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The map label for this gene is icd2 [H]

Identifier: 218709065

GI number: 218709065

Start: 1126479

End: 1128704

Strand: Direct

Name: icd2 [H]

Synonym: VS_1071

Alternate gene names: 218709065

Gene position: 1126479-1128704 (Clockwise)

Preceding gene: 218709064

Following gene: 218709067

Centisome position: 34.14

GC content: 46.14

Gene sequence:

>2226_bases
ATGCCTACTGAAAAACCAACGATCATCTATACCATTACTGATGAAGCTCCGGCGCTAGCAACTTACTCTCTGCTGCCTAT
CATTCAATCTTTTACGGCTTCTTCTGGTATTAACGTTGATACTCGCGACATTTCACTTGCAGGGCGCATTATTGCCAACT
TCCCTGACTACCTGAACGAAGAGCAACGTATTGGTGATGCATTAGCAGAATTAGGTGAGTTAGCTAAGACACCTGAAGCG
AACATCATCAAGCTTCCAAACATCTCTGCATCTGTTCCTCAACTTCAAGCAACAATCAAAGAGCTTCAGTCAAAAGGTTA
CGCACTTCCTAATTACCCAGAAGAAGCAAACACTGACGAAGAGAAAGCCGTTAAAGCGACTTACGATAAAATCAAAGGCA
GTGCTGTAAACCCTGTGTTACGTGAAGGTAACTCGGATCGCCGCGCTCCACTTTCTGTTAAAAACTACGCGAAGAAGAAC
CCACACTCAATGGGTGCTTGGTCTGCGGATTCTAAGTCGCACGTTTCAAGTATGGACGACAAAGACTTCTTCGGCAGCGA
AAAGTCAGTAACAATTGAAGGTGCTACAGAAGTTAGCATTGAATTCGTTGGTAAAGATGGTGCGAAGAAAACTCTGAAGC
CCGCTTTTGCATTGCAAGATAAAGAGATCATTGATGCGTCAGTGATGAACAAGGCCGCTTTGGTTGCGTTCTTCGAGAAA
GAGATCGCATCAGCTAAAGAGCAAGGTGTACTGCTTTCTCTTCACATGAAAGCGACGATGATGAAAGTATCTGACCCTGT
GATCTTTGGTCATGCAGTTAAGGTTTACTACAAAGACGTATTCGCTAAGCACGGTCAACTGTTTGAAGAGCTTGGTGTTG
ATGTAAACAACGGCATCGGCGATGTATACGCAAAAATTGCTGCGCTTCCTCAAGAGCAGAAAGAAGCGATTGAAGCTGAC
CTACAAGCGGTATACGAGACTCAACCACCACTAGCGATGGTTGATTCGGATCGCGGCATTACTAACCTACACGTTCCAAG
CGACATCATTGTTGATGCATCTATGCCTGCAATGCTGCGTTCTTCAGGTCAAATGTGGGATCCAGAAGGTAAGCAAAAAG
ACACGAAAGCTATGATTCCTGATCGCAGCTACGCAAGCATCTACCAAGCAGTTATTGATTTCTGCAAAGAGAATGGTGCT
TTCGATCCAACAACAATGGGTAGTGTACCAAACGTTGGCTTGATGGCTCAAAAAGCCGAAGAGTACGGTTCTCACGATAA
GACTTTTATCCTTGAAGCTGCTGGTCAGGTTCAAGTTGTTGACGCTTCAGGCGTTGTGCTTCTAGAGCAAGACGTAGAGG
AAGGTGATATCTTCCGTATGTGTCAGGTTAAAGATGCACCGATTCAAGACTGGGTTAAGCTAGCGGTAACTCGTGCTCGT
GCTTCGGGGGTTCCTGCAGTATTCTGGCTAGACGCGTCTCGCGCGCATGATGCTCAGCTTATTAAGAAAGTTGACGCTTA
CCTTCCTGAATATGATACCGATGGTCTTGAAATTAAGATCCTTGCTCCTTTAGAAGCAACTCAGTACTCACTGGTTCGTA
TCAAAGAAGGCCTAGATACTATTTCGGTTACAGGTAACGTATTACGTGATTACCTAACGGATTTGTTCCCGATTCTAGAG
CTTGGTACGTCAGCTAAAATGCTATCGATTGTTCCACTTATGAACGGTGGCGGCCTGTTTGAAACAGGTGCTGGCGGTTC
TGCGCCTAAGCATGTTCAACAAGTAGAGAAAGAAAACCACCTGCGTTGGGACTCTCTTGGTGAGTTCTTGGCACTAGCGG
CATCTCTAGAGCACCTAAGCGTAGTAACGGGGAATGCTAAGGCACAAGTTCTCGCTGACGCGCTTGATAAAGCGACGGGT
GAATTCCTAGATAACAACAAGTCTCCTTCACGTCGAGTGGGTGAGCTTGATAACCGTGGTAGCCACTACTACCTTGCAGC
ATACTGGGCGAAAGCGCTGGCTGAGCAAACGGTTGACGCTGACCTTGCTGCTGAGTTCGCAGGTGTTGCAACTCAATTGG
CTGAAAGTGAAGAAGCTATTGTTGCTGAGCTGAATAACGCTCAAGGTCCAGCTGGCGACTTAGGCGGTTATTACCTACTT
GATGATGCATTGGTTTCATCACTAATGCGCCCAAGCTCAACGCTAAACGCATTTATTGACGCATAG

Upstream 100 bases:

>100_bases
ACTATCGAGTAAGCAGTTTTCACTCTCAGAGTGGCTTACTGGTCAATTTATAACACTCTCACTGCTTTAAGTGAGCTTGT
AAGAACTATAGGGAAATTTC

Downstream 100 bases:

>100_bases
TGATTGGACTCATCGTTAGTAAGTCATGAACATGATTTACTAACGAGTTGCTTGGTCTGGCAGTTAAGTCACAGATAAAG
TCAAAACGAAAGACGCTTTA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH-II; IDP-2; NADP+-specific ICDH 2; Oxalosuccinate decarboxylase 2 [H]

Number of amino acids: Translated: 741; Mature: 740

Protein sequence:

>741_residues
MPTEKPTIIYTITDEAPALATYSLLPIIQSFTASSGINVDTRDISLAGRIIANFPDYLNEEQRIGDALAELGELAKTPEA
NIIKLPNISASVPQLQATIKELQSKGYALPNYPEEANTDEEKAVKATYDKIKGSAVNPVLREGNSDRRAPLSVKNYAKKN
PHSMGAWSADSKSHVSSMDDKDFFGSEKSVTIEGATEVSIEFVGKDGAKKTLKPAFALQDKEIIDASVMNKAALVAFFEK
EIASAKEQGVLLSLHMKATMMKVSDPVIFGHAVKVYYKDVFAKHGQLFEELGVDVNNGIGDVYAKIAALPQEQKEAIEAD
LQAVYETQPPLAMVDSDRGITNLHVPSDIIVDASMPAMLRSSGQMWDPEGKQKDTKAMIPDRSYASIYQAVIDFCKENGA
FDPTTMGSVPNVGLMAQKAEEYGSHDKTFILEAAGQVQVVDASGVVLLEQDVEEGDIFRMCQVKDAPIQDWVKLAVTRAR
ASGVPAVFWLDASRAHDAQLIKKVDAYLPEYDTDGLEIKILAPLEATQYSLVRIKEGLDTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKENHLRWDSLGEFLALAASLEHLSVVTGNAKAQVLADALDKATG
EFLDNNKSPSRRVGELDNRGSHYYLAAYWAKALAEQTVDADLAAEFAGVATQLAESEEAIVAELNNAQGPAGDLGGYYLL
DDALVSSLMRPSSTLNAFIDA

Sequences:

>Translated_741_residues
MPTEKPTIIYTITDEAPALATYSLLPIIQSFTASSGINVDTRDISLAGRIIANFPDYLNEEQRIGDALAELGELAKTPEA
NIIKLPNISASVPQLQATIKELQSKGYALPNYPEEANTDEEKAVKATYDKIKGSAVNPVLREGNSDRRAPLSVKNYAKKN
PHSMGAWSADSKSHVSSMDDKDFFGSEKSVTIEGATEVSIEFVGKDGAKKTLKPAFALQDKEIIDASVMNKAALVAFFEK
EIASAKEQGVLLSLHMKATMMKVSDPVIFGHAVKVYYKDVFAKHGQLFEELGVDVNNGIGDVYAKIAALPQEQKEAIEAD
LQAVYETQPPLAMVDSDRGITNLHVPSDIIVDASMPAMLRSSGQMWDPEGKQKDTKAMIPDRSYASIYQAVIDFCKENGA
FDPTTMGSVPNVGLMAQKAEEYGSHDKTFILEAAGQVQVVDASGVVLLEQDVEEGDIFRMCQVKDAPIQDWVKLAVTRAR
ASGVPAVFWLDASRAHDAQLIKKVDAYLPEYDTDGLEIKILAPLEATQYSLVRIKEGLDTISVTGNVLRDYLTDLFPILE
LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKENHLRWDSLGEFLALAASLEHLSVVTGNAKAQVLADALDKATG
EFLDNNKSPSRRVGELDNRGSHYYLAAYWAKALAEQTVDADLAAEFAGVATQLAESEEAIVAELNNAQGPAGDLGGYYLL
DDALVSSLMRPSSTLNAFIDA
>Mature_740_residues
PTEKPTIIYTITDEAPALATYSLLPIIQSFTASSGINVDTRDISLAGRIIANFPDYLNEEQRIGDALAELGELAKTPEAN
IIKLPNISASVPQLQATIKELQSKGYALPNYPEEANTDEEKAVKATYDKIKGSAVNPVLREGNSDRRAPLSVKNYAKKNP
HSMGAWSADSKSHVSSMDDKDFFGSEKSVTIEGATEVSIEFVGKDGAKKTLKPAFALQDKEIIDASVMNKAALVAFFEKE
IASAKEQGVLLSLHMKATMMKVSDPVIFGHAVKVYYKDVFAKHGQLFEELGVDVNNGIGDVYAKIAALPQEQKEAIEADL
QAVYETQPPLAMVDSDRGITNLHVPSDIIVDASMPAMLRSSGQMWDPEGKQKDTKAMIPDRSYASIYQAVIDFCKENGAF
DPTTMGSVPNVGLMAQKAEEYGSHDKTFILEAAGQVQVVDASGVVLLEQDVEEGDIFRMCQVKDAPIQDWVKLAVTRARA
SGVPAVFWLDASRAHDAQLIKKVDAYLPEYDTDGLEIKILAPLEATQYSLVRIKEGLDTISVTGNVLRDYLTDLFPILEL
GTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKENHLRWDSLGEFLALAASLEHLSVVTGNAKAQVLADALDKATGE
FLDNNKSPSRRVGELDNRGSHYYLAAYWAKALAEQTVDADLAAEFAGVATQLAESEEAIVAELNNAQGPAGDLGGYYLLD
DALVSSLMRPSSTLNAFIDA

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 80115; Mature: 79984

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTEKPTIIYTITDEAPALATYSLLPIIQSFTASSGINVDTRDISLAGRIIANFPDYLNE
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHCCH
EQRIGDALAELGELAKTPEANIIKLPNISASVPQLQATIKELQSKGYALPNYPEEANTDE
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAVKATYDKIKGSAVNPVLREGNSDRRAPLSVKNYAKKNPHSMGAWSADSKSHVSSMDD
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCC
KDFFGSEKSVTIEGATEVSIEFVGKDGAKKTLKPAFALQDKEIIDASVMNKAALVAFFEK
HHHCCCCCEEEEECCCEEEEEEECCCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
EIASAKEQGVLLSLHMKATMMKVSDPVIFGHAVKVYYKDVFAKHGQLFEELGVDVNNGIG
HHHHHHHCCEEEEEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYAKIAALPQEQKEAIEADLQAVYETQPPLAMVDSDRGITNLHVPSDIIVDASMPAMLR
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCEEECCCCCHHHH
SSGQMWDPEGKQKDTKAMIPDRSYASIYQAVIDFCKENGAFDPTTMGSVPNVGLMAQKAE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFILEAAGQVQVVDASGVVLLEQDVEEGDIFRMCQVKDAPIQDWVKLAVTRAR
HHCCCCCEEEEECCCEEEEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ASGVPAVFWLDASRAHDAQLIKKVDAYLPEYDTDGLEIKILAPLEATQYSLVRIKEGLDT
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKENH
EEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALAASLEHLSVVTGNAKAQVLADALDKATGEFLDNNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
SHYYLAAYWAKALAEQTVDADLAAEFAGVATQLAESEEAIVAELNNAQGPAGDLGGYYLL
CEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEH
DDALVSSLMRPSSTLNAFIDA
HHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure 
PTEKPTIIYTITDEAPALATYSLLPIIQSFTASSGINVDTRDISLAGRIIANFPDYLNE
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHCCH
EQRIGDALAELGELAKTPEANIIKLPNISASVPQLQATIKELQSKGYALPNYPEEANTDE
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKAVKATYDKIKGSAVNPVLREGNSDRRAPLSVKNYAKKNPHSMGAWSADSKSHVSSMDD
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCC
KDFFGSEKSVTIEGATEVSIEFVGKDGAKKTLKPAFALQDKEIIDASVMNKAALVAFFEK
HHHCCCCCEEEEECCCEEEEEEECCCCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHH
EIASAKEQGVLLSLHMKATMMKVSDPVIFGHAVKVYYKDVFAKHGQLFEELGVDVNNGIG
HHHHHHHCCEEEEEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DVYAKIAALPQEQKEAIEADLQAVYETQPPLAMVDSDRGITNLHVPSDIIVDASMPAMLR
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCEEECCCCCHHHH
SSGQMWDPEGKQKDTKAMIPDRSYASIYQAVIDFCKENGAFDPTTMGSVPNVGLMAQKAE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFILEAAGQVQVVDASGVVLLEQDVEEGDIFRMCQVKDAPIQDWVKLAVTRAR
HHCCCCCEEEEECCCEEEEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
ASGVPAVFWLDASRAHDAQLIKKVDAYLPEYDTDGLEIKILAPLEATQYSLVRIKEGLDT
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCE
ISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQVEKENH
EEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCC
LRWDSLGEFLALAASLEHLSVVTGNAKAQVLADALDKATGEFLDNNKSPSRRVGELDNRG
CCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCC
SHYYLAAYWAKALAEQTVDADLAAEFAGVATQLAESEEAIVAELNNAQGPAGDLGGYYLL
CEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEH
DDALVSSLMRPSSTLNAFIDA
HHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226630; 1295895 [H]