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The map label for this gene is tyrP [H]

Identifier: 218709793

GI number: 218709793

Start: 1934885

End: 1936039

Strand: Reverse

Name: tyrP [H]

Synonym: VS_1805

Alternate gene names: 218709793

Gene position: 1936039-1934885 (Counterclockwise)

Preceding gene: 218709794

Following gene: 218709789

Centisome position: 58.68

GC content: 45.97

Gene sequence:

>1155_bases
ATGAATATTAAAATGATGGGTAGCTCCCTAATTATCGCTGGTACCGCTCTCGGTGCTGGTATGCTTGCGATCCCAATGGT
ATTAGCTCAATTCGGATTGCTTTACGGCACACTGCTTATGGTACTGATCTGCTTCGGTACGACTTATGCAGCATTACTAC
TTCTAGAAGCGACCATCAAAGCGGGTGGCGGTCTAGGATTAAACTCTATTGCCCGAAAAACCTTGGGCAAACAAGGGCAG
TTGATTACCAACGGCCTACTTTACGCGTTATTGATTTGCCTATTGATGGCCTACATTCTGGGTGCGGGTGATTTGCTGAG
TAAGTTACTGTCTAACTTAGGTGTAGACATTAGCGCAACGACGAGCCAAATCACGTTTACTTTACTTGCTGGTGCTGTAG
TCGCAAGTGGCACCGGAGTGATTGATAAGCTCAACCGCGCATTGTTCTTTGTGATGCTAGCAAGCTTGTTTGCAACCATG
GTGTTTTTGGCACCAAGTATGACGCAAGAAAACTTGATGCAGGTAACCAGCCACGACCACGTCGATCTAATCAAAACCAG
TGCCATCCTGTTTACGAGCTTTGGCTTTATGGTTGTGATTCCAACCTTGGTTTCTTACAACCACGAAGCGACAGACAAAC
AGCTGCGTAACATGGTTATTATCGGTTCTCTGATTCCATTAGTGTGCTACTTGTGCTGGTTGTTTGCTGTGGTTGGTAAC
TTGAGTGAAGAGCAATTCAGAAGCTTTGAGAACGTATCAGATTTGATGGCGGCGTTTGAGGCTCAGTCTCCTTGGGTGGG
TAACGTTCTGTCTACCTTCACGGGCTTGGCGTTGTTGACCTCTTTCTTTGGTGTGGCGATGGCGTTGTTCAACCAGAACA
AAGATATGTTCAACCAAAATACAGCGGTAACGTACTGCATTAGCTTTATCTTGCCGTTAGCGGGTTCATTGCTTGCTGCA
GACAAGTTCCTACAAGTGCTGAATTACGCAGGTATCATCTTGGTGTTCCTAGCGGTGTTTGTTCCTCTGGTGATGGTTCA
CAAGCAGCGCTTCATGAAAGTTGCTGATGATAGATACCGAGCAGAAGGTGGCAGCGCAATGATGCTTTTCTCATTGTTGT
TTGGTTGCTTCTTGCTTATCTCACAAGTGATCTAG

Upstream 100 bases:

>100_bases
TTATTCGTTTTATAACTTTATTTCTATCTGAACTCCTTTGTCATCCGCTCGATGAACGAAGACTCACATCTATAAAAACT
AAACAAATAAGTTAAAAACA

Downstream 100 bases:

>100_bases
TTCTTTGGTCCATTATCTACGGTGCGAATCGAGCATCTTAGATATAAGTGACCGGAATTCAGATACAAAAAAAGGAACGC
ATCGGCGTTCCTTTTTATTA

Product: Tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNIKMMGSSLIIAGTALGAGMLAIPMVLAQFGLLYGTLLMVLICFGTTYAALLLLEATIKAGGGLGLNSIARKTLGKQGQ
LITNGLLYALLICLLMAYILGAGDLLSKLLSNLGVDISATTSQITFTLLAGAVVASGTGVIDKLNRALFFVMLASLFATM
VFLAPSMTQENLMQVTSHDHVDLIKTSAILFTSFGFMVVIPTLVSYNHEATDKQLRNMVIIGSLIPLVCYLCWLFAVVGN
LSEEQFRSFENVSDLMAAFEAQSPWVGNVLSTFTGLALLTSFFGVAMALFNQNKDMFNQNTAVTYCISFILPLAGSLLAA
DKFLQVLNYAGIILVFLAVFVPLVMVHKQRFMKVADDRYRAEGGSAMMLFSLLFGCFLLISQVI

Sequences:

>Translated_384_residues
MNIKMMGSSLIIAGTALGAGMLAIPMVLAQFGLLYGTLLMVLICFGTTYAALLLLEATIKAGGGLGLNSIARKTLGKQGQ
LITNGLLYALLICLLMAYILGAGDLLSKLLSNLGVDISATTSQITFTLLAGAVVASGTGVIDKLNRALFFVMLASLFATM
VFLAPSMTQENLMQVTSHDHVDLIKTSAILFTSFGFMVVIPTLVSYNHEATDKQLRNMVIIGSLIPLVCYLCWLFAVVGN
LSEEQFRSFENVSDLMAAFEAQSPWVGNVLSTFTGLALLTSFFGVAMALFNQNKDMFNQNTAVTYCISFILPLAGSLLAA
DKFLQVLNYAGIILVFLAVFVPLVMVHKQRFMKVADDRYRAEGGSAMMLFSLLFGCFLLISQVI
>Mature_384_residues
MNIKMMGSSLIIAGTALGAGMLAIPMVLAQFGLLYGTLLMVLICFGTTYAALLLLEATIKAGGGLGLNSIARKTLGKQGQ
LITNGLLYALLICLLMAYILGAGDLLSKLLSNLGVDISATTSQITFTLLAGAVVASGTGVIDKLNRALFFVMLASLFATM
VFLAPSMTQENLMQVTSHDHVDLIKTSAILFTSFGFMVVIPTLVSYNHEATDKQLRNMVIIGSLIPLVCYLCWLFAVVGN
LSEEQFRSFENVSDLMAAFEAQSPWVGNVLSTFTGLALLTSFFGVAMALFNQNKDMFNQNTAVTYCISFILPLAGSLLAA
DKFLQVLNYAGIILVFLAVFVPLVMVHKQRFMKVADDRYRAEGGSAMMLFSLLFGCFLLISQVI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=387, Percent_Identity=35.1421188630491, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1790145, Length=383, Percent_Identity=27.4151436031332, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789552, Length=370, Percent_Identity=25.1351351351351, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 41357; Mature: 41357

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKMMGSSLIIAGTALGAGMLAIPMVLAQFGLLYGTLLMVLICFGTTYAALLLLEATIK
CCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGGLGLNSIARKTLGKQGQLITNGLLYALLICLLMAYILGAGDLLSKLLSNLGVDISAT
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TSQITFTLLAGAVVASGTGVIDKLNRALFFVMLASLFATMVFLAPSMTQENLMQVTSHDH
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
VDLIKTSAILFTSFGFMVVIPTLVSYNHEATDKQLRNMVIIGSLIPLVCYLCWLFAVVGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSEEQFRSFENVSDLMAAFEAQSPWVGNVLSTFTGLALLTSFFGVAMALFNQNKDMFNQN
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TAVTYCISFILPLAGSLLAADKFLQVLNYAGIILVFLAVFVPLVMVHKQRFMKVADDRYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGGSAMMLFSLLFGCFLLISQVI
CCCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNIKMMGSSLIIAGTALGAGMLAIPMVLAQFGLLYGTLLMVLICFGTTYAALLLLEATIK
CCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGGLGLNSIARKTLGKQGQLITNGLLYALLICLLMAYILGAGDLLSKLLSNLGVDISAT
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
TSQITFTLLAGAVVASGTGVIDKLNRALFFVMLASLFATMVFLAPSMTQENLMQVTSHDH
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
VDLIKTSAILFTSFGFMVVIPTLVSYNHEATDKQLRNMVIIGSLIPLVCYLCWLFAVVGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSEEQFRSFENVSDLMAAFEAQSPWVGNVLSTFTGLALLTSFFGVAMALFNQNKDMFNQN
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
TAVTYCISFILPLAGSLLAADKFLQVLNYAGIILVFLAVFVPLVMVHKQRFMKVADDRYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGGSAMMLFSLLFGCFLLISQVI
CCCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]