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The map label for this gene is mtaD [H]

Identifier: 218708330

GI number: 218708330

Start: 269907

End: 271373

Strand: Reverse

Name: mtaD [H]

Synonym: VS_0277

Alternate gene names: 218708330

Gene position: 271373-269907 (Counterclockwise)

Preceding gene: 218708336

Following gene: 218708327

Centisome position: 8.23

GC content: 43.97

Gene sequence:

>1467_bases
ATGAATGAAATACACTATTATCCACACACTTTACCAACACCTGTTCTGAGTACTGATATGAAACTAAAACGCACCCTATT
GGCTTCAGCGATGGCAAGCCTAGCTCTATTTCCATTTGCGAGTTCTGCAATGGAAAAAGCTGACCTGATGATAACCGATG
CCATGGTTCTAACCATGAACCAAGAAAAAACGGTTTACGAGAGCGGCACTGTTGTCGTTAAAGACAACAAAATCATTGCG
GTTGGCGATGCTTCGCTAGAGAAGCAGTACCAAGCTAAACAAGTGCTAGACGTTGATGGCGATATCGTAATGCCAGGTCT
CATCAATACTCATACTCACGTATCCATGACGGTTTTCCGTTCGTTGGCCGATGATGTGCCTGATCGCTTGCACCGCTACA
TCTTCCCACTTGAAGCTAAGTTAGTCTCTCGCGATATGGTTCGTATAGGCGCTAACCTTGGTAACGTTGAAATGGTAAAA
GGTGGCGTAACTACTTACGCTGATATGTACTACTTTGAAGACGAAGTCGCTAAAACTGTTGATAAAATTGGTATGCGCGC
AGTATTAGGCGAAACAGTAATCAAATTCCCAGTGGCTGATGCAGCAAACGCGGAAGAAGGTATTAAATACGCATTGAACT
TCATTGAAGAATATAAAGATCACCCGCGTATTACGCCTGCATTTGCTCCTCACGCCCCTTACACAAACACAACCGAAGTC
CTTCAAAAAGTAGCAAAGCTTTCTCTAGAACTTGATGTTCCAGTAATGATTCACTTAGCTGAATCTCATCGTGAAGAAGA
AAAAATTGCAAAACGAGCTGAAGGTTTATCTCCGGTTCAATACATGGACAGCATTGGTGCACTAAACAAAAACTTAGTTG
GCGCACACATGATCCTAGTAGACGATCATGATATCGAGCTAGTGAAAAAATCAGATATGGGCGTAGCTCACAACATGAGT
GCCAACATCAAGTCAGCAAAAGGCGTGTCACCTGCGCTTAAGATGTATGACGAAAATGTACGTATCGGTTTAGGTACTGA
TGGCCCAATGTCTGGTAACACATTGAGCACCATTGATGAGTTCAACCAAGTCGCTAAGGTTCACAAATTGGTGAATAAAG
ATCGTGCTGCAATGCCGCCGATCAAAGTGATCGACATGGCAACAATGGGCGCAGCAAAAGCACTACACATGGAAGATAAG
ATCGGCTCTCTTGAAGCAGGCAAGCTAGCCGACATCATAGTGATCGACACCAAGGCTCCAAACATGGTTCCTGTGTACAA
CCCATACTCTGCATTAGTTTACTCAGCTAACTCGGGGAACGTTCGTCACACCATCGTTGATGGCAAGATCATCATGCAAG
ATCGCGACATGCTAACGGTCGATGAAGATCAAATTCGCCAAGAAGCACTCGATTTCACCAAAGTCGTTCGTAAGACGGTA
ATTGAATCTGGTGAAGTTGTTCAGTAA

Upstream 100 bases:

>100_bases
AACCTAAGATTGATACATATCTTCACTTTGTGAAACATCACTTCGTAGACGCGGGCAATCATCAAAATTTCAAGCAAACG
ATAAAACAAACGTTTGCGCC

Downstream 100 bases:

>100_bases
CGTCATCGAATGAAATAAACGGCTTTCCGTTCAGATCAAAAAAGGCCTCATAGGTATTTACCTATGAGGCCTTTTTATAT
CGATATCTTTCTCGATCAAG

Product: chlorohydrolase/deaminase family protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNEIHYYPHTLPTPVLSTDMKLKRTLLASAMASLALFPFASSAMEKADLMITDAMVLTMNQEKTVYESGTVVVKDNKIIA
VGDASLEKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLADDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMVK
GGVTTYADMYYFEDEVAKTVDKIGMRAVLGETVIKFPVADAANAEEGIKYALNFIEEYKDHPRITPAFAPHAPYTNTTEV
LQKVAKLSLELDVPVMIHLAESHREEEKIAKRAEGLSPVQYMDSIGALNKNLVGAHMILVDDHDIELVKKSDMGVAHNMS
ANIKSAKGVSPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDK
IGSLEAGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHTIVDGKIIMQDRDMLTVDEDQIRQEALDFTKVVRKTV
IESGEVVQ

Sequences:

>Translated_488_residues
MNEIHYYPHTLPTPVLSTDMKLKRTLLASAMASLALFPFASSAMEKADLMITDAMVLTMNQEKTVYESGTVVVKDNKIIA
VGDASLEKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLADDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMVK
GGVTTYADMYYFEDEVAKTVDKIGMRAVLGETVIKFPVADAANAEEGIKYALNFIEEYKDHPRITPAFAPHAPYTNTTEV
LQKVAKLSLELDVPVMIHLAESHREEEKIAKRAEGLSPVQYMDSIGALNKNLVGAHMILVDDHDIELVKKSDMGVAHNMS
ANIKSAKGVSPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDK
IGSLEAGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHTIVDGKIIMQDRDMLTVDEDQIRQEALDFTKVVRKTV
IESGEVVQ
>Mature_488_residues
MNEIHYYPHTLPTPVLSTDMKLKRTLLASAMASLALFPFASSAMEKADLMITDAMVLTMNQEKTVYESGTVVVKDNKIIA
VGDASLEKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLADDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMVK
GGVTTYADMYYFEDEVAKTVDKIGMRAVLGETVIKFPVADAANAEEGIKYALNFIEEYKDHPRITPAFAPHAPYTNTTEV
LQKVAKLSLELDVPVMIHLAESHREEEKIAKRAEGLSPVQYMDSIGALNKNLVGAHMILVDDHDIELVKKSDMGVAHNMS
ANIKSAKGVSPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDK
IGSLEAGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHTIVDGKIIMQDRDMLTVDEDQIRQEALDFTKVVRKTV
IESGEVVQ

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=345, Percent_Identity=26.0869565217391, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1789249, Length=414, Percent_Identity=23.6714975845411, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17540282, Length=371, Percent_Identity=22.911051212938, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=26.2686567164179, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643849, Length=432, Percent_Identity=25.6944444444444, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 53685; Mature: 53685

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIHYYPHTLPTPVLSTDMKLKRTLLASAMASLALFPFASSAMEKADLMITDAMVLTMN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEC
QEKTVYESGTVVVKDNKIIAVGDASLEKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFR
CCCEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHH
SLADDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
DKIGMRAVLGETVIKFPVADAANAEEGIKYALNFIEEYKDHPRITPAFAPHAPYTNTTEV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LQKVAKLSLELDVPVMIHLAESHREEEKIAKRAEGLSPVQYMDSIGALNKNLVGAHMILV
HHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
DDHDIELVKKSDMGVAHNMSANIKSAKGVSPALKMYDENVRIGLGTDGPMSGNTLSTIDE
ECCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
FNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDKIGSLEAGKLADIIVIDTKAP
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHCHHHHEEHHHCCCCCCCCCEEEEEEEECCCC
NMVPVYNPYSALVYSANSGNVRHTIVDGKIIMQDRDMLTVDEDQIRQEALDFTKVVRKTV
CEEEEECCCEEEEEECCCCCEEEEEECCEEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
IESGEVVQ
HCCCCCCC
>Mature Secondary Structure
MNEIHYYPHTLPTPVLSTDMKLKRTLLASAMASLALFPFASSAMEKADLMITDAMVLTMN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEC
QEKTVYESGTVVVKDNKIIAVGDASLEKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFR
CCCEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHH
SLADDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMVKGGVTTYADMYYFEDEVAKTV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
DKIGMRAVLGETVIKFPVADAANAEEGIKYALNFIEEYKDHPRITPAFAPHAPYTNTTEV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LQKVAKLSLELDVPVMIHLAESHREEEKIAKRAEGLSPVQYMDSIGALNKNLVGAHMILV
HHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEE
DDHDIELVKKSDMGVAHNMSANIKSAKGVSPALKMYDENVRIGLGTDGPMSGNTLSTIDE
ECCCEEEEEECCCCEEECCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
FNQVAKVHKLVNKDRAAMPPIKVIDMATMGAAKALHMEDKIGSLEAGKLADIIVIDTKAP
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHCHHHHEEHHHCCCCCCCCCEEEEEEEECCCC
NMVPVYNPYSALVYSANSGNVRHTIVDGKIIMQDRDMLTVDEDQIRQEALDFTKVVRKTV
CEEEEECCCEEEEEECCCCCEEEEEECCEEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
IESGEVVQ
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA