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The map label for this gene is pyrD [H]

Identifier: 218709413

GI number: 218709413

Start: 1562494

End: 1563504

Strand: Direct

Name: pyrD [H]

Synonym: VS_1422

Alternate gene names: 218709413

Gene position: 1562494-1563504 (Clockwise)

Preceding gene: 218709412

Following gene: 218709414

Centisome position: 47.36

GC content: 42.93

Gene sequence:

>1011_bases
ATGCTCTACCGTCTAGCCAGAACTGGCTTTTTCCAACTTGATGCCGAAAAGGCACATGATCTTGCAATTCAAAATTTCAA
ACGCTTCACAGGCACTCCTATTGATCTTTTGTATCGCCAACAATTACCTAATCGACCTGTAGAATGCATGGGTCTTACTT
TTAAAAACCCAGTTGGCCTAGCGGCTGGCCTAGATAAAAACGGCGAATGTATTGATGCATTTGGCGCAATGGGTTTTGGT
TTCGTTGAAGTAGGAACGGTAACTCCTCGTCCACAAGCCGGTAATGACAAACCACGTCTGTTCCGTCTTGTTGAAGCTGA
AGGTATCATCAACCGCATGGGGTTCAATAACCTAGGCGTCGACAATCTTATTGAGAACGTTAAGAAGTCGAACTACGACG
GCATCTTAGGTATCAACATCGGTAAGAACAAAGACACACCAATTGAAAAGGGCGCTGAAGATTACTTGATCTGTATGGAG
AAGGTATATCAATACGCTGGTTACATTGCTGTGAATATCTCTTCACCAAATACTCCAGGACTTCGTTCTCTACAATACGG
CGAAGCTCTAGACGATCTATTGTCTGAACTTAAAACAAAACAATCTGAACTAGAAGAGAAGCATGGTAAATATGTTCCTC
TTGCTCTTAAGATTGCTCCGGATCTAAGTGATGACGAAATTAGCCAAATTTGTGAATCATTGATCAAAAATAAGATCGAT
GGTGTGATCGCAACAAACACAACATTGGATCGTTCAATCGTTGAAGGCATGAAACATTGCGATGAAGCGGGTGGCCTAAG
TGGACGTCCGGTTCAATCTCGCAGTACTGAAGTGGTTCGTAAACTTCACGAAGAACTTGGTGACGCATTGCCGATCATTG
GAGTAGGTGGCGTTGATTCTTACGTTGCTGCAAAAGAGAAAATGATGGCAGGCGCGAAGCTTGTACAAGTTTACTCTGGT
TTCATCTACAAAGGCCCAGGTCTTGTAGGCGACATCGTTAAAAATTTATAG

Upstream 100 bases:

>100_bases
GATTATCTTACCCTTACAGACAGTAATAGATTGAATAGTTGGGTAAATAAGTAAATAATATCGCCCCGTTTACACGGGGC
TTTTTTCTATCGGAGGCACA

Downstream 100 bases:

>100_bases
TCCCCGAAAACCAGAGCTTTTATAAACCCAGAGCTTTTATAAACAGAGTTATCAAAAAGATTTGGTTTTTTTAGGAAAGC
TATAATTTGGCATCGTCTTG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYRLARTGFFQLDAEKAHDLAIQNFKRFTGTPIDLLYRQQLPNRPVECMGLTFKNPVGLAAGLDKNGECIDAFGAMGFG
FVEVGTVTPRPQAGNDKPRLFRLVEAEGIINRMGFNNLGVDNLIENVKKSNYDGILGINIGKNKDTPIEKGAEDYLICME
KVYQYAGYIAVNISSPNTPGLRSLQYGEALDDLLSELKTKQSELEEKHGKYVPLALKIAPDLSDDEISQICESLIKNKID
GVIATNTTLDRSIVEGMKHCDEAGGLSGRPVQSRSTEVVRKLHEELGDALPIIGVGGVDSYVAAKEKMMAGAKLVQVYSG
FIYKGPGLVGDIVKNL

Sequences:

>Translated_336_residues
MLYRLARTGFFQLDAEKAHDLAIQNFKRFTGTPIDLLYRQQLPNRPVECMGLTFKNPVGLAAGLDKNGECIDAFGAMGFG
FVEVGTVTPRPQAGNDKPRLFRLVEAEGIINRMGFNNLGVDNLIENVKKSNYDGILGINIGKNKDTPIEKGAEDYLICME
KVYQYAGYIAVNISSPNTPGLRSLQYGEALDDLLSELKTKQSELEEKHGKYVPLALKIAPDLSDDEISQICESLIKNKID
GVIATNTTLDRSIVEGMKHCDEAGGLSGRPVQSRSTEVVRKLHEELGDALPIIGVGGVDSYVAAKEKMMAGAKLVQVYSG
FIYKGPGLVGDIVKNL
>Mature_336_residues
MLYRLARTGFFQLDAEKAHDLAIQNFKRFTGTPIDLLYRQQLPNRPVECMGLTFKNPVGLAAGLDKNGECIDAFGAMGFG
FVEVGTVTPRPQAGNDKPRLFRLVEAEGIINRMGFNNLGVDNLIENVKKSNYDGILGINIGKNKDTPIEKGAEDYLICME
KVYQYAGYIAVNISSPNTPGLRSLQYGEALDDLLSELKTKQSELEEKHGKYVPLALKIAPDLSDDEISQICESLIKNKID
GVIATNTTLDRSIVEGMKHCDEAGGLSGRPVQSRSTEVVRKLHEELGDALPIIGVGGVDSYVAAKEKMMAGAKLVQVYSG
FIYKGPGLVGDIVKNL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=335, Percent_Identity=42.3880597014925, Blast_Score=232, Evalue=3e-61,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=69.6428571428571, Blast_Score=515, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17509475, Length=333, Percent_Identity=41.4414414414414, Blast_Score=230, Evalue=7e-61,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.6829268292683, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.6829268292683, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36673; Mature: 36673

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRLARTGFFQLDAEKAHDLAIQNFKRFTGTPIDLLYRQQLPNRPVECMGLTFKNPVGL
CCEEECCCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEECEECCCCCC
AAGLDKNGECIDAFGAMGFGFVEVGTVTPRPQAGNDKPRLFRLVEAEGIINRMGFNNLGV
EECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCH
DNLIENVKKSNYDGILGINIGKNKDTPIEKGAEDYLICMEKVYQYAGYIAVNISSPNTPG
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRSLQYGEALDDLLSELKTKQSELEEKHGKYVPLALKIAPDLSDDEISQICESLIKNKID
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSIVEGMKHCDEAGGLSGRPVQSRSTEVVRKLHEELGDALPIIGVGGVDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMMAGAKLVQVYSGFIYKGPGLVGDIVKNL
HHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHCC
>Mature Secondary Structure
MLYRLARTGFFQLDAEKAHDLAIQNFKRFTGTPIDLLYRQQLPNRPVECMGLTFKNPVGL
CCEEECCCCCEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHEECEECCCCCC
AAGLDKNGECIDAFGAMGFGFVEVGTVTPRPQAGNDKPRLFRLVEAEGIINRMGFNNLGV
EECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCH
DNLIENVKKSNYDGILGINIGKNKDTPIEKGAEDYLICMEKVYQYAGYIAVNISSPNTPG
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRSLQYGEALDDLLSELKTKQSELEEKHGKYVPLALKIAPDLSDDEISQICESLIKNKID
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSIVEGMKHCDEAGGLSGRPVQSRSTEVVRKLHEELGDALPIIGVGGVDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMMAGAKLVQVYSGFIYKGPGLVGDIVKNL
HHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA