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The map label for this gene is lspA [H]

Identifier: 218708571

GI number: 218708571

Start: 558763

End: 559263

Strand: Direct

Name: lspA [H]

Synonym: VS_0537

Alternate gene names: 218708571

Gene position: 558763-559263 (Clockwise)

Preceding gene: 218708570

Following gene: 218708572

Centisome position: 16.94

GC content: 45.31

Gene sequence:

>501_bases
ATGAGTGAAGTTTCGTTAAAACAATCTGGTGTGCGTTGGTTATGGCTGGCTCTGTTGGTCTTCCTTGCCGATATTGGCAT
CAAACTGTTCGTCATGGACAATATGGGTTATGGCTGGGCAAACCGTATTGAGGTGTTGCCATTCTTTAACTTTTTGTATG
TCCATAACTATGGTGCAGCATTTAGCTTTCTGAGCGATCAGAGTGGCTGGCAGCGTTGGTTATTTACGGGTATCGCCTTT
GCGGTAACGGGCATGCTGACATACTGGATGAGCAAACTACCTGCGGCAGAGAAGTGGAATAACATTGCTTATGCGATCAT
CATTGGTGGTGCTGTTGGTAACGTATTTGACCGAGTAGTACACGGCTTTGTTGTCGATTACTTAGATTTCTACTGGGGTA
CTTACCATTGGCCTGCGTTTAACTTAGCGGATATGGGGATCTGTATCGGTGCTGCGATGATCATCCTAGATGGTTTCCGC
AAGAAAGATGAAAGCAAATAG

Upstream 100 bases:

>100_bases
TTTTTAATTATAGGAAATGTGTTTAACCGAGTTGAGTGCTCATCATCCCTTAAACAGGAAGATTAAATGGGTACTGGCTT
CGTAAATACTAGGAATAGAA

Downstream 100 bases:

>100_bases
GCGACTCAGGTATTAATGAGTATTAACTAAATCGCTTTGAATTAGATTGCCCTAAAGTCAGTCTATGACTCACAGAATGG
AATAGCCCTAAGCGCTGTCG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSEVSLKQSGVRWLWLALLVFLADIGIKLFVMDNMGYGWANRIEVLPFFNFLYVHNYGAAFSFLSDQSGWQRWLFTGIAF
AVTGMLTYWMSKLPAAEKWNNIAYAIIIGGAVGNVFDRVVHGFVVDYLDFYWGTYHWPAFNLADMGICIGAAMIILDGFR
KKDESK

Sequences:

>Translated_166_residues
MSEVSLKQSGVRWLWLALLVFLADIGIKLFVMDNMGYGWANRIEVLPFFNFLYVHNYGAAFSFLSDQSGWQRWLFTGIAF
AVTGMLTYWMSKLPAAEKWNNIAYAIIIGGAVGNVFDRVVHGFVVDYLDFYWGTYHWPAFNLADMGICIGAAMIILDGFR
KKDESK
>Mature_165_residues
SEVSLKQSGVRWLWLALLVFLADIGIKLFVMDNMGYGWANRIEVLPFFNFLYVHNYGAAFSFLSDQSGWQRWLFTGIAFA
VTGMLTYWMSKLPAAEKWNNIAYAIIIGGAVGNVFDRVVHGFVVDYLDFYWGTYHWPAFNLADMGICIGAAMIILDGFRK
KDESK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=166, Percent_Identity=50, Blast_Score=171, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18920; Mature: 18789

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVSLKQSGVRWLWLALLVFLADIGIKLFVMDNMGYGWANRIEVLPFFNFLYVHNYGAA
CCCCCCHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHH
FSFLSDQSGWQRWLFTGIAFAVTGMLTYWMSKLPAAEKWNNIAYAIIIGGAVGNVFDRVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEECCHHHHHHHHHH
HGFVVDYLDFYWGTYHWPAFNLADMGICIGAAMIILDGFRKKDESK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEVSLKQSGVRWLWLALLVFLADIGIKLFVMDNMGYGWANRIEVLPFFNFLYVHNYGAA
CCCCCHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHH
FSFLSDQSGWQRWLFTGIAFAVTGMLTYWMSKLPAAEKWNNIAYAIIIGGAVGNVFDRVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEECCHHHHHHHHHH
HGFVVDYLDFYWGTYHWPAFNLADMGICIGAAMIILDGFRKKDESK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]