQPRSKLLTLRDGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFADSPKTRFW
HHHHHCCCCCHHHEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCCC
DQWDENDINSFREKLANHHQEVAAVILEPIVQGAGGMRIYHPEFLRQVRLLCDEFNVLLI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHCCCCEEEE
LDEIATGFGRTGKLFACEHADVKPDILCVGKALTGGYMTLSATLASKEVADTVCGGEAGC
EHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEHHHHHHHHHHHHCCCCCCE
FMHGPTFMGNPLACAVGAASLSIIEQGHWQNQTHQIEQLFSELLPPLLKHALVKDVRWLG
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGVVETHTPVDMETIQAHFVEQGVWIRPFGKLIYMMPPFISKAEHIEQLVSSIDKALQQ
CCCEEECCCCCCHHHHHHHHHHCCCEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SACFKPS
CCCCCCC
>Mature Secondary Structure
MDLAFDRQHIWHPYTSTLTPLTCYPVTNADGVYLELEGGKRIIDGMSSWWSTIHGYNHPE
CCCCCCCHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCC
LNAAAHSQIDKVSHVMFGGITHQPAIDLCKKLLNLAPNNLEHVFLADSGSVAVEVSLKMA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEHHHHHH
LQYWHAKGQPRSKLLTLRDGYHGDTFAAMSVTDPDNSMHSLYKGFLPEHIFADSPKTRFW
HHHHHCCCCCHHHEEEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCCC
DQWDENDINSFREKLANHHQEVAAVILEPIVQGAGGMRIYHPEFLRQVRLLCDEFNVLLI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHCCCCEEEE
LDEIATGFGRTGKLFACEHADVKPDILCVGKALTGGYMTLSATLASKEVADTVCGGEAGC
EHHHHHCCCCCCCEEEECCCCCCCCEEEEECHHCCCEEEEEHHHHHHHHHHHHCCCCCCE
FMHGPTFMGNPLACAVGAASLSIIEQGHWQNQTHQIEQLFSELLPPLLKHALVKDVRWLG
EEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIGVVETHTPVDMETIQAHFVEQGVWIRPFGKLIYMMPPFISKAEHIEQLVSSIDKALQQ
CCCEEECCCCCCHHHHHHHHHHCCCEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SACFKPS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]