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The map label for this gene is serA [H]

Identifier: 218709599

GI number: 218709599

Start: 1725337

End: 1726341

Strand: Reverse

Name: serA [H]

Synonym: VS_1609

Alternate gene names: 218709599

Gene position: 1726341-1725337 (Counterclockwise)

Preceding gene: 218709600

Following gene: 218709598

Centisome position: 52.32

GC content: 46.87

Gene sequence:

>1005_bases
ATGGCACTTGAGCCTTCATTTGACCAATACAAGATAACTAACAATCAAAAGGAGAGTGATGTGAAAATAGCGATATTGGA
TGACTACCAGAACGTCGTTAAAGACCTCGACTGCTTCAACAAACTTGAACAACACGATGTCACGGTATTTACCCAGACTT
TCTCAGAGCAAGAGCTCGTCGCTAAGTTGGTCCCGTTTGAAGCCATTGTGCTCATTCGTGAAAGAACCGAGATCACCGAA
TCTTTGTTATCGCAGCTGCCAAACCTCAAGCTGATTAGCCAGACGGGCAAAGTGAGTAATCATATCGACCCGCAAATGTG
CGAGCGATTTGGTGTTACCGTTTTAGAAGGCCGAGGCTCGCCAGTTGCACCCTCTGAATTATGCTGGGCGTTGATTATGG
CTGCATCGCGCCACATTCCCACTTACGCTTCAAACCTTAAACAGAACCAGTGGCAGGATTCTGGCTCGTTAGGGCTAGGT
CGAACTTTGAAAGGCTTGAAGCTAGGTATTTGGGGCTACGGCAAGATCGGCAAATGCATTGCACAATATGCCCAAGTATT
TGGGATGTCTGTCGTAGTGTGGGGTAGCAAAGCTTCACGCGATCAGGCGCAAGCAGATGGTTTTGAAGCAGCAACAACCA
AACAAGACTTCTTCCGAGAAGTTGATGTGTTTTCTTTGCATTTACGTTTGAATGATGCGACCAGAGGATGTGTTACGGCA
CACGATCTAAGCTTGATGAAGCCGGACTCACTGTTTGTGAACATCAGCCGTGCCGAGTTAGTCGAACCGATGGCCCTTTA
TCATGAACTACGCGAGATACCGACCAAAACAGCCGCTATTGATGTGTTCGATTGTGAGCCAGTAACTACAGACTCCGAAC
CGCTACTGTCCTTACCAAATGTCACTGCAACTCCACATTTGGGCTATGTTGAACAAAATAGCTACGAACTCTACTTCGAT
ATCGCCTTCGACAACATTCTGTCCTATCAAAAGGATGGCGCATAG

Upstream 100 bases:

>100_bases
CAAGATCTCACCAAGTGAAGACATGTTACTTATGTTGGAGCGTTTTAAAGTGGTTTATAAATAGTGAAGTCCCAGCGCGT
GATGTGTTGAATCGGAAGGC

Downstream 100 bases:

>100_bases
CGATAGAATCTGCCCAAAGCAATAAAAAGGTAGAGAAGTATGAGCTTAACAATCAGAGAAGTCGCGGTAGAAGATGCACA
AGGCATTATTGATGTATTGA

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MALEPSFDQYKITNNQKESDVKIAILDDYQNVVKDLDCFNKLEQHDVTVFTQTFSEQELVAKLVPFEAIVLIRERTEITE
SLLSQLPNLKLISQTGKVSNHIDPQMCERFGVTVLEGRGSPVAPSELCWALIMAASRHIPTYASNLKQNQWQDSGSLGLG
RTLKGLKLGIWGYGKIGKCIAQYAQVFGMSVVVWGSKASRDQAQADGFEAATTKQDFFREVDVFSLHLRLNDATRGCVTA
HDLSLMKPDSLFVNISRAELVEPMALYHELREIPTKTAAIDVFDCEPVTTDSEPLLSLPNVTATPHLGYVEQNSYELYFD
IAFDNILSYQKDGA

Sequences:

>Translated_334_residues
MALEPSFDQYKITNNQKESDVKIAILDDYQNVVKDLDCFNKLEQHDVTVFTQTFSEQELVAKLVPFEAIVLIRERTEITE
SLLSQLPNLKLISQTGKVSNHIDPQMCERFGVTVLEGRGSPVAPSELCWALIMAASRHIPTYASNLKQNQWQDSGSLGLG
RTLKGLKLGIWGYGKIGKCIAQYAQVFGMSVVVWGSKASRDQAQADGFEAATTKQDFFREVDVFSLHLRLNDATRGCVTA
HDLSLMKPDSLFVNISRAELVEPMALYHELREIPTKTAAIDVFDCEPVTTDSEPLLSLPNVTATPHLGYVEQNSYELYFD
IAFDNILSYQKDGA
>Mature_333_residues
ALEPSFDQYKITNNQKESDVKIAILDDYQNVVKDLDCFNKLEQHDVTVFTQTFSEQELVAKLVPFEAIVLIRERTEITES
LLSQLPNLKLISQTGKVSNHIDPQMCERFGVTVLEGRGSPVAPSELCWALIMAASRHIPTYASNLKQNQWQDSGSLGLGR
TLKGLKLGIWGYGKIGKCIAQYAQVFGMSVVVWGSKASRDQAQADGFEAATTKQDFFREVDVFSLHLRLNDATRGCVTAH
DLSLMKPDSLFVNISRAELVEPMALYHELREIPTKTAAIDVFDCEPVTTDSEPLLSLPNVTATPHLGYVEQNSYELYFDI
AFDNILSYQKDGA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=261, Percent_Identity=27.2030651340996, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI61743967, Length=285, Percent_Identity=27.719298245614, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI4557497, Length=285, Percent_Identity=27.719298245614, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=26.4285714285714, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=26.4285714285714, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI145580575, Length=329, Percent_Identity=25.8358662613982, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=26.9387755102041, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789279, Length=270, Percent_Identity=29.2592592592593, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87082289, Length=299, Percent_Identity=26.7558528428094, Blast_Score=95, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=312, Percent_Identity=27.8846153846154, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=25, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=181, Percent_Identity=27.0718232044199, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=283, Percent_Identity=25.0883392226148, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921140, Length=278, Percent_Identity=28.7769784172662, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=27.1653543307087, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=25.609756097561, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=25.609756097561, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=25.609756097561, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=25.609756097561, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24585516, Length=207, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=25.1824817518248, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45552429, Length=289, Percent_Identity=25.2595155709343, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585514, Length=289, Percent_Identity=25.2595155709343, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574282, Length=289, Percent_Identity=25.2595155709343, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28574284, Length=289, Percent_Identity=25.2595155709343, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45551003, Length=289, Percent_Identity=25.2595155709343, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=26.0700389105058, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37305; Mature: 37174

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEPSFDQYKITNNQKESDVKIAILDDYQNVVKDLDCFNKLEQHDVTVFTQTFSEQELV
CCCCCCCCCEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHH
AKLVPFEAIVLIRERTEITESLLSQLPNLKLISQTGKVSNHIDPQMCERFGVTVLEGRGS
HHHCCHHHEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHCCEEEECCCC
PVAPSELCWALIMAASRHIPTYASNLKQNQWQDSGSLGLGRTLKGLKLGIWGYGKIGKCI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
AQYAQVFGMSVVVWGSKASRDQAQADGFEAATTKQDFFREVDVFSLHLRLNDATRGCVTA
HHHHHHHCCEEEEECCCCCCCHHHHCCCCHHCCHHHHHHHCCEEEEEEEECCCCCCCEEE
HDLSLMKPDSLFVNISRAELVEPMALYHELREIPTKTAAIDVFDCEPVTTDSEPLLSLPN
CCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEECCC
VTATPHLGYVEQNSYELYFDIAFDNILSYQKDGA
CCCCCCCCEEECCCEEEEEEEEHHHHHHHCCCCC
>Mature Secondary Structure 
ALEPSFDQYKITNNQKESDVKIAILDDYQNVVKDLDCFNKLEQHDVTVFTQTFSEQELV
CCCCCCCCEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHH
AKLVPFEAIVLIRERTEITESLLSQLPNLKLISQTGKVSNHIDPQMCERFGVTVLEGRGS
HHHCCHHHEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHCCEEEECCCC
PVAPSELCWALIMAASRHIPTYASNLKQNQWQDSGSLGLGRTLKGLKLGIWGYGKIGKCI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
AQYAQVFGMSVVVWGSKASRDQAQADGFEAATTKQDFFREVDVFSLHLRLNDATRGCVTA
HHHHHHHCCEEEEECCCCCCCHHHHCCCCHHCCHHHHHHHCCEEEEEEEECCCCCCCEEE
HDLSLMKPDSLFVNISRAELVEPMALYHELREIPTKTAAIDVFDCEPVTTDSEPLLSLPN
CCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEECCC
VTATPHLGYVEQNSYELYFDIAFDNILSYQKDGA
CCCCCCCCEEECCCEEEEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]