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The map label for this gene is czcD [H]

Identifier: 218709628

GI number: 218709628

Start: 1758468

End: 1759466

Strand: Reverse

Name: czcD [H]

Synonym: VS_1638

Alternate gene names: 218709628

Gene position: 1759466-1758468 (Counterclockwise)

Preceding gene: 218709630

Following gene: 218709627

Centisome position: 53.33

GC content: 44.34

Gene sequence:

>999_bases
TTGAGTTTTCCAACACGTCACCAACACAACTTTTCTTCACATAACAGCCAAGGTGAGAAACGCACGTTCTATGTCCTGTT
ATTGACCGTCGTTACCATGGTTGTCGAAATCGTTGCGGGTACCATTTATGGTTCAATGGCATTGCTTGCTGATGGTTGGC
ACATGGGAACGCATGCTGCTGCGTTTGGTATCACCTTATTTGCATACCGATATGCGAAGAAACATGCCGAGAGTGAACGT
TTCTCGTTTGGTACTGGCAAAGTCAGCGTGTTAGGGGGCTACACCAGCGCGATTGCATTGGGTATTGTGTCATTATTGAT
GCTGGTGGAATCAGTGCATCGTTTATTTAACCCACAAGCGATTCAGTTCAATGAAGCGATCATCGTTGCCTGTATTGGTT
TAACTGTGAATGTGGTGAGTATGTTTTTACTCGGCGATCACCATCATGATCACGGACACGAGCATGGCCACGATCATAGT
AACAATCATAGTAAGAATCACGGTCATTCACATAGCCATGATCACGACAGCGACCATAATCATAAGCATGGTGAGCACCA
TCATGACCATAACCTACGCGCAGCCTACATGCATGTGTTGGCGGATACGTTGACTTCACTGTTGGCCATTGTTGCGCTGC
TGTTTGGTAAGTTTTACGGTTGGAACTGGTTAGATGCAGCAATGGGAATGGTTGGCGCATTTGTGATTGCTAAGTGGACG
ATGAACCTTATGAAACAAACCAGTCCAATCCTGCTTGATGAGAATATCCACCAAGATTATCGCGACTCAGTGACCGAAAC
CTTAACGCCTTATGCGTCGGTCACCGATTTCCATATGTGGAAGGTGAGTGGGCATCACTATTCAGCAGCAATTACTCTTG
AATCAAACAGTGATAAAACCGTGTCTGAATATAAACAAATGCTCTCCAAGTTTGATAAGATTAATCATCTTACTCTTGAA
GTGCATTCAAACGACCATGCGAAATATAGAACAGCTTAA

Upstream 100 bases:

>100_bases
AAATTTCAACCAATTGATTTGATTGTCAAATTACTTGTCAATCAAAGTGCTTTTATTAACAACGATCATCTAACCGCAAG
CATCAGCTAAGGACGCCATT

Downstream 100 bases:

>100_bases
CCAAATACTGACTGAGTTCTACGATAAAATGTCTTCGTGGGAACAGTCTGTAGTCAAAGAGACGGGTTACTCCCTGGCTC
AAGTACACACTATTGAAGTA

Product: putative transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSFPTRHQHNFSSHNSQGEKRTFYVLLLTVVTMVVEIVAGTIYGSMALLADGWHMGTHAAAFGITLFAYRYAKKHAESER
FSFGTGKVSVLGGYTSAIALGIVSLLMLVESVHRLFNPQAIQFNEAIIVACIGLTVNVVSMFLLGDHHHDHGHEHGHDHS
NNHSKNHGHSHSHDHDSDHNHKHGEHHHDHNLRAAYMHVLADTLTSLLAIVALLFGKFYGWNWLDAAMGMVGAFVIAKWT
MNLMKQTSPILLDENIHQDYRDSVTETLTPYASVTDFHMWKVSGHHYSAAITLESNSDKTVSEYKQMLSKFDKINHLTLE
VHSNDHAKYRTA

Sequences:

>Translated_332_residues
MSFPTRHQHNFSSHNSQGEKRTFYVLLLTVVTMVVEIVAGTIYGSMALLADGWHMGTHAAAFGITLFAYRYAKKHAESER
FSFGTGKVSVLGGYTSAIALGIVSLLMLVESVHRLFNPQAIQFNEAIIVACIGLTVNVVSMFLLGDHHHDHGHEHGHDHS
NNHSKNHGHSHSHDHDSDHNHKHGEHHHDHNLRAAYMHVLADTLTSLLAIVALLFGKFYGWNWLDAAMGMVGAFVIAKWT
MNLMKQTSPILLDENIHQDYRDSVTETLTPYASVTDFHMWKVSGHHYSAAITLESNSDKTVSEYKQMLSKFDKINHLTLE
VHSNDHAKYRTA
>Mature_331_residues
SFPTRHQHNFSSHNSQGEKRTFYVLLLTVVTMVVEIVAGTIYGSMALLADGWHMGTHAAAFGITLFAYRYAKKHAESERF
SFGTGKVSVLGGYTSAIALGIVSLLMLVESVHRLFNPQAIQFNEAIIVACIGLTVNVVSMFLLGDHHHDHGHEHGHDHSN
NHSKNHGHSHSHDHDSDHNHKHGEHHHDHNLRAAYMHVLADTLTSLLAIVALLFGKFYGWNWLDAAMGMVGAFVIAKWTM
NLMKQTSPILLDENIHQDYRDSVTETLTPYASVTDFHMWKVSGHHYSAAITLESNSDKTVSEYKQMLSKFDKINHLTLEV
HSNDHAKYRTA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=317, Percent_Identity=27.1293375394322, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI222080086, Length=316, Percent_Identity=23.4177215189873, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI40255009, Length=316, Percent_Identity=23.4177215189873, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21359890, Length=310, Percent_Identity=25.1612903225806, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI52352803, Length=377, Percent_Identity=22.5464190981432, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=31.496062992126, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=270, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564488, Length=265, Percent_Identity=30.188679245283, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193210990, Length=323, Percent_Identity=26.9349845201238, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555794, Length=319, Percent_Identity=26.0188087774295, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17555796, Length=319, Percent_Identity=26.0188087774295, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550440, Length=204, Percent_Identity=26.9607843137255, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17550442, Length=204, Percent_Identity=26.9607843137255, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=354, Percent_Identity=26.5536723163842, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324892, Length=340, Percent_Identity=21.7647058823529, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=227, Percent_Identity=27.7533039647577, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656728, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656724, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656720, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656715, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357035, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645863, Length=295, Percent_Identity=24.7457627118644, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24585900, Length=145, Percent_Identity=28.9655172413793, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585898, Length=145, Percent_Identity=28.9655172413793, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585896, Length=145, Percent_Identity=28.9655172413793, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921672, Length=145, Percent_Identity=28.9655172413793, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 37272; Mature: 37140

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SFPTRHQHNFSSHNSQGEKRTFYVLLLTVVTMVVEIVAGTIYGSMALLADGWHMGTHAA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AFGITLFAYRYAKKHAESERFSFGTGKVSVLGGYTSAIALGIVSLLMLVESVHRLFNPQA
HHHHHHHHHHHHHHHCCCHHEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCE
IQFNEAIIVACIGLTVNVVSMFLLGDHHHDHGHEHGHDHSNNHSKNHGHSHSHDHDSDHN
EEECCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HKHGEHHHDHNLRAAYMHVLADTLTSLLAIVALLFGKFYGWNWLDAAMGMVGAFVIAKWT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MNLMKQTSPILLDENIHQDYRDSVTETLTPYASVTDFHMWKVSGHHYSAAITLESNSDKT
HHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEECCCCCH
VSEYKQMLSKFDKINHLTLEVHSNDHAKYRTA
HHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]