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The map label for this gene is hutC [H]

Identifier: 218709213

GI number: 218709213

Start: 1296894

End: 1297607

Strand: Reverse

Name: hutC [H]

Synonym: VS_1220

Alternate gene names: 218709213

Gene position: 1297607-1296894 (Counterclockwise)

Preceding gene: 218709219

Following gene: 218709212

Centisome position: 39.33

GC content: 43.7

Gene sequence:

>714_bases
ATGTCGAAAGCGCCGCTCTACCTTCAGATAAAACAGTTCATAGATGACAAGATCAACAGTGGTCATTGGCCGGTTGGTTA
TCAAATCACTACAGAGCTCGAACTCACCGAGCAGTTCAATGTGAGTCGAATGACGGTCAATAAAGCCATTCGAGATCTGG
TGTCTGAAGGCAAGCTAATTAGGAAGCCAAGGCTGGGTACTTTTGTTTGTGAACCAGACGAAAAGGCGCAATCTCCGCTG
CTTGATATCAACAACATCGCACAAGAAATCAAAGACCGAGGCCAAACGTATACTAGTCAAGTTATCAAACACGATAGCAT
CAAGGCCGATGAAAGCACGGCTACACGGTTAGGAGTGATGATTAACGCTGAAGTGTTTTATAGTGAAATCATCCACTTTG
CCGACAATACACCGATACAATTGGAAGCGCGCTGGGTGAACTCTCAAGCCGCTCCAAAATACCTAGAGCAAGACTTTTCA
ACCTCTACACCCAACGAATACCTTTCAAAAAGCTGCCCGTTGAGTGCTATCGAGCATACGGTTGAAGCCATTATTCCTGA
CTCTCAAATTAGAACGTCACTAAAACTTTCTGAATCAGAGCCTTGCCTACTTTTGAATAGAAGAACATGGAGCAAAGAAC
GTCTCATCAGCTTTGCATTGCTCTACCATCCTGGTTCTAAGTACAAATTAAGCTCCAAGATACTTCTAGATTAA

Upstream 100 bases:

>100_bases
TTTGCCCCATCTATGTTGAATAAAGTCACATTGCCCGAGGAAATGTTGAAATCATGAAAAAATCCGTTACTCTATTTGTA
TAGTCAAATAAGGTTTCATT

Downstream 100 bases:

>100_bases
AGAATATCATCCTGATCGCCGATCACATTTTTGCAACATCAACTTGATTCGGGTCAGAGTTTAGCCTATTTATTTGTATA
TACATTTAATGTTTAGTAAA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSKAPLYLQIKQFIDDKINSGHWPVGYQITTELELTEQFNVSRMTVNKAIRDLVSEGKLIRKPRLGTFVCEPDEKAQSPL
LDINNIAQEIKDRGQTYTSQVIKHDSIKADESTATRLGVMINAEVFYSEIIHFADNTPIQLEARWVNSQAAPKYLEQDFS
TSTPNEYLSKSCPLSAIEHTVEAIIPDSQIRTSLKLSESEPCLLLNRRTWSKERLISFALLYHPGSKYKLSSKILLD

Sequences:

>Translated_237_residues
MSKAPLYLQIKQFIDDKINSGHWPVGYQITTELELTEQFNVSRMTVNKAIRDLVSEGKLIRKPRLGTFVCEPDEKAQSPL
LDINNIAQEIKDRGQTYTSQVIKHDSIKADESTATRLGVMINAEVFYSEIIHFADNTPIQLEARWVNSQAAPKYLEQDFS
TSTPNEYLSKSCPLSAIEHTVEAIIPDSQIRTSLKLSESEPCLLLNRRTWSKERLISFALLYHPGSKYKLSSKILLD
>Mature_236_residues
SKAPLYLQIKQFIDDKINSGHWPVGYQITTELELTEQFNVSRMTVNKAIRDLVSEGKLIRKPRLGTFVCEPDEKAQSPLL
DINNIAQEIKDRGQTYTSQVIKHDSIKADESTATRLGVMINAEVFYSEIIHFADNTPIQLEARWVNSQAAPKYLEQDFST
STPNEYLSKSCPLSAIEHTVEAIIPDSQIRTSLKLSESEPCLLLNRRTWSKERLISFALLYHPGSKYKLSSKILLD

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=233, Percent_Identity=24.8927038626609, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082252, Length=151, Percent_Identity=33.112582781457, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786950, Length=205, Percent_Identity=25.3658536585366, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788418, Length=206, Percent_Identity=24.2718446601942, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26945; Mature: 26814

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAPLYLQIKQFIDDKINSGHWPVGYQITTELELTEQFNVSRMTVNKAIRDLVSEGKLI
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHHHCCCEE
RKPRLGTFVCEPDEKAQSPLLDINNIAQEIKDRGQTYTSQVIKHDSIKADESTATRLGVM
ECCCCCEEEECCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHEEEE
INAEVFYSEIIHFADNTPIQLEARWVNSQAAPKYLEQDFSTSTPNEYLSKSCPLSAIEHT
EEHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCHHHHHCCCCHHHHHHH
VEAIIPDSQIRTSLKLSESEPCLLLNRRTWSKERLISFALLYHPGSKYKLSSKILLD
HHHHCCCHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHEEECCCCCEEECCEEECC
>Mature Secondary Structure 
SKAPLYLQIKQFIDDKINSGHWPVGYQITTELELTEQFNVSRMTVNKAIRDLVSEGKLI
CCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHHHCCCEE
RKPRLGTFVCEPDEKAQSPLLDINNIAQEIKDRGQTYTSQVIKHDSIKADESTATRLGVM
ECCCCCEEEECCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHEEEE
INAEVFYSEIIHFADNTPIQLEARWVNSQAAPKYLEQDFSTSTPNEYLSKSCPLSAIEHT
EEHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCHHHHHCCCCHHHHHHH
VEAIIPDSQIRTSLKLSESEPCLLLNRRTWSKERLISFALLYHPGSKYKLSSKILLD
HHHHCCCHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHEEECCCCCEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]