Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 218709489

GI number: 218709489

Start: 1632529

End: 1634058

Strand: Reverse

Name: atoC [H]

Synonym: VS_1498

Alternate gene names: 218709489

Gene position: 1634058-1632529 (Counterclockwise)

Preceding gene: 218709495

Following gene: 218709488

Centisome position: 49.53

GC content: 45.75

Gene sequence:

>1530_bases
TTGTCCCTGTCGCACAAAAGGTTAATTGGTACACTCTGTCCCAACTTTCCCCATCGGCTAATCATTATGTCTTTACCTAG
TTCACCTGCATCGAACCTCAACCCAAACACATTGACTCAATATCAAGCGTTTTCCGTCTTGGTCGTGGACGATGAAGTAG
GGATGCAGGCTATTCTAAAGAAGGCTCTGGGTAAGTTCTTTGGCAAGGTATCGAGTGCAGGATCCGTTGAAGAAGCTGAA
ATACTGCGTTCAAGCGAACATTTTGATCTCATTGTTCTTGATATCAACCTGCCAGGACGCTCCGGCATTGAGTGGGAAGA
GGCTTTTAACGACAACGACAAACGAGCTGATGTTATTTTCATGACTGGCTATGCTGATCTAGAGATGACCATATCCGCGC
TTAAGCTTGGCGCTTCAGACTTCATTCTTAAACCTTTCAACTTAGAACAAATGATACAAGCTGTACTACGTTGTATGGAT
AAGCGCCTTGATCAAAGAATGCAATACGCATTGAAGCGTGATGTTAGCCGTCATATCAAGACCGAGTTAATCGGTAACTC
AGATAAAACCAAACAGCTTAAATTGCTGATCAGTCAATTTGCACCCTCTCGAGCATCCGTTCTTATAGAAGGTGAGTCAG
GTACAGGTAAAGAGCTAGTTGCACGTGGTGTACATGAAGCCAGTAAACGCACTGGGCCATTTGTGCCAATCAACTGTGGC
GCAATCGCCCCAGAACTTCTAGAAAGTGAACTATTCGGGCATACCTCTGGCGCATTTACCGGCGCGAAGAAAAACCGTGA
AGGTCTATTCAGAGTCGCAAGTGGTGGCACCTTGTTCCTTGATGAAATCGGTGAGATGCCACTGCCAATGCAAGCAGCGC
TGTTGCGTGTGTTAGAGCAACGCACTATTCGTCCAGTCGGTAGCGAGAAAGAAATTGCCGTTGACGTACGAGTAGTGGCG
GCGACTAACCGAAACCTTCAACAAGAGGTCGAAAAAGGGCACTTCCGTCGCGATCTATTCTACCGACTCAATGTCCTTAA
AATTGATGTTGTGCCATTGAGAGAACGTCCATCAGATTTAATTGAGCTTGTTCCGTATTTCACTCGTCTTTTAGCAAGTG
AACTTAGTGTACCGGTCCCAAACTGGGCGCATGAAGATATCTTGGCGATGAATGAATACGAATGGCCAGGAAATATTCGC
GAACTCAAGAACCTAGTCGAAAGATGCATTCTTTTAGACAAGCCACCAGCGCACTATTGGCGCGAAATTAATGGCGATCC
TGCGCCCACCAGCATTTCAGTGACGGTGTCACATGGAGCAGAAATACCAAACTTGAATAACGTAGACGCTGCAGAAGGTT
ACCCCAACACTTGGACACTCAAAGAAGTAGAAAAATCTCACATCGAGCAACTGGTGAGTTTTCATGATGGTAATAAATCC
GCAGCTGCAAGAGACCTCGGCGTTGCACGGAAAACGCTAGAGCGTAAATATAAAGATTGGAACACAGAAGGATCTGAATA
TGCCGATTAG

Upstream 100 bases:

>100_bases
GTGCATCAAATTTCATTAAATTGCTGTTATATCAAACAAAACTGCGTCATTTAGGCTAACAAAATGCATTAAAATATGAG
CTAGGACAAAATGTCGCACA

Downstream 100 bases:

>100_bases
ACGTCATTGGTGGTCAAAGTGGACGTTTCGGTTCAAAACCATGGTGCGTTATCGTCTGTTATTTTTGACGTCAGCGCCGA
TCATCTTAACTTTATGCGCT

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSLSHKRLIGTLCPNFPHRLIIMSLPSSPASNLNPNTLTQYQAFSVLVVDDEVGMQAILKKALGKFFGKVSSAGSVEEAE
ILRSSEHFDLIVLDINLPGRSGIEWEEAFNDNDKRADVIFMTGYADLEMTISALKLGASDFILKPFNLEQMIQAVLRCMD
KRLDQRMQYALKRDVSRHIKTELIGNSDKTKQLKLLISQFAPSRASVLIEGESGTGKELVARGVHEASKRTGPFVPINCG
AIAPELLESELFGHTSGAFTGAKKNREGLFRVASGGTLFLDEIGEMPLPMQAALLRVLEQRTIRPVGSEKEIAVDVRVVA
ATNRNLQQEVEKGHFRRDLFYRLNVLKIDVVPLRERPSDLIELVPYFTRLLASELSVPVPNWAHEDILAMNEYEWPGNIR
ELKNLVERCILLDKPPAHYWREINGDPAPTSISVTVSHGAEIPNLNNVDAAEGYPNTWTLKEVEKSHIEQLVSFHDGNKS
AAARDLGVARKTLERKYKDWNTEGSEYAD

Sequences:

>Translated_509_residues
MSLSHKRLIGTLCPNFPHRLIIMSLPSSPASNLNPNTLTQYQAFSVLVVDDEVGMQAILKKALGKFFGKVSSAGSVEEAE
ILRSSEHFDLIVLDINLPGRSGIEWEEAFNDNDKRADVIFMTGYADLEMTISALKLGASDFILKPFNLEQMIQAVLRCMD
KRLDQRMQYALKRDVSRHIKTELIGNSDKTKQLKLLISQFAPSRASVLIEGESGTGKELVARGVHEASKRTGPFVPINCG
AIAPELLESELFGHTSGAFTGAKKNREGLFRVASGGTLFLDEIGEMPLPMQAALLRVLEQRTIRPVGSEKEIAVDVRVVA
ATNRNLQQEVEKGHFRRDLFYRLNVLKIDVVPLRERPSDLIELVPYFTRLLASELSVPVPNWAHEDILAMNEYEWPGNIR
ELKNLVERCILLDKPPAHYWREINGDPAPTSISVTVSHGAEIPNLNNVDAAEGYPNTWTLKEVEKSHIEQLVSFHDGNKS
AAARDLGVARKTLERKYKDWNTEGSEYAD
>Mature_508_residues
SLSHKRLIGTLCPNFPHRLIIMSLPSSPASNLNPNTLTQYQAFSVLVVDDEVGMQAILKKALGKFFGKVSSAGSVEEAEI
LRSSEHFDLIVLDINLPGRSGIEWEEAFNDNDKRADVIFMTGYADLEMTISALKLGASDFILKPFNLEQMIQAVLRCMDK
RLDQRMQYALKRDVSRHIKTELIGNSDKTKQLKLLISQFAPSRASVLIEGESGTGKELVARGVHEASKRTGPFVPINCGA
IAPELLESELFGHTSGAFTGAKKNREGLFRVASGGTLFLDEIGEMPLPMQAALLRVLEQRTIRPVGSEKEIAVDVRVVAA
TNRNLQQEVEKGHFRRDLFYRLNVLKIDVVPLRERPSDLIELVPYFTRLLASELSVPVPNWAHEDILAMNEYEWPGNIRE
LKNLVERCILLDKPPAHYWREINGDPAPTSISVTVSHGAEIPNLNNVDAAEGYPNTWTLKEVEKSHIEQLVSFHDGNKSA
AARDLGVARKTLERKYKDWNTEGSEYAD

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=472, Percent_Identity=36.6525423728814, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI1790437, Length=451, Percent_Identity=39.0243902439024, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=35.3191489361702, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1789233, Length=325, Percent_Identity=43.6923076923077, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1786524, Length=337, Percent_Identity=40.9495548961424, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1788905, Length=384, Percent_Identity=35.9375, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082117, Length=322, Percent_Identity=40.9937888198758, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=238, Percent_Identity=50, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=40.3076923076923, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1787583, Length=341, Percent_Identity=37.2434017595308, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87081872, Length=271, Percent_Identity=41.3284132841328, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1789828, Length=215, Percent_Identity=40, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87081858, Length=330, Percent_Identity=29.0909090909091, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 56851; Mature: 56720

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSHKRLIGTLCPNFPHRLIIMSLPSSPASNLNPNTLTQYQAFSVLVVDDEVGMQAILK
CCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECHHHHHHHHH
KALGKFFGKVSSAGSVEEAEILRSSEHFDLIVLDINLPGRSGIEWEEAFNDNDKRADVIF
HHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCEEEEE
MTGYADLEMTISALKLGASDFILKPFNLEQMIQAVLRCMDKRLDQRMQYALKRDVSRHIK
EECCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELIGNSDKTKQLKLLISQFAPSRASVLIEGESGTGKELVARGVHEASKRTGPFVPINCG
HHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECC
AIAPELLESELFGHTSGAFTGAKKNREGLFRVASGGTLFLDEIGEMPLPMQAALLRVLEQ
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHCCCCCCHHHHHHHHHHH
RTIRPVGSEKEIAVDVRVVAATNRNLQQEVEKGHFRRDLFYRLNVLKIDVVPLRERPSDL
HCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCHHHH
IELVPYFTRLLASELSVPVPNWAHEDILAMNEYEWPGNIRELKNLVERCILLDKPPAHYW
HHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
REINGDPAPTSISVTVSHGAEIPNLNNVDAAEGYPNTWTLKEVEKSHIEQLVSFHDGNKS
HHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCH
AAARDLGVARKTLERKYKDWNTEGSEYAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLSHKRLIGTLCPNFPHRLIIMSLPSSPASNLNPNTLTQYQAFSVLVVDDEVGMQAILK
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECHHHHHHHHH
KALGKFFGKVSSAGSVEEAEILRSSEHFDLIVLDINLPGRSGIEWEEAFNDNDKRADVIF
HHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHCCCCCCCEEEEE
MTGYADLEMTISALKLGASDFILKPFNLEQMIQAVLRCMDKRLDQRMQYALKRDVSRHIK
EECCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TELIGNSDKTKQLKLLISQFAPSRASVLIEGESGTGKELVARGVHEASKRTGPFVPINCG
HHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECC
AIAPELLESELFGHTSGAFTGAKKNREGLFRVASGGTLFLDEIGEMPLPMQAALLRVLEQ
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHCCCCCCHHHHHHHHHHH
RTIRPVGSEKEIAVDVRVVAATNRNLQQEVEKGHFRRDLFYRLNVLKIDVVPLRERPSDL
HCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCHHHH
IELVPYFTRLLASELSVPVPNWAHEDILAMNEYEWPGNIRELKNLVERCILLDKPPAHYW
HHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
REINGDPAPTSISVTVSHGAEIPNLNNVDAAEGYPNTWTLKEVEKSHIEQLVSFHDGNKS
HHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCH
AAARDLGVARKTLERKYKDWNTEGSEYAD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]