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The map label for this gene is hutH [H]

Identifier: 218708780

GI number: 218708780

Start: 802089

End: 803636

Strand: Reverse

Name: hutH [H]

Synonym: VS_0779

Alternate gene names: 218708780

Gene position: 803636-802089 (Counterclockwise)

Preceding gene: 218708781

Following gene: 218708779

Centisome position: 24.36

GC content: 48.32

Gene sequence:

>1548_bases
ATGACGAAAAAAAATCCAAATAGCATCACCTTTGGTGCCGAACGCCTCACGATTGAGGATGTTGTCGCTATTTCACAAGG
CGCAAAAGCCTCGATGAACTCAAGTAATGAGTTCACATCAAAGATCGACCGCGGTGTCGCTTTTTTAGAACGCCTATTGA
AAGAAGAAGGCGTGATCTATGGTGTGACAACGGGCTACGGTGACTCATGTACCGTTGCGATTCCGCCAAACCTTGTTGAT
GAGCTACCACTGCATCTAACGCGCTTTCATGGCTGTGGTTTAGGCGAAATACTGTCTCACGAACAATCTCGTGCAGTATT
AGCAACGCGCCTTTGTTCATTGTCACAAGGTGTCTCTGGTGTGACTCACGATTTGCTCAACCAGATCGTCACTCTGATCA
ACCAAGATATCTCACCGCGTATTCCTCAAGAAGGATCGGTTGGTGCCAGTGGTGATTTAACGCCGCTGTCTTATCTGGCA
GCTGCACTGATTGGTGAGCGCGATGTTATCTACAAAGGTGAAGTTCGCCCAACCAGTGACGTCTACAAAGAGCTAGGTAT
CAGCCCTATCAAGCTTAAGCCAAAAGAAGGCTTAGCATTGATGAATGGCACATCAGTAATGACGGCTTTGGCTTGTATCG
CCTACAAACGTGCGGAATATCTAGCGCAACTATCAACTAAGATCACAGCTATGGTATCTGTGGGTATGCAAGGCAACGAC
TTCCACTTCGATGAAGCGCTATTTGCTGTTAAACCACACCCAGGCCAGCAGCAAGTTGCGGCATGGCTACGTGATGACTT
ACAAGCAGATCGCCCGCCACGCAACAGTGATCGCTTACAAGATCGTTACTCACTGCGTTGTGCTCCACATGTGATTGGTG
TGGTTCAAGACTCTCTGCCTTGGCTACGCCAAATGATTGAGAACGAGCTCAACAGCGCTAACGATAACCCAATTATCGAT
GGCGACAATGAGCGCGTACTGCACGGTGGACACTTCTACGGTGGTCATATCGCAATGGCAATGGATACACTAAAAACAGC
GGTAGCCAACCTTGCAGATCTGCTTGATCGCCAAATGGCGCAGCTAATGGACTACAAGTTCAACAACGGCTTGCCATTTA
ACCTAACAGGCGCAGAAGGTGAACGTAAGCCGATTAACCATGGCTTCAAAGCGGTACAGATCGGCGTTTCAGCTTGGACA
GCAGAAGCATTGAAACACACCATGCCAGCAAGCGTGTTCTCTCGTTCAACCGAGTGTCACAACCAAGACAAAGTCAGCAT
GGGCACCATTGCAGCTCGTGACTGCTTACGCGTTCTTGAACTGACTGAACAAGTAGCGGCAGCATCACTTCTAGCGGGGA
CACAAGCGCTTGAACTTCGTAAACGCCACAATGAGCTTGATGAGCACCACATGAGTGAGAACCTCAAGCACATTCGCGAC
GAAGTACTCAAAGAGTTTGAATTTATCGTAGAAGATCGACCACTTGAAGGCGATCTACGTCACTTCATTGCTCGTATTCA
AAGTCAACACTGGTCACTTTACTCCTAG

Upstream 100 bases:

>100_bases
CAAGTCGTGCAGAAATACGCAGACCGACTTCAGCACTACACACTGAAAGCACCGCTTCAGTGGTACAACTTTTTTAACTT
TTGGACATTGAGCAAGCACC

Downstream 100 bases:

>100_bases
AGTAGCTAACCCTTTACGCAATATTGTTGAGAGCGATTTATGTCTGAAATCCTTCATCCATTAAAATCAGAGGTTACTTT
AGTAACCTCATTCCAAGATG

Product: histidine ammonia-lyase protein

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTKKNPNSITFGAERLTIEDVVAISQGAKASMNSSNEFTSKIDRGVAFLERLLKEEGVIYGVTTGYGDSCTVAIPPNLVD
ELPLHLTRFHGCGLGEILSHEQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINQDISPRIPQEGSVGASGDLTPLSYLA
AALIGERDVIYKGEVRPTSDVYKELGISPIKLKPKEGLALMNGTSVMTALACIAYKRAEYLAQLSTKITAMVSVGMQGND
FHFDEALFAVKPHPGQQQVAAWLRDDLQADRPPRNSDRLQDRYSLRCAPHVIGVVQDSLPWLRQMIENELNSANDNPIID
GDNERVLHGGHFYGGHIAMAMDTLKTAVANLADLLDRQMAQLMDYKFNNGLPFNLTGAEGERKPINHGFKAVQIGVSAWT
AEALKHTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAASLLAGTQALELRKRHNELDEHHMSENLKHIRD
EVLKEFEFIVEDRPLEGDLRHFIARIQSQHWSLYS

Sequences:

>Translated_515_residues
MTKKNPNSITFGAERLTIEDVVAISQGAKASMNSSNEFTSKIDRGVAFLERLLKEEGVIYGVTTGYGDSCTVAIPPNLVD
ELPLHLTRFHGCGLGEILSHEQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINQDISPRIPQEGSVGASGDLTPLSYLA
AALIGERDVIYKGEVRPTSDVYKELGISPIKLKPKEGLALMNGTSVMTALACIAYKRAEYLAQLSTKITAMVSVGMQGND
FHFDEALFAVKPHPGQQQVAAWLRDDLQADRPPRNSDRLQDRYSLRCAPHVIGVVQDSLPWLRQMIENELNSANDNPIID
GDNERVLHGGHFYGGHIAMAMDTLKTAVANLADLLDRQMAQLMDYKFNNGLPFNLTGAEGERKPINHGFKAVQIGVSAWT
AEALKHTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAASLLAGTQALELRKRHNELDEHHMSENLKHIRD
EVLKEFEFIVEDRPLEGDLRHFIARIQSQHWSLYS
>Mature_514_residues
TKKNPNSITFGAERLTIEDVVAISQGAKASMNSSNEFTSKIDRGVAFLERLLKEEGVIYGVTTGYGDSCTVAIPPNLVDE
LPLHLTRFHGCGLGEILSHEQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINQDISPRIPQEGSVGASGDLTPLSYLAA
ALIGERDVIYKGEVRPTSDVYKELGISPIKLKPKEGLALMNGTSVMTALACIAYKRAEYLAQLSTKITAMVSVGMQGNDF
HFDEALFAVKPHPGQQQVAAWLRDDLQADRPPRNSDRLQDRYSLRCAPHVIGVVQDSLPWLRQMIENELNSANDNPIIDG
DNERVLHGGHFYGGHIAMAMDTLKTAVANLADLLDRQMAQLMDYKFNNGLPFNLTGAEGERKPINHGFKAVQIGVSAWTA
EALKHTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAASLLAGTQALELRKRHNELDEHHMSENLKHIRDE
VLKEFEFIVEDRPLEGDLRHFIARIQSQHWSLYS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=460, Percent_Identity=37.1739130434783, Blast_Score=291, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17567831, Length=506, Percent_Identity=35.3754940711462, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56793; Mature: 56662

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKNPNSITFGAERLTIEDVVAISQGAKASMNSSNEFTSKIDRGVAFLERLLKEEGVIY
CCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
GVTTGYGDSCTVAIPPNLVDELPLHLTRFHGCGLGEILSHEQSRAVLATRLCSLSQGVSG
EEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCH
VTHDLLNQIVTLINQDISPRIPQEGSVGASGDLTPLSYLAAALIGERDVIYKGEVRPTSD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHH
VYKELGISPIKLKPKEGLALMNGTSVMTALACIAYKRAEYLAQLSTKITAMVSVGMQGND
HHHHHCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
FHFDEALFAVKPHPGQQQVAAWLRDDLQADRPPRNSDRLQDRYSLRCAPHVIGVVQDSLP
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WLRQMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDTLKTAVANLADLLDRQMA
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHH
QLMDYKFNNGLPFNLTGAEGERKPINHGFKAVQIGVSAWTAEALKHTMPASVFSRSTECH
HHHCCCCCCCCCEEEECCCCCCCCHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHCCHHHC
NQDKVSMGTIAARDCLRVLELTEQVAAASLLAGTQALELRKRHNELDEHHMSENLKHIRD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVLKEFEFIVEDRPLEGDLRHFIARIQSQHWSLYS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKKNPNSITFGAERLTIEDVVAISQGAKASMNSSNEFTSKIDRGVAFLERLLKEEGVIY
CCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
GVTTGYGDSCTVAIPPNLVDELPLHLTRFHGCGLGEILSHEQSRAVLATRLCSLSQGVSG
EEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCH
VTHDLLNQIVTLINQDISPRIPQEGSVGASGDLTPLSYLAAALIGERDVIYKGEVRPTSD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHH
VYKELGISPIKLKPKEGLALMNGTSVMTALACIAYKRAEYLAQLSTKITAMVSVGMQGND
HHHHHCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
FHFDEALFAVKPHPGQQQVAAWLRDDLQADRPPRNSDRLQDRYSLRCAPHVIGVVQDSLP
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WLRQMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDTLKTAVANLADLLDRQMA
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHH
QLMDYKFNNGLPFNLTGAEGERKPINHGFKAVQIGVSAWTAEALKHTMPASVFSRSTECH
HHHCCCCCCCCCEEEECCCCCCCCHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHCCHHHC
NQDKVSMGTIAARDCLRVLELTEQVAAASLLAGTQALELRKRHNELDEHHMSENLKHIRD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVLKEFEFIVEDRPLEGDLRHFIARIQSQHWSLYS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA