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The map label for this gene is obgE

Identifier: 218708403

GI number: 218708403

Start: 363489

End: 364661

Strand: Direct

Name: obgE

Synonym: VS_0363

Alternate gene names: 218708403

Gene position: 363489-364661 (Clockwise)

Preceding gene: 218708402

Following gene: 218708404

Centisome position: 11.02

GC content: 44.25

Gene sequence:

>1173_bases
ATGAAATTCGTTGATGAAGCATCAGTAAAAATAGAAGCCGGTGATGGCGGTAATGGTACAGTAAGCTTTTGGCGCGAAAA
ATTCGTCGCTAAAGGTGGTCCTGATGGCGGTGATGGCGGTGATGGTGGTGATGTTTACATTCAAGCGGATGAGAACTTAA
ACACACTGATCGATTACCGTTTCCAACGTTTTTACAATGCAGAGCGTGGCGAAAATGGCCGCGGTGGTAACTGTACTGGT
AAACGTGGTAAAGATATGACCATGAAAGTACCTGTAGGTACTCGTGCTGTTGATATCCACACTAATGAAATCGTTGCTGA
AGTTGCTGAACATGGCAAAAAAGTCATGGTTGGTAAAGGTGGTTGGCACGGTCTTGGTAACACGCGTTTTAAGTCGTCGG
TTAACCGTGCTCCTCGTCAAAAGACAATGGGTACTAAAGGTGAAGTTCGCGAACTGCGTTTAGAGCTTCTTCTATTAGCG
GATGTTGGTATGCTTGGCTTGCCAAACGCTGGTAAATCTACTTTTATTCGCTCAGTATCTGCTGCGAAACCGAAAGTTGC
TGATTACCCGTTTACTACGCTAATCCCTAGCTTAGGTGTGGTAAGTGTTGTCCCTGAAAAAAGCTTCGTTGTTGCTGATA
TCCCGGGTCTAATTGAAGGTGCGGCTGATGGCGCTGGTCTGGGTATTCGTTTCTTGAAGCACCTTGAGCGTTGTCGTGTT
CTTCTGCACATGATCGATATTTTGCCGATTGATGGTTCTGATCCTATTCAGAATGCACTGACGATCATTGACGAGCTTGA
GCAGTACAGCGAAAAAGTAGCACAGAAACCTCGCTGGTTAGTATTCAACAAAGTTGATCTAATGCCTGAAGAAGAAGCTG
ACGAAAAGATTCAAGAAATCGTCGAAGCTTTAGGTTGGGAAGGCGAGTACTTCAAGATCTCTGCTGTAAACAAGATCGGT
ACCAAAGATCTTTGCTTTAAACTGGGTGAGTTCATGGAGAACCTACCTCGTGAAGTTGAAGCAATTGAAGAAGAAGAAAA
AGTTAACTTTATGTGGGATGACTACCATAAAGATGCGATGGCCGGTAAGAATGTCGTTACTGAAGATGACGACGACTGGG
ATGATTGGGATGACGAAGAAGATGACGGTCATGTTATCTATGTTCGTGATTAA

Upstream 100 bases:

>100_bases
GATCGATCTAGATCTTAGGTGATCGATCTAAACACGGATCTGCTAGAATTTATATCACTCCTTGATGAGTGGTAACGCAA
CGTAAGTGCGGAGTTAAAAA

Downstream 100 bases:

>100_bases
TAATCCTCGTAGTTTCTTATAAGCACTTTGGTCGCTTTTTCTAAGATACGCTGATAGTTTTATTAAACCGCAATGAAAAT
TGCGGTTTTTTTGTATCTAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEASVKIEAGDGGNGTVSFWREKFVAKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYNAERGENGRGGNCTG
KRGKDMTMKVPVGTRAVDIHTNEIVAEVAEHGKKVMVGKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRSVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDILPIDGSDPIQNALTIIDELEQYSEKVAQKPRWLVFNKVDLMPEEEADEKIQEIVEALGWEGEYFKISAVNKIG
TKDLCFKLGEFMENLPREVEAIEEEEKVNFMWDDYHKDAMAGKNVVTEDDDDWDDWDDEEDDGHVIYVRD

Sequences:

>Translated_390_residues
MKFVDEASVKIEAGDGGNGTVSFWREKFVAKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYNAERGENGRGGNCTG
KRGKDMTMKVPVGTRAVDIHTNEIVAEVAEHGKKVMVGKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRSVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDILPIDGSDPIQNALTIIDELEQYSEKVAQKPRWLVFNKVDLMPEEEADEKIQEIVEALGWEGEYFKISAVNKIG
TKDLCFKLGEFMENLPREVEAIEEEEKVNFMWDDYHKDAMAGKNVVTEDDDDWDDWDDEEDDGHVIYVRD
>Mature_390_residues
MKFVDEASVKIEAGDGGNGTVSFWREKFVAKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYNAERGENGRGGNCTG
KRGKDMTMKVPVGTRAVDIHTNEIVAEVAEHGKKVMVGKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEVRELRLELLLLA
DVGMLGLPNAGKSTFIRSVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
LLHMIDILPIDGSDPIQNALTIIDELEQYSEKVAQKPRWLVFNKVDLMPEEEADEKIQEIVEALGWEGEYFKISAVNKIG
TKDLCFKLGEFMENLPREVEAIEEEEKVNFMWDDYHKDAMAGKNVVTEDDDDWDDWDDEEDDGHVIYVRD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=307, Percent_Identity=40.3908794788274, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI111955139, Length=311, Percent_Identity=35.048231511254, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI111955063, Length=167, Percent_Identity=39.5209580838323, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=33.8582677165354, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=361, Percent_Identity=69.5290858725762, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=28.6821705426357, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=331, Percent_Identity=38.6706948640483, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=310, Percent_Identity=31.2903225806452, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555344, Length=143, Percent_Identity=30.0699300699301, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=166, Percent_Identity=39.1566265060241, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=30.1587301587302, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=34.4051446945338, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI20129375, Length=335, Percent_Identity=35.8208955223881, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24640873, Length=129, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640877, Length=129, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640875, Length=129, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_VIBSL (B7VID5)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416024.1
- ProteinModelPortal:   B7VID5
- SMR:   B7VID5
- GeneID:   7160000
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0363
- HOGENOM:   HBG716038
- OMA:   YIQADEN
- ProtClustDB:   PRK12298
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 43197; Mature: 43197

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEASVKIEAGDGGNGTVSFWREKFVAKGGPDGGDGGDGGDVYIQADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FQRFYNAERGENGRGGNCTGKRGKDMTMKVPVGTRAVDIHTNEIVAEVAEHGKKVMVGKG
HHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECHHHHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTMGTKGEVRELRLELLLLADVGMLGLPNAGKSTFIRSVS
CCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHMIDILPIDGSDPIQNALTIIDELEQYSEKVAQKPRWLVFNKVDLMPEEEADEKIQEI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
VEALGWEGEYFKISAVNKIGTKDLCFKLGEFMENLPREVEAIEEEEKVNFMWDDYHKDAM
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHH
AGKNVVTEDDDDWDDWDDEEDDGHVIYVRD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKFVDEASVKIEAGDGGNGTVSFWREKFVAKGGPDGGDGGDGGDVYIQADENLNTLIDYR
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FQRFYNAERGENGRGGNCTGKRGKDMTMKVPVGTRAVDIHTNEIVAEVAEHGKKVMVGKG
HHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECHHHHHHHHHHCCCEEEEECC
GWHGLGNTRFKSSVNRAPRQKTMGTKGEVRELRLELLLLADVGMLGLPNAGKSTFIRSVS
CCCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHH
LLHMIDILPIDGSDPIQNALTIIDELEQYSEKVAQKPRWLVFNKVDLMPEEEADEKIQEI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
VEALGWEGEYFKISAVNKIGTKDLCFKLGEFMENLPREVEAIEEEEKVNFMWDDYHKDAM
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHH
AGKNVVTEDDDDWDDWDDEEDDGHVIYVRD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA