Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 218709832

GI number: 218709832

Start: 1991612

End: 1992817

Strand: Reverse

Name: nhaA [H]

Synonym: VS_1845

Alternate gene names: 218709832

Gene position: 1992817-1991612 (Counterclockwise)

Preceding gene: 218709833

Following gene: 218709829

Centisome position: 60.4

GC content: 44.2

Gene sequence:

>1206_bases
TTGTTATTCGTTTATTTAAATAATAAATATAAGGGCGAAATCATGACCGACGTCATCCGTGACTTCTTTAAATTGGAATC
TGCTGGCGGCATCATACTAGTCATCGCTGCGGCGATCGCAATGTTTGTAGCAAACTCACCATTGAACGAAATGTACCAAG
GGGTACTGCACAGCTATGTTCTTGGTATGTCTGTATCACACTGGATTAACGATGGCTTAATGGCTGTCTTCTTCCTTCTA
ATTGGCTTAGAAGTTAAGCGCGAACTGTTAGAAGGCGCATTAAAGTCTAAAGAGACAGCAATCTTCCCAGCTATCGCAGC
GGTGGGTGGTATGCTAGCTCCTGCACTTATTTACGTGCTATTCAATTCAAGTAACCCTGAAGCGCTTCAAGGTTGGGCTA
TCCCAGCGGCAACTGATATTGCTTTCGCATTGGGCATCATGGCTCTTCTTGGTAACCGTGTACCGGTAAGCTTGAAGGTA
TTCCTACTAGCGTTGGCAATTATCGATGATCTAGGGGTTGTTGTTATCATTGCACTGTTCTACTCAGGTGATCTATCGAC
GCTTGCACTAACGGTTGGCTTCATTGCAACTGGTGTGCTGTTCATGCTAAACAACAAGCATGTAACTAAGCTGAGTGTTT
ACCTTATTGTTGGTGCAATTCTGTGGTTCGCAGTATTGAAGTCAGGTGTTCACGCAACATTGGCTGGTGTAGTCATTGGT
TTTGCTATCCCACTGAAAGGCAATAAAGGAGAGCGTTCTCCGCTGAAACATCTAGAACATGCTCTGCACCCATACGTCGC
TTTTGCAATTTTGCCAATCTTCGCATTTGCAAACGCAGGTATCTCACTAGAAGGCATCTCAATTTCAAACCTTACAGGCA
TGCTACCTCTTGGTATTGCTATGGGTCTATTGGTTGGTAAGCCTCTGGGTATCTTCCTATTCAGCTGGGGTGCTGTGAAA
ACGGGCATCGCTAAGCTTCCTGAAGGTGTGAACTTCATGAACATCTTCGCGGTATCTGTGTTGTGTGGTATTGGCTTTAC
GATGTCTATCTTTATTTCATCGCTAGCATTTGGTCCAACGAACGCAGATTTTGATACGCTTGCTCGATTAGGTATCCTGA
TGGGCTCAACGACCGCAGCTATCTTAGGTTACTTCCTGCTAAGTATTTCTCTACCGAAAACTAAGCATCAAGAAGTAAAG
CTATAA

Upstream 100 bases:

>100_bases
TACGACGTATTGTTTAGTATTTGTAGGAAAAACCGAAGTTAAACATCCGAAGAAGTGATTATCTATCGATAGAGCTTGGA
TATAAACTCGTGGTTATTCT

Downstream 100 bases:

>100_bases
TTGGCAGGTAAAAGCATAATCGGTAGTAGGTTCGCTTAAGAGGGAGCCTACTCACTGAGTAACAAGTCAATTTCTGAGTA
GCAAGAAGAGTCACAGAATC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLFVYLNNKYKGEIMTDVIRDFFKLESAGGIILVIAAAIAMFVANSPLNEMYQGVLHSYVLGMSVSHWINDGLMAVFFLL
IGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALIYVLFNSSNPEALQGWAIPAATDIAFALGIMALLGNRVPVSLKV
FLLALAIIDDLGVVVIIALFYSGDLSTLALTVGFIATGVLFMLNNKHVTKLSVYLIVGAILWFAVLKSGVHATLAGVVIG
FAIPLKGNKGERSPLKHLEHALHPYVAFAILPIFAFANAGISLEGISISNLTGMLPLGIAMGLLVGKPLGIFLFSWGAVK
TGIAKLPEGVNFMNIFAVSVLCGIGFTMSIFISSLAFGPTNADFDTLARLGILMGSTTAAILGYFLLSISLPKTKHQEVK
L

Sequences:

>Translated_401_residues
MLFVYLNNKYKGEIMTDVIRDFFKLESAGGIILVIAAAIAMFVANSPLNEMYQGVLHSYVLGMSVSHWINDGLMAVFFLL
IGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALIYVLFNSSNPEALQGWAIPAATDIAFALGIMALLGNRVPVSLKV
FLLALAIIDDLGVVVIIALFYSGDLSTLALTVGFIATGVLFMLNNKHVTKLSVYLIVGAILWFAVLKSGVHATLAGVVIG
FAIPLKGNKGERSPLKHLEHALHPYVAFAILPIFAFANAGISLEGISISNLTGMLPLGIAMGLLVGKPLGIFLFSWGAVK
TGIAKLPEGVNFMNIFAVSVLCGIGFTMSIFISSLAFGPTNADFDTLARLGILMGSTTAAILGYFLLSISLPKTKHQEVK
L
>Mature_401_residues
MLFVYLNNKYKGEIMTDVIRDFFKLESAGGIILVIAAAIAMFVANSPLNEMYQGVLHSYVLGMSVSHWINDGLMAVFFLL
IGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALIYVLFNSSNPEALQGWAIPAATDIAFALGIMALLGNRVPVSLKV
FLLALAIIDDLGVVVIIALFYSGDLSTLALTVGFIATGVLFMLNNKHVTKLSVYLIVGAILWFAVLKSGVHATLAGVVIG
FAIPLKGNKGERSPLKHLEHALHPYVAFAILPIFAFANAGISLEGISISNLTGMLPLGIAMGLLVGKPLGIFLFSWGAVK
TGIAKLPEGVNFMNIFAVSVLCGIGFTMSIFISSLAFGPTNADFDTLARLGILMGSTTAAILGYFLLSISLPKTKHQEVK
L

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=324, Percent_Identity=61.1111111111111, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42604; Mature: 42604

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFVYLNNKYKGEIMTDVIRDFFKLESAGGIILVIAAAIAMFVANSPLNEMYQGVLHSYV
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALIYVL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FNSSNPEALQGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIALF
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YSGDLSTLALTVGFIATGVLFMLNNKHVTKLSVYLIVGAILWFAVLKSGVHATLAGVVIG
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FAIPLKGNKGERSPLKHLEHALHPYVAFAILPIFAFANAGISLEGISISNLTGMLPLGIA
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCHHHHHHHHHH
MGLLVGKPLGIFLFSWGAVKTGIAKLPEGVNFMNIFAVSVLCGIGFTMSIFISSLAFGPT
HHHHHCCCHHHHHEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
NADFDTLARLGILMGSTTAAILGYFLLSISLPKTKHQEVKL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLFVYLNNKYKGEIMTDVIRDFFKLESAGGIILVIAAAIAMFVANSPLNEMYQGVLHSYV
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALIYVL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FNSSNPEALQGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIALF
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YSGDLSTLALTVGFIATGVLFMLNNKHVTKLSVYLIVGAILWFAVLKSGVHATLAGVVIG
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FAIPLKGNKGERSPLKHLEHALHPYVAFAILPIFAFANAGISLEGISISNLTGMLPLGIA
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHCHHHHHHHHHH
MGLLVGKPLGIFLFSWGAVKTGIAKLPEGVNFMNIFAVSVLCGIGFTMSIFISSLAFGPT
HHHHHCCCHHHHHEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
NADFDTLARLGILMGSTTAAILGYFLLSISLPKTKHQEVKL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA