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The map label for this gene is ribA [H]

Identifier: 218709911

GI number: 218709911

Start: 2069053

End: 2069688

Strand: Reverse

Name: ribA [H]

Synonym: VS_1924

Alternate gene names: 218709911

Gene position: 2069688-2069053 (Counterclockwise)

Preceding gene: 218709912

Following gene: 218709910

Centisome position: 62.73

GC content: 41.67

Gene sequence:

>636_bases
GTGTTGTTAAATACATCGAATTTTCAAGTGAGTATAGCTATGGCGGAAGTGCGTGCCAGAATAGATTTCAAAGTAGGGGT
AACAAGCAGTATTGATGCTGAACTTCTGTCTTTTCATGGATTGAAAACAGATAAAGAGCATGTTGCTGTGATATTTAAAT
CAGCGGATAAGACACAAGACATACCTCTTGTTCGTATGCACTCTGAGTGCCTGACTGGTGATGTTTTTCATTCTTCTCGC
TGTGACTGTGGTGAGCAGTTAGATGAAACCATCAGAATTATGGGTGAGACGGGGGGAGTGATTCTTTACTTACGCCAAGA
AGGTCGTGGTATTGGTTTGTATAACAAAATCGATGCGTACCGTCTGCAAAGCGAAGGCATGAACACCTATGAAGCGAATA
ACCACCTAGGTTTTGGTGATGATTTACGCGACTTTACCGAAGCGGCAGAAATGCTTCGCGCTTTAGGAACCACAAAAATT
CGTTTGGTTACTAACAACCCTAAGAAGATCAATGAGCTGAAATCTTTCGGTATTGAGATTGAAGAAGTGGTGAATACTTC
TGCACATATCAAGTCGGGAAATGAGAGTTACCTGAAGGCGAAAGTCTCACACGGTAAGCATAATCTGGATATTTGA

Upstream 100 bases:

>100_bases
ACAATTTGTACGTGGTCGACCTTGAAAAAAATTGTTAACAGCCTCATAGTGTCTATCATTAGATAGTTAGCTACAAAATA
TTGCCTAGACATATAGTGTA

Downstream 100 bases:

>100_bases
TAAGCTTCCTTTTATTGCTATAGCACAAAAGTATTTAAAGACCTCACAAATGTGAGGTTTTTTTGTATTTATCTTGCAAT
AAAATTGTAAGTTTGTATTA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MLLNTSNFQVSIAMAEVRARIDFKVGVTSSIDAELLSFHGLKTDKEHVAVIFKSADKTQDIPLVRMHSECLTGDVFHSSR
CDCGEQLDETIRIMGETGGVILYLRQEGRGIGLYNKIDAYRLQSEGMNTYEANNHLGFGDDLRDFTEAAEMLRALGTTKI
RLVTNNPKKINELKSFGIEIEEVVNTSAHIKSGNESYLKAKVSHGKHNLDI

Sequences:

>Translated_211_residues
MLLNTSNFQVSIAMAEVRARIDFKVGVTSSIDAELLSFHGLKTDKEHVAVIFKSADKTQDIPLVRMHSECLTGDVFHSSR
CDCGEQLDETIRIMGETGGVILYLRQEGRGIGLYNKIDAYRLQSEGMNTYEANNHLGFGDDLRDFTEAAEMLRALGTTKI
RLVTNNPKKINELKSFGIEIEEVVNTSAHIKSGNESYLKAKVSHGKHNLDI
>Mature_211_residues
MLLNTSNFQVSIAMAEVRARIDFKVGVTSSIDAELLSFHGLKTDKEHVAVIFKSADKTQDIPLVRMHSECLTGDVFHSSR
CDCGEQLDETIRIMGETGGVILYLRQEGRGIGLYNKIDAYRLQSEGMNTYEANNHLGFGDDLRDFTEAAEMLRALGTTKI
RLVTNNPKKINELKSFGIEIEEVVNTSAHIKSGNESYLKAKVSHGKHNLDI

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=185, Percent_Identity=46.4864864864865, Blast_Score=152, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=42.0118343195266, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 23490; Mature: 23490

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNTSNFQVSIAMAEVRARIDFKVGVTSSIDAELLSFHGLKTDKEHVAVIFKSADKTQD
CEECCCCCEEEEEEEEEHEEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCC
IPLVRMHSECLTGDVFHSSRCDCGEQLDETIRIMGETGGVILYLRQEGRGIGLYNKIDAY
CCEEEECHHHHCCCCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHHHHHE
RLQSEGMNTYEANNHLGFGDDLRDFTEAAEMLRALGTTKIRLVTNNPKKINELKSFGIEI
EECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCH
EEVVNTSAHIKSGNESYLKAKVSHGKHNLDI
HHHHCCHHEECCCCHHHEEEEECCCCCCCCC
>Mature Secondary Structure
MLLNTSNFQVSIAMAEVRARIDFKVGVTSSIDAELLSFHGLKTDKEHVAVIFKSADKTQD
CEECCCCCEEEEEEEEEHEEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCC
IPLVRMHSECLTGDVFHSSRCDCGEQLDETIRIMGETGGVILYLRQEGRGIGLYNKIDAY
CCEEEECHHHHCCCCCCCCCCCHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHHHHHE
RLQSEGMNTYEANNHLGFGDDLRDFTEAAEMLRALGTTKIRLVTNNPKKINELKSFGIEI
EECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCH
EEVVNTSAHIKSGNESYLKAKVSHGKHNLDI
HHHHCCHHEECCCCHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]