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The map label for this gene is rnr [H]

Identifier: 218708331

GI number: 218708331

Start: 271566

End: 274067

Strand: Direct

Name: rnr [H]

Synonym: VS_0278

Alternate gene names: 218708331

Gene position: 271566-274067 (Clockwise)

Preceding gene: 218708329

Following gene: 218708332

Centisome position: 8.23

GC content: 46.84

Gene sequence:

>2502_bases
ATGTCAAAAAACACACCAATGTCAGAAAACACGACAGCGACAACCACTGTTGATCCTTTTGCCGACCGAGAGTCGAAAAA
TTACGAAAACCCAGTACCAAGCCGTGAGTTCATTATTTCGTTTCTAACAGACGCGAATATTCCTATGAACCGCAACGATC
TATTCGAAGCTTTGGGTTTGGCTGGAGAGGAACAATATGAAGGGCTGCGTCGTCGTTTACGTGCAATGGAACGTGATGGA
CAGCTTATCTTTACCCGTCGTCAGTGTTACGCATTGCCTGAGAAGATGGAATTGATTAAAGGCTTTGTGATTGGTCATAA
AGACGGTCATGGTTGGGTACGCCCAGACGGCAGTGTGGGTAAAGACAATGATATCGTGCTGCCGCATCATCAGATGAAAA
CCATCATGCACGGCGATTACGTATTGGTTCAGCCTACTGACAACAGTAAGCGTGGCCGTCGTGAAGGCCGTTTGGTTCGT
GTGCTTGAAGAGCGTAAAACGCCACTTGTTGGTCGCTTCTTCCTAGAGTACGGCCATTCTTATGTGGTTGCTGATGATTC
GCGTATTAGTCACGACATCCAGATCCCAACTGAGCATAAAGGCGGTGCTCGAATGGGTAATGTGGTTGTGATTGAAATTA
CGGACCGTGGTGGTCGTTCTCGTAACATGATGGGTAAAGTGACCGAAGTTCTTGGTGAGAATATGGCTCCGGGTATGGAA
ACGCAGATCGCGATCCGTACTCACCAGATCCCACAAGAGTGGCCTGAAGCCGTAGATAAGCAAATCGAAAATCTTGGTGA
GCATGTTCCTGAAGAAGCAAAAGAAGGACGTGTTGATCTGCGTAAATTGCCATTGGTGACTATCGATGGTGAAGATGCGC
GTGACTTCGATGATGCGGTTTACTGTGAAGCGAAGAAAGGCGGCGGCTGGCGCCTATGGGTAGCGATTGCTGACGTAAGT
TATTACGTTCGCCCAGAGACAGCGCTAGACAAAGAAGCGATTAACCGTGGTAACTCGGTATACTTCCCGTCACAAGTTGT
CCCGATGCTGCCAGAAGTACTTTCAAATGGTTTGTGTTCATTGAATCCTCAAGTCGACCGTTTGTGTATGGTGTGTGAGA
TGACTATCTCAGACAAAGGTAAACTGTCAGGCTACAAGCACTACGAAGCAGTCATGAATTCCCATGCTCGTCTTACTTAT
AACAAAGTAGGCGCGATCTTAGATGGCAATGAAGAATTACGTGAACGTTACGAACCAGAAGTACCACATCTTGAAGAGCT
TCATAAGATGTACAAGGTGCTTAAGAAAACGCGTGACGAACGTGGTGCGATTGAATTTGAAACGGTAGAAACTAAGTTTA
TCTTCAATGCGGATCGTAAGATTGACCGTATTGAGCCAGTCATCCGTAACGATGCACACAAGATCATCGAAGAATGTATG
ATTCTTGCGAATATCGCATCGGCATCTTACGTAGAAAAAGCGAAAGAGCCGGCTCTATACCGTGTTCACGATACTCCGGG
TGAAGAGCGCTTAATGGGCTTCAAAAGCTTCTTAAGTGAACTAGGCTTAACGCTGGAGGGTGGCCTGTCGCCATCTCCGG
TAGACTATGCACAACTGATGCAGCAGATTAACGAACGTGAAGATCGTGAATTAATCCAAACTATGCTGTTGCGCTCAATG
AAACAAGCGGTATACAACGCGGACAACGCGGGTCACTTTGGTCTAGCTCTTAAGCGCTATGCTCACTTTACCTCGCCAAT
TCGTCGTTACCCAGATTTACTATTGCACCGTGCAATTAAGTACCTTATTGCGAAAGAAGAAGGTCGTAACAGCGAGCGTT
GGACGCCAACCGGTGGTTACCACTACACTTTCGATGATATGGACTTCTACGGCGAACAGTGTTCAATGACTGAGCGTCGT
GCTGATGATGCTACACGTGAAGTGAACGACTGGCTGAAATGTGAATACATGCAAGACCATGTTGGCGAAGTGATGGATGG
CGTGATTGCCAACGTGACTGGCTTCGGTTTCTTTGTGCGTCTAACGGAACTGCACATCGATGGTCTGGTACATATTTCTG
CGCTAGCGAATGACTACTACCAATTTGATGCTGTTGGTCAGCGTCTAGTGGGTGAAAGCTCAGGTAATATCTACCGCTTG
GGTGATTCGGTTAAAGTGAAGGTTTCTGCGGTTAACTTAGAAACTCGTCAAATCGACTTTGATTTAGAAGACACCGATCG
TCAGCCGCGTGGTAAAGGTAAAACAGCCAAGAAGCGTGCTGCTGAAGCGATGAAAAAGGCGAAAAGCAAGAAGCGTTCAG
CGGTGAAGAGCAATAAGCCGGGTGTACCTGCAACGCCTTTAGTTGAACCAACTAAGCGACCTGATGGAAGTAGCGAAAGT
TCATCTAAGAAGAAAAAGTCAGCGAATAAAACTGGTGCTGCTAAAGCTCGTGCGAAGAAAAAGCGCGCAGCAAGCCGTAA
GCCAAAGGCTGATAAGTCTTAA

Upstream 100 bases:

>100_bases
CTTAGGTTATTTTAGGCTTTTCCAAAGCATATCTGTAGCTTACCTCTAGCATCAGATATACTAGGGGTAATATACCTTCC
TTGCTTAAGCAGGCCCGCCT

Downstream 100 bases:

>100_bases
GCTATCGTCATTACAGTGACGAGTAGCGCTTAAACGTCTAACGAATTTAAATGCGAGAGTATCAGGCGGAAGATGCATGC
TCTCGAAATAAACAATACAG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 833; Mature: 832

Protein sequence:

>833_residues
MSKNTPMSENTTATTTVDPFADRESKNYENPVPSREFIISFLTDANIPMNRNDLFEALGLAGEEQYEGLRRRLRAMERDG
QLIFTRRQCYALPEKMELIKGFVIGHKDGHGWVRPDGSVGKDNDIVLPHHQMKTIMHGDYVLVQPTDNSKRGRREGRLVR
VLEERKTPLVGRFFLEYGHSYVVADDSRISHDIQIPTEHKGGARMGNVVVIEITDRGGRSRNMMGKVTEVLGENMAPGME
TQIAIRTHQIPQEWPEAVDKQIENLGEHVPEEAKEGRVDLRKLPLVTIDGEDARDFDDAVYCEAKKGGGWRLWVAIADVS
YYVRPETALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISDKGKLSGYKHYEAVMNSHARLTY
NKVGAILDGNEELRERYEPEVPHLEELHKMYKVLKKTRDERGAIEFETVETKFIFNADRKIDRIEPVIRNDAHKIIEECM
ILANIASASYVEKAKEPALYRVHDTPGEERLMGFKSFLSELGLTLEGGLSPSPVDYAQLMQQINEREDRELIQTMLLRSM
KQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEEGRNSERWTPTGGYHYTFDDMDFYGEQCSMTERR
ADDATREVNDWLKCEYMQDHVGEVMDGVIANVTGFGFFVRLTELHIDGLVHISALANDYYQFDAVGQRLVGESSGNIYRL
GDSVKVKVSAVNLETRQIDFDLEDTDRQPRGKGKTAKKRAAEAMKKAKSKKRSAVKSNKPGVPATPLVEPTKRPDGSSES
SSKKKKSANKTGAAKARAKKKRAASRKPKADKS

Sequences:

>Translated_833_residues
MSKNTPMSENTTATTTVDPFADRESKNYENPVPSREFIISFLTDANIPMNRNDLFEALGLAGEEQYEGLRRRLRAMERDG
QLIFTRRQCYALPEKMELIKGFVIGHKDGHGWVRPDGSVGKDNDIVLPHHQMKTIMHGDYVLVQPTDNSKRGRREGRLVR
VLEERKTPLVGRFFLEYGHSYVVADDSRISHDIQIPTEHKGGARMGNVVVIEITDRGGRSRNMMGKVTEVLGENMAPGME
TQIAIRTHQIPQEWPEAVDKQIENLGEHVPEEAKEGRVDLRKLPLVTIDGEDARDFDDAVYCEAKKGGGWRLWVAIADVS
YYVRPETALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISDKGKLSGYKHYEAVMNSHARLTY
NKVGAILDGNEELRERYEPEVPHLEELHKMYKVLKKTRDERGAIEFETVETKFIFNADRKIDRIEPVIRNDAHKIIEECM
ILANIASASYVEKAKEPALYRVHDTPGEERLMGFKSFLSELGLTLEGGLSPSPVDYAQLMQQINEREDRELIQTMLLRSM
KQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEEGRNSERWTPTGGYHYTFDDMDFYGEQCSMTERR
ADDATREVNDWLKCEYMQDHVGEVMDGVIANVTGFGFFVRLTELHIDGLVHISALANDYYQFDAVGQRLVGESSGNIYRL
GDSVKVKVSAVNLETRQIDFDLEDTDRQPRGKGKTAKKRAAEAMKKAKSKKRSAVKSNKPGVPATPLVEPTKRPDGSSES
SSKKKKSANKTGAAKARAKKKRAASRKPKADKS
>Mature_832_residues
SKNTPMSENTTATTTVDPFADRESKNYENPVPSREFIISFLTDANIPMNRNDLFEALGLAGEEQYEGLRRRLRAMERDGQ
LIFTRRQCYALPEKMELIKGFVIGHKDGHGWVRPDGSVGKDNDIVLPHHQMKTIMHGDYVLVQPTDNSKRGRREGRLVRV
LEERKTPLVGRFFLEYGHSYVVADDSRISHDIQIPTEHKGGARMGNVVVIEITDRGGRSRNMMGKVTEVLGENMAPGMET
QIAIRTHQIPQEWPEAVDKQIENLGEHVPEEAKEGRVDLRKLPLVTIDGEDARDFDDAVYCEAKKGGGWRLWVAIADVSY
YVRPETALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISDKGKLSGYKHYEAVMNSHARLTYN
KVGAILDGNEELRERYEPEVPHLEELHKMYKVLKKTRDERGAIEFETVETKFIFNADRKIDRIEPVIRNDAHKIIEECMI
LANIASASYVEKAKEPALYRVHDTPGEERLMGFKSFLSELGLTLEGGLSPSPVDYAQLMQQINEREDRELIQTMLLRSMK
QAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIKYLIAKEEGRNSERWTPTGGYHYTFDDMDFYGEQCSMTERRA
DDATREVNDWLKCEYMQDHVGEVMDGVIANVTGFGFFVRLTELHIDGLVHISALANDYYQFDAVGQRLVGESSGNIYRLG
DSVKVKVSAVNLETRQIDFDLEDTDRQPRGKGKTAKKRAAEAMKKAKSKKRSAVKSNKPGVPATPLVEPTKRPDGSSESS
SKKKKSANKTGAAKARAKKKRAASRKPKADKS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=472, Percent_Identity=29.4491525423729, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI190014625, Length=472, Percent_Identity=29.4491525423729, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI134288890, Length=540, Percent_Identity=26.6666666666667, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI219521928, Length=637, Percent_Identity=25.9026687598116, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI19115966, Length=512, Percent_Identity=27.34375, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI87082383, Length=741, Percent_Identity=65.1821862348178, Blast_Score=1024, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=669, Percent_Identity=24.6636771300448, Blast_Score=153, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17553506, Length=423, Percent_Identity=31.2056737588652, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=426, Percent_Identity=30.5164319248826, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=487, Percent_Identity=28.3367556468172, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320499, Length=437, Percent_Identity=20.8237986270023, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323943, Length=355, Percent_Identity=25.0704225352113, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24649634, Length=425, Percent_Identity=28.7058823529412, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19922976, Length=369, Percent_Identity=29.5392953929539, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24654597, Length=369, Percent_Identity=29.5392953929539, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24654592, Length=369, Percent_Identity=29.5392953929539, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 94233; Mature: 94102

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNTPMSENTTATTTVDPFADRESKNYENPVPSREFIISFLTDANIPMNRNDLFEALGL
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCC
AGEEQYEGLRRRLRAMERDGQLIFTRRQCYALPEKMELIKGFVIGHKDGHGWVRPDGSVG
CCHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHHEEECCCCCCCCCCCCCCC
KDNDIVLPHHQMKTIMHGDYVLVQPTDNSKRGRREGRLVRVLEERKTPLVGRFFLEYGHS
CCCCEECCHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHCCCCHHHHHHHHHCCE
YVVADDSRISHDIQIPTEHKGGARMGNVVVIEITDRGGRSRNMMGKVTEVLGENMAPGME
EEEECCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC
TQIAIRTHQIPQEWPEAVDKQIENLGEHVPEEAKEGRVDLRKLPLVTIDGEDARDFDDAV
EEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCCEE
YCEAKKGGGWRLWVAIADVSYYVRPETALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCS
EEEECCCCCEEEEEEEECCEEEECCCHHHCHHHHCCCCCEECCHHHHHHHHHHHCCCCCC
LNPQVDRLCMVCEMTISDKGKLSGYKHYEAVMNSHARLTYNKVGAILDGNEELRERYEPE
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEHHHHCEEECCCHHHHHHCCCC
VPHLEELHKMYKVLKKTRDERGAIEFETVETKFIFNADRKIDRIEPVIRNDAHKIIEECM
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
ILANIASASYVEKAKEPALYRVHDTPGEERLMGFKSFLSELGLTLEGGLSPSPVDYAQLM
HHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHH
QQINEREDRELIQTMLLRSMKQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIAKEEGRNSERWTPTGGYHYTFDDMDFYGEQCSMTERRADDATREVNDWLKCEYMQDH
HHHHHCCCCCCCCCCCCCCEEEEECCHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VGEVMDGVIANVTGFGFFVRLTELHIDGLVHISALANDYYQFDAVGQRLVGESSGNIYRL
HHHHHHHHHHHHHHHHHHEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GDSVKVKVSAVNLETRQIDFDLEDTDRQPRGKGKTAKKRAAEAMKKAKSKKRSAVKSNKP
CCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVPATPLVEPTKRPDGSSESSSKKKKSANKTGAAKARAKKKRAASRKPKADKS
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SKNTPMSENTTATTTVDPFADRESKNYENPVPSREFIISFLTDANIPMNRNDLFEALGL
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCC
AGEEQYEGLRRRLRAMERDGQLIFTRRQCYALPEKMELIKGFVIGHKDGHGWVRPDGSVG
CCHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHHEEECCCCCCCCCCCCCCC
KDNDIVLPHHQMKTIMHGDYVLVQPTDNSKRGRREGRLVRVLEERKTPLVGRFFLEYGHS
CCCCEECCHHHHHHHHCCCEEEEECCCCCCCCHHCCHHHHHHHHCCCCHHHHHHHHHCCE
YVVADDSRISHDIQIPTEHKGGARMGNVVVIEITDRGGRSRNMMGKVTEVLGENMAPGME
EEEECCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC
TQIAIRTHQIPQEWPEAVDKQIENLGEHVPEEAKEGRVDLRKLPLVTIDGEDARDFDDAV
EEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCCEE
YCEAKKGGGWRLWVAIADVSYYVRPETALDKEAINRGNSVYFPSQVVPMLPEVLSNGLCS
EEEECCCCCEEEEEEEECCEEEECCCHHHCHHHHCCCCCEECCHHHHHHHHHHHCCCCCC
LNPQVDRLCMVCEMTISDKGKLSGYKHYEAVMNSHARLTYNKVGAILDGNEELRERYEPE
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEHHHHCEEECCCHHHHHHCCCC
VPHLEELHKMYKVLKKTRDERGAIEFETVETKFIFNADRKIDRIEPVIRNDAHKIIEECM
CCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
ILANIASASYVEKAKEPALYRVHDTPGEERLMGFKSFLSELGLTLEGGLSPSPVDYAQLM
HHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHH
QQINEREDRELIQTMLLRSMKQAVYNADNAGHFGLALKRYAHFTSPIRRYPDLLLHRAIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIAKEEGRNSERWTPTGGYHYTFDDMDFYGEQCSMTERRADDATREVNDWLKCEYMQDH
HHHHHCCCCCCCCCCCCCCEEEEECCHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VGEVMDGVIANVTGFGFFVRLTELHIDGLVHISALANDYYQFDAVGQRLVGESSGNIYRL
HHHHHHHHHHHHHHHHHHEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GDSVKVKVSAVNLETRQIDFDLEDTDRQPRGKGKTAKKRAAEAMKKAKSKKRSAVKSNKP
CCCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GVPATPLVEPTKRPDGSSESSSKKKKSANKTGAAKARAKKKRAASRKPKADKS
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]