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The map label for this gene is sufS [H]

Identifier: 218709892

GI number: 218709892

Start: 2045780

End: 2047012

Strand: Direct

Name: sufS [H]

Synonym: VS_1905

Alternate gene names: 218709892

Gene position: 2045780-2047012 (Clockwise)

Preceding gene: 218709891

Following gene: 218709893

Centisome position: 62.01

GC content: 45.34

Gene sequence:

>1233_bases
ATGATTGATTCGAGCGAAAAGACAAGCCCTTGGTTTAACGACTTCCCAGCTCTAAGAACTCAAGTTTACGACAAGCCTTT
GGTCTATTTAGACAGTGCTGCGACGGCCCAAACCCCTCAAATCGTTATCGACCGCATGACTCAGTTTTATCAACATGATT
ATGCGAGTGTTCATCGCGGTGTCCATTACCTAAGCTCTAAAGCAACCGAAGAAATGGAACAAGTAAGAGAAAAACTTGCT
CAGTTCATTTCAGCTAAATCCCGAGAAAGTATTGTGTTCACCAAAGGGACGACAGAGGCCATCAATCTCGTTGCGAATAG
CTATTTGCGCCCTAGGTTAAAAGCGGGTGACGAAATCATCGTGACGGAAATGGAGCATCACGCCAACCTTGTTCCTTGGC
AGATGCTTTCTGAAATTTATAATGTCAACATTCGTGTTTGGCCAATGGCAAAAAATGGCTATTTGAATCTCAACGACCTT
GTCTCGTTAATGAATACAAAGACAAAACTGCTGGCGATTAGCCACGTATCGAATGTTCTAGGCCGCGTAAACCCAATTAA
AACGATAGTCAAAGCTGCGCATAAAGCAAAAGTCCCCGTGTTAGTCGACGGTGCTCAAGCTGTCATGCACGATGAAGTCA
ATGTGACGCACCTCGATTGTGATTTCTACGCCTTCTCTGGGCACAAATTGTATGGCCCGACAGGCATCGGCGTGCTTTAT
GCAAAAAAAACACACCTCGACAACATGGTGCCATGGGAAGGCGGCGGAGCCATGATCGATCAAGTTACACTGCCTTTGGG
AACCTCGTTTGGCCAAGCTCCGTGGAAGTTCGAAGCGGGCACTCCGAATATTGCAGGCATTTTAGGTTTAGGCGCCGCTC
TAGACTACATAGAAGCTATCGGCTTCAAAGAGATCTCTGACTATGAAAAAAATGTAATGAATTATTTGGTGGAGAGCATT
AGACAGATACCAGCAATAGAGGTCTATGGCGATGATGATAACCGCACGGGCGTTTTGGCTTTTAATATGAAAAATCAACA
CTCTTTTGATGTGGGTTCATTCTTAGATAGATATGGTATTGCGATTCGTACCGGGCATCTCTGTGCAATGCCCCTTATAA
AACGACTCGGTCAAAACTCGCTGTGTCGCGCATCGATTGGCATATACACAAGGCCCAAAGACATAGACGCCTTGTGCCAG
TCACTAAAACGAATCCACCAACTGTTAAGGTAG

Upstream 100 bases:

>100_bases
TCTGCGTTTGTCATTGACGTTACCGATAGAATTAAACACCCCGCCCTAAGACAATCTGCGATAGATAAAATCAATGCGTC
ACTCAATAAAGGATGTCCTA

Downstream 100 bases:

>100_bases
CTTATGTCCCCTGAAAAGCTCCAGAAAAACTTCGAGCGATGCGCTGACTGGGAAGAACGTTATATGTATTTGATAGAATT
GGGGGACCGATTAGAGCCCT

Product: cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MIDSSEKTSPWFNDFPALRTQVYDKPLVYLDSAATAQTPQIVIDRMTQFYQHDYASVHRGVHYLSSKATEEMEQVREKLA
QFISAKSRESIVFTKGTTEAINLVANSYLRPRLKAGDEIIVTEMEHHANLVPWQMLSEIYNVNIRVWPMAKNGYLNLNDL
VSLMNTKTKLLAISHVSNVLGRVNPIKTIVKAAHKAKVPVLVDGAQAVMHDEVNVTHLDCDFYAFSGHKLYGPTGIGVLY
AKKTHLDNMVPWEGGGAMIDQVTLPLGTSFGQAPWKFEAGTPNIAGILGLGAALDYIEAIGFKEISDYEKNVMNYLVESI
RQIPAIEVYGDDDNRTGVLAFNMKNQHSFDVGSFLDRYGIAIRTGHLCAMPLIKRLGQNSLCRASIGIYTRPKDIDALCQ
SLKRIHQLLR

Sequences:

>Translated_410_residues
MIDSSEKTSPWFNDFPALRTQVYDKPLVYLDSAATAQTPQIVIDRMTQFYQHDYASVHRGVHYLSSKATEEMEQVREKLA
QFISAKSRESIVFTKGTTEAINLVANSYLRPRLKAGDEIIVTEMEHHANLVPWQMLSEIYNVNIRVWPMAKNGYLNLNDL
VSLMNTKTKLLAISHVSNVLGRVNPIKTIVKAAHKAKVPVLVDGAQAVMHDEVNVTHLDCDFYAFSGHKLYGPTGIGVLY
AKKTHLDNMVPWEGGGAMIDQVTLPLGTSFGQAPWKFEAGTPNIAGILGLGAALDYIEAIGFKEISDYEKNVMNYLVESI
RQIPAIEVYGDDDNRTGVLAFNMKNQHSFDVGSFLDRYGIAIRTGHLCAMPLIKRLGQNSLCRASIGIYTRPKDIDALCQ
SLKRIHQLLR
>Mature_410_residues
MIDSSEKTSPWFNDFPALRTQVYDKPLVYLDSAATAQTPQIVIDRMTQFYQHDYASVHRGVHYLSSKATEEMEQVREKLA
QFISAKSRESIVFTKGTTEAINLVANSYLRPRLKAGDEIIVTEMEHHANLVPWQMLSEIYNVNIRVWPMAKNGYLNLNDL
VSLMNTKTKLLAISHVSNVLGRVNPIKTIVKAAHKAKVPVLVDGAQAVMHDEVNVTHLDCDFYAFSGHKLYGPTGIGVLY
AKKTHLDNMVPWEGGGAMIDQVTLPLGTSFGQAPWKFEAGTPNIAGILGLGAALDYIEAIGFKEISDYEKNVMNYLVESI
RQIPAIEVYGDDDNRTGVLAFNMKNQHSFDVGSFLDRYGIAIRTGHLCAMPLIKRLGQNSLCRASIGIYTRPKDIDALCQ
SLKRIHQLLR

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=310, Percent_Identity=27.4193548387097, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI156713448, Length=324, Percent_Identity=28.3950617283951, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=55.0505050505051, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789175, Length=395, Percent_Identity=41.0126582278481, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=26.6832917705736, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=252, Percent_Identity=30.952380952381, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=410, Percent_Identity=24.390243902439, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17533177, Length=341, Percent_Identity=26.099706744868, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319831, Length=252, Percent_Identity=31.3492063492063, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI20129463, Length=296, Percent_Identity=29.0540540540541, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45799; Mature: 45799

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSSEKTSPWFNDFPALRTQVYDKPLVYLDSAATAQTPQIVIDRMTQFYQHDYASVHRG
CCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VHYLSSKATEEMEQVREKLAQFISAKSRESIVFTKGTTEAINLVANSYLRPRLKAGDEII
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCEEE
VTEMEHHANLVPWQMLSEIYNVNIRVWPMAKNGYLNLNDLVSLMNTKTKLLAISHVSNVL
EEEHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHH
GRVNPIKTIVKAAHKAKVPVLVDGAQAVMHDEVNVTHLDCDFYAFSGHKLYGPTGIGVLY
HCCCHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEECEEEEECCCEEECCCCCEEEE
AKKTHLDNMVPWEGGGAMIDQVTLPLGTSFGQAPWKFEAGTPNIAGILGLGAALDYIEAI
EEHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHC
GFKEISDYEKNVMNYLVESIRQIPAIEVYGDDDNRTGVLAFNMKNQHSFDVGSFLDRYGI
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHCCC
AIRTGHLCAMPLIKRLGQNSLCRASIGIYTRPKDIDALCQSLKRIHQLLR
EEECCCCHHHHHHHHCCCCCCEEHHCCCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIDSSEKTSPWFNDFPALRTQVYDKPLVYLDSAATAQTPQIVIDRMTQFYQHDYASVHRG
CCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VHYLSSKATEEMEQVREKLAQFISAKSRESIVFTKGTTEAINLVANSYLRPRLKAGDEII
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHCCCCEEE
VTEMEHHANLVPWQMLSEIYNVNIRVWPMAKNGYLNLNDLVSLMNTKTKLLAISHVSNVL
EEEHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHH
GRVNPIKTIVKAAHKAKVPVLVDGAQAVMHDEVNVTHLDCDFYAFSGHKLYGPTGIGVLY
HCCCHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEECEEEEECCCEEECCCCCEEEE
AKKTHLDNMVPWEGGGAMIDQVTLPLGTSFGQAPWKFEAGTPNIAGILGLGAALDYIEAI
EEHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHC
GFKEISDYEKNVMNYLVESIRQIPAIEVYGDDDNRTGVLAFNMKNQHSFDVGSFLDRYGI
CCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHCCC
AIRTGHLCAMPLIKRLGQNSLCRASIGIYTRPKDIDALCQSLKRIHQLLR
EEECCCCHHHHHHHHCCCCCCEEHHCCCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA