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The map label for this gene is fadE [H]

Identifier: 218709827

GI number: 218709827

Start: 1981938

End: 1984220

Strand: Reverse

Name: fadE [H]

Synonym: VS_1840

Alternate gene names: 218709827

Gene position: 1984220-1981938 (Counterclockwise)

Preceding gene: 218709828

Following gene: 218709826

Centisome position: 60.14

GC content: 47.0

Gene sequence:

>2283_bases
ATGAGCTCTCTAAGACAAAAATGGGTAAGTGACCCAGCTTTTAAACTCTTTAAAAAAGTACTACCACCCCTATCTAGCAC
CGAGAAAGAAGCGATGGAAGCGGGTAGCGTGTGGTGGGACGGAGAGCTGTTTTCTGGTAAACCAGATTTCACTAAGCTTC
ACCAGTACCCAAAACCTCAGCTGACAGCAGAAGAGCAATCGTTCATGGACAATGAACTTGAAACTTTGCTCGCTATGCTC
GATGACCACAAAATTGTGAAAGAAGACCGAGACCTTCCTGAGGAAGTATGGAACTTTTTACGCAAAGAGCGTTTCTTCTC
GCTAATTATCGCGAAAGGGTACGGCGGCCGTGAATTTTCGGCGCACGCCAACTCTACAATCGTAACTAAGATTGCAACGC
GTAGTATCAGTACCGCGGTTTCGGTAATGGTTCCAAACTCTCTTGGCCCTGGTGAGCTGCTGTCTCACTACGGTACTCAA
GATCAAAAAGATTACTGGCTACCTCGTCTTGCTGACGGTACAGACATCCCTTGTTTCGCACTAACAGGACCTGAAGCAGG
TTCTGATGCGGGTGGTATCCCTGATGTCGGTACAGTGTGTATGGGCATGCACGAAGGTAAAGAGACACTAGGCATCAAGC
TTAACTGGAACAAGCGTTACATTACGCTAGCACCAGTGGCAACGGTACTTGGTTTGGCTTTCAAATTGCACGATCCAGAA
AAGCTACTGGGTGACAAAGAAGACATTGGTATCACTTGTGCGCTTATCCCGGCAGACCACGAAGGTGTTGTGATTGGTGA
GCGTCATGATCCACTTGGTCTTGCGTTTATGAATGGTCCAACACGCGGTCACGATGTATTTATTCCTATGGAATGGCTAA
TCGGTGGCGCAGATTACGCAGGTAAAGGCTGGCGTATGCTGGTGGAATGTTTGTCTGCAGGTCGTGGTATCTCATTACCC
GCACTTGGTACGGCGATGGGCCACCTAACAGCGAAAACGACCGGCGCATACGCTTATGTTCGTAAGCAGTTCGGTATGTC
GATTGGTAAATTTGAAGGTGTTGCAGAGAGCTTAGGCCGTATTGGTGGTTTAACGTATCTATTAGAAGCGACTCGTACAC
TGACAACCACTTCACTTGATATGAAAGAGAAGCCGGGTATCGTAACGGCTATCGCGAAGTATCACATGACAGAGATGGCT
CGTACTATTCTGAATGACTCAATGGATATCCATTCAGGTCGTGCAATTCAAGATGGCCCAATGAACTACTTGGCTGCGCC
TTACCTAGGTATTCCAGTTGCTATCACAGTAGAAGGTGCGAACATTCTAACTCGTAACCTGATGATCTTCGGTCAAGGTG
CGACACGTTGTCACCCATACGTATTGAGCGAAATGGAAGCGGCAGCGAATCCAGACGAGAAGCAAGGTGCAAAAGACTTT
GATAGCTTGTTGTTCAAGCACATCTCACACGCAACTAAAAACACGTTTGGTGCGTTTGGCGCAGCACTAACTGGCTCTAA
GTTCATTAAAGCCGACATGAGCGGTCCAACGAAGCCTTACTACCAAGATTTGACTCGTTTGAGCCGCGCACTTGCAGTGA
GTGCGGATTTCGCAATGCTGACGCTAGGTGGTGAACTGAAACGTAAAGAGCTTATCTCTGCACGTTTGGGTGATGGTCTA
AGTTACCTATACATGGCGTCTGCTGCACTTAAAAAGTATGAAGACGAAGGTCGTCAACAAGCTGACCTAGACTACGTACA
CTACGCGGTTCAACACTGTTTCCACAATGCGGCTAAGTCGTTACAAGAAGCGTACCGTAACTTCCCGAACAAGATGGTTG
GAAAAGTACTTAAAGGTCTAGTTTTCCCTGTAGGTAACCACTTCGAAAAACCAAGTGATAACCTAACAGTTCAACTAGCA
GAAAGCTTGATGACTCCGGGAGCACACCGTGAACGTCTGACTCACCTTTGCTACATCGGCAAGGAAGAGGATGATAGTGT
TGGCCTTATGGAGAACGCGTTCAATGCGATGTACAGCATCAAGCCTCTGGAGCGTAAGATCTTTAAAGCAGTGAAAGAGG
GCAAAGTGGCTCGTAAAGGCTTGTTGGCAGACAAACTGGCTCAAGCACTTGCTGCCGATGTTCTGACACAAGAAGAAGTC
GACCAAATTGTTGCTGCTGATAAACTACGTTACACAGCGATTCAAGTTGACCACTTCAGTCATGACTTTAGTGAAACTTT
GACGCGAAAAGAGTTAAAACCTAAGCTAAATAGCGTTGCTTAG

Upstream 100 bases:

>100_bases
ATTCTCATTCCATTTTTGGCCGCTGGCATGTCAGCAAAAGAATAAAACAATAAAAAGCAAAATATTCACAAACAATATAG
TGAACAAAAGGATCTGAACT

Downstream 100 bases:

>100_bases
ATAACGAAATGATAAAAGGCACCTAATAAGGTGCCTTTTTTGTTTTTGTCGTAGAAGTCGCAATAGAAGCGTTAACAAAT
GGTGACTTAGTCGGCAAATA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MSSLRQKWVSDPAFKLFKKVLPPLSSTEKEAMEAGSVWWDGELFSGKPDFTKLHQYPKPQLTAEEQSFMDNELETLLAML
DDHKIVKEDRDLPEEVWNFLRKERFFSLIIAKGYGGREFSAHANSTIVTKIATRSISTAVSVMVPNSLGPGELLSHYGTQ
DQKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDVGTVCMGMHEGKETLGIKLNWNKRYITLAPVATVLGLAFKLHDPE
KLLGDKEDIGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMEWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAMGHLTAKTTGAYAYVRKQFGMSIGKFEGVAESLGRIGGLTYLLEATRTLTTTSLDMKEKPGIVTAIAKYHMTEMA
RTILNDSMDIHSGRAIQDGPMNYLAAPYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLSEMEAAANPDEKQGAKDF
DSLLFKHISHATKNTFGAFGAALTGSKFIKADMSGPTKPYYQDLTRLSRALAVSADFAMLTLGGELKRKELISARLGDGL
SYLYMASAALKKYEDEGRQQADLDYVHYAVQHCFHNAAKSLQEAYRNFPNKMVGKVLKGLVFPVGNHFEKPSDNLTVQLA
ESLMTPGAHRERLTHLCYIGKEEDDSVGLMENAFNAMYSIKPLERKIFKAVKEGKVARKGLLADKLAQALAADVLTQEEV
DQIVAADKLRYTAIQVDHFSHDFSETLTRKELKPKLNSVA

Sequences:

>Translated_760_residues
MSSLRQKWVSDPAFKLFKKVLPPLSSTEKEAMEAGSVWWDGELFSGKPDFTKLHQYPKPQLTAEEQSFMDNELETLLAML
DDHKIVKEDRDLPEEVWNFLRKERFFSLIIAKGYGGREFSAHANSTIVTKIATRSISTAVSVMVPNSLGPGELLSHYGTQ
DQKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDVGTVCMGMHEGKETLGIKLNWNKRYITLAPVATVLGLAFKLHDPE
KLLGDKEDIGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMEWLIGGADYAGKGWRMLVECLSAGRGISLP
ALGTAMGHLTAKTTGAYAYVRKQFGMSIGKFEGVAESLGRIGGLTYLLEATRTLTTTSLDMKEKPGIVTAIAKYHMTEMA
RTILNDSMDIHSGRAIQDGPMNYLAAPYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLSEMEAAANPDEKQGAKDF
DSLLFKHISHATKNTFGAFGAALTGSKFIKADMSGPTKPYYQDLTRLSRALAVSADFAMLTLGGELKRKELISARLGDGL
SYLYMASAALKKYEDEGRQQADLDYVHYAVQHCFHNAAKSLQEAYRNFPNKMVGKVLKGLVFPVGNHFEKPSDNLTVQLA
ESLMTPGAHRERLTHLCYIGKEEDDSVGLMENAFNAMYSIKPLERKIFKAVKEGKVARKGLLADKLAQALAADVLTQEEV
DQIVAADKLRYTAIQVDHFSHDFSETLTRKELKPKLNSVA
>Mature_759_residues
SSLRQKWVSDPAFKLFKKVLPPLSSTEKEAMEAGSVWWDGELFSGKPDFTKLHQYPKPQLTAEEQSFMDNELETLLAMLD
DHKIVKEDRDLPEEVWNFLRKERFFSLIIAKGYGGREFSAHANSTIVTKIATRSISTAVSVMVPNSLGPGELLSHYGTQD
QKDYWLPRLADGTDIPCFALTGPEAGSDAGGIPDVGTVCMGMHEGKETLGIKLNWNKRYITLAPVATVLGLAFKLHDPEK
LLGDKEDIGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMEWLIGGADYAGKGWRMLVECLSAGRGISLPA
LGTAMGHLTAKTTGAYAYVRKQFGMSIGKFEGVAESLGRIGGLTYLLEATRTLTTTSLDMKEKPGIVTAIAKYHMTEMAR
TILNDSMDIHSGRAIQDGPMNYLAAPYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLSEMEAAANPDEKQGAKDFD
SLLFKHISHATKNTFGAFGAALTGSKFIKADMSGPTKPYYQDLTRLSRALAVSADFAMLTLGGELKRKELISARLGDGLS
YLYMASAALKKYEDEGRQQADLDYVHYAVQHCFHNAAKSLQEAYRNFPNKMVGKVLKGLVFPVGNHFEKPSDNLTVQLAE
SLMTPGAHRERLTHLCYIGKEEDDSVGLMENAFNAMYSIKPLERKIFKAVKEGKVARKGLLADKLAQALAADVLTQEEVD
QIVAADKLRYTAIQVDHFSHDFSETLTRKELKPKLNSVA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=381, Percent_Identity=27.2965879265092, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557233, Length=307, Percent_Identity=29.3159609120521, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4557235, Length=408, Percent_Identity=24.7549019607843, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=24.8041775456919, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI4501859, Length=360, Percent_Identity=27.2222222222222, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI87081702, Length=753, Percent_Identity=51.394422310757, Blast_Score=778, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=358, Percent_Identity=29.0502793296089, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=26.4397905759162, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=347, Percent_Identity=26.2247838616715, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281363737, Length=520, Percent_Identity=22.6923076923077, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21356377, Length=356, Percent_Identity=27.5280898876405, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666513, Length=293, Percent_Identity=28.6689419795222, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83478; Mature: 83347

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLRQKWVSDPAFKLFKKVLPPLSSTEKEAMEAGSVWWDGELFSGKPDFTKLHQYPKPQ
CCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCEEECCEECCCCCCHHHHHCCCCCC
LTAEEQSFMDNELETLLAMLDDHKIVKEDRDLPEEVWNFLRKERFFSLIIAKGYGGREFS
CCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEC
AHANSTIVTKIATRSISTAVSVMVPNSLGPGELLSHYGTQDQKDYWLPRLADGTDIPCFA
CCCCCEEEEHHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGGIPDVGTVCMGMHEGKETLGIKLNWNKRYITLAPVATVLGLAFKLHDPE
ECCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCCHH
KLLGDKEDIGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMEWLIGGADYA
HHCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAMGHLTAKTTGAYAYVRKQFGMSIGKFEGVAESLGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDMKEKPGIVTAIAKYHMTEMARTILNDSMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MNYLAAPYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLSEMEAAANPDEKQGAKDF
CHHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCHHHH
DSLLFKHISHATKNTFGAFGAALTGSKFIKADMSGPTKPYYQDLTRLSRALAVSADFAML
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEE
TLGGELKRKELISARLGDGLSYLYMASAALKKYEDEGRQQADLDYVHYAVQHCFHNAAKS
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHH
LQEAYRNFPNKMVGKVLKGLVFPVGNHFEKPSDNLTVQLAESLMTPGAHRERLTHLCYIG
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEC
KEEDDSVGLMENAFNAMYSIKPLERKIFKAVKEGKVARKGLLADKLAQALAADVLTQEEV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQIVAADKLRYTAIQVDHFSHDFSETLTRKELKPKLNSVA
HHHHHHHHHEEEEEEEEHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLRQKWVSDPAFKLFKKVLPPLSSTEKEAMEAGSVWWDGELFSGKPDFTKLHQYPKPQ
CHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCEEECCEECCCCCCHHHHHCCCCCC
LTAEEQSFMDNELETLLAMLDDHKIVKEDRDLPEEVWNFLRKERFFSLIIAKGYGGREFS
CCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEC
AHANSTIVTKIATRSISTAVSVMVPNSLGPGELLSHYGTQDQKDYWLPRLADGTDIPCFA
CCCCCEEEEHHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTGPEAGSDAGGIPDVGTVCMGMHEGKETLGIKLNWNKRYITLAPVATVLGLAFKLHDPE
ECCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCCHH
KLLGDKEDIGITCALIPADHEGVVIGERHDPLGLAFMNGPTRGHDVFIPMEWLIGGADYA
HHCCCCCCCCEEEEEEECCCCCEEEECCCCCCEEEEECCCCCCCEEEEEHHHHCCCCCCC
GKGWRMLVECLSAGRGISLPALGTAMGHLTAKTTGAYAYVRKQFGMSIGKFEGVAESLGR
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHH
IGGLTYLLEATRTLTTTSLDMKEKPGIVTAIAKYHMTEMARTILNDSMDIHSGRAIQDGP
HHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MNYLAAPYLGIPVAITVEGANILTRNLMIFGQGATRCHPYVLSEMEAAANPDEKQGAKDF
CHHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCHHCCHHHH
DSLLFKHISHATKNTFGAFGAALTGSKFIKADMSGPTKPYYQDLTRLSRALAVSADFAML
HHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEE
TLGGELKRKELISARLGDGLSYLYMASAALKKYEDEGRQQADLDYVHYAVQHCFHNAAKS
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHH
LQEAYRNFPNKMVGKVLKGLVFPVGNHFEKPSDNLTVQLAESLMTPGAHRERLTHLCYIG
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEC
KEEDDSVGLMENAFNAMYSIKPLERKIFKAVKEGKVARKGLLADKLAQALAADVLTQEEV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
DQIVAADKLRYTAIQVDHFSHDFSETLTRKELKPKLNSVA
HHHHHHHHHEEEEEEEEHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]