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The map label for this gene is groEL [H]

Identifier: 218708301

GI number: 218708301

Start: 234837

End: 236483

Strand: Direct

Name: groEL [H]

Synonym: VS_0239

Alternate gene names: 218708301

Gene position: 234837-236483 (Clockwise)

Preceding gene: 218708300

Following gene: 218708302

Centisome position: 7.12

GC content: 47.91

Gene sequence:

>1647_bases
ATGGCTGCTAAAGACGTTAAATTTGGTAACGACGCACGTATTAAAATGCTAGAAGGTGTAAACGTTCTGGCTGACGCAGT
AAAAGTAACGCTAGGTCCTAAAGGCCGTAACGTTGTTCTAGACAAATCATTTGGCGCACCAACGATCACTAAAGATGGTG
TTTCAGTTGCACGTGAAATCGAACTTGAAGACAAGTTTCAAAACATGGGCGCACAAATGGTTAAAGAAGTGGCTTCGCAA
GCGAATGACGCGGCGGGCGACGGAACAACGACAGCAACAGTATTGGCTCAGTCTATTATCGCTGAAGGCCTAAAAGCCGT
TGCTGCTGGCATGAACCCAATGGACCTTAAGCGCGGTATCGACAAAGCGGTTATCGCGGCTGTTGAAGAGCTGAAGAACC
TTTCTGTTCCTTGTTCAGACACGAAAGCTATCGCGCAAGTAGGTACTATCTCTGCGAACTCTGATTCGACAGTAGGTAAC
ATCATTGCTGAAGCGATGGAAAAAGTAGGTCGTGATGGCGTCATCACGGTTGAAGAAGGTCAGGCTCTGCAAGACGAGCT
AGACGTAGTTGAAGGTATGCAGTTCGACCGCGGTTACCTGTCTCCTTACTTCATCAACAACCAAGAAGCAGGTTCTGTTG
ATCTAGATAGCCCGTTCATTCTTCTTATCGACAAGAAAGTGTCTAACATCCGTGAACTTCTTCCGACTCTAGAAGCGGTT
GCTAAGGCATCTCGTCCACTTCTTATCATCGCTGAAGATGTCGAAGGCGAAGCGCTAGCAACTCTTGTTGTGAACAACAT
GCGTGGCATCGTTAAAGTGGCTGCGGTTAAAGCACCTGGTTTCGGCGACCGTCGTAAATCTATGCTGCAAGACATCGCTA
TCCTAACAGGCGGCACGGTTATCTCTGAAGAGATCGGCCTAGACCTTGAAAAAGTAACGCTAGAAGACCTAGGTCAAGCT
AAGCGCATTACGATCACTAAAGAAAACTCAACCATCATCGATGGTGCGGGTAATGAAGATATGATCAAAGGTCGCGTTTC
TCAAATTCGTCAACAAATCGAAGATGCAACGTCTGACTACGATAAAGAAAAACTTCAAGAGCGCGTAGCTAAGCTAGCTG
GCGGTGTTGCAGTAATCAAAGTAGGCGCTGCAACTGAAGTTGAGATGAAAGAGAAGAAAGACCGCGTAGAAGATGCACTT
CACGCAACTCGCGCTGCTGTTGAAGAAGGTGTGGTTGCTGGTGGTGGTGTTGCACTTATCCGCGCTGCATCTAAAGTTGC
TGGCCTTGAAGGCGACAACGAAGAGCAAAACGTAGGTATCCGTGTTGCACTACGTGCAATGGAAGCGCCTATTCGTCAAA
TCACTAAGAACGCAGGTGATGAAGAGTCTGTTGTTGCTAACAATGTTCGTGCTGGCGAAGGTAACTACGGTTACAACGCG
GCTACTGGCGAATACGGCGACATGATTGCAATGGGTATCCTAGATCCAACTAAGGTAACTCGTTCTGCACTTCAGTTCGC
CGCATCCGTTGCGGGTCTTATGATCACAACAGAAGCGATGATCACAGACAAACCTCAAGATTCTGGCCCTGCAATGCCTG
ATATGGGTGGCATGGGCGGTATGGGTGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
GAAGTACTGATAATGTCTGAGTTCAATATCATGGCGATCGTTGAGTAATCCGACCCATAAAACTGAACTGACTGAATAAA
GAATTTTAAAGGAAATTAAG

Downstream 100 bases:

>100_bases
TCATCCCCCTTTCTCGTAACAGAGAAAGTCATACATAAGCTTTAGAAAACGGAGACTTCGGTCTCCGTTTTTTTATGCTT
TGAAATCGTCACTCCGACAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQ
ANDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEELKNLSVPCSDTKAIAQVGTISANSDSTVGN
IIAEAMEKVGRDGVITVEEGQALQDELDVVEGMQFDRGYLSPYFINNQEAGSVDLDSPFILLIDKKVSNIRELLPTLEAV
AKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAILTGGTVISEEIGLDLEKVTLEDLGQA
KRITITKENSTIIDGAGNEDMIKGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDAL
HATRAAVEEGVVAGGGVALIRAASKVAGLEGDNEEQNVGIRVALRAMEAPIRQITKNAGDEESVVANNVRAGEGNYGYNA
ATGEYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSGPAMPDMGGMGGMGGMGGMM

Sequences:

>Translated_548_residues
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQ
ANDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEELKNLSVPCSDTKAIAQVGTISANSDSTVGN
IIAEAMEKVGRDGVITVEEGQALQDELDVVEGMQFDRGYLSPYFINNQEAGSVDLDSPFILLIDKKVSNIRELLPTLEAV
AKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAILTGGTVISEEIGLDLEKVTLEDLGQA
KRITITKENSTIIDGAGNEDMIKGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDAL
HATRAAVEEGVVAGGGVALIRAASKVAGLEGDNEEQNVGIRVALRAMEAPIRQITKNAGDEESVVANNVRAGEGNYGYNA
ATGEYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSGPAMPDMGGMGGMGGMGGMM
>Mature_547_residues
AAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQA
NDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEELKNLSVPCSDTKAIAQVGTISANSDSTVGNI
IAEAMEKVGRDGVITVEEGQALQDELDVVEGMQFDRGYLSPYFINNQEAGSVDLDSPFILLIDKKVSNIRELLPTLEAVA
KASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAILTGGTVISEEIGLDLEKVTLEDLGQAK
RITITKENSTIIDGAGNEDMIKGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALH
ATRAAVEEGVVAGGGVALIRAASKVAGLEGDNEEQNVGIRVALRAMEAPIRQITKNAGDEESVVANNVRAGEGNYGYNAA
TGEYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSGPAMPDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=50.9505703422053, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=50.9505703422053, Blast_Score=540, Evalue=1e-153,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=85.3889943074004, Blast_Score=897, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=51.1363636363636, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=49.5238095238095, Blast_Score=203, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.2319391634981, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=26.5432098765432, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=53.6121673003802, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=53.6121673003802, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=50.5725190839695, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=50.5725190839695, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=50.5725190839695, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=41.3284132841328, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=37.5700934579439, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=37.5700934579439, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57517; Mature: 57386

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00284 SERPIN ; PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFQNMGAQMVKEVASQANDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVEELKNLSVPCSDTKAIAQVGTISANSDSTVGNIIAEAMEKVGRDGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
QALQDELDVVEGMQFDRGYLSPYFINNQEAGSVDLDSPFILLIDKKVSNIRELLPTLEAV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCEEEEECCHHHHHHHHHHHHHHH
AKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEIGLDLEKVTLEDLGQAKRITITKENSTIIDGAGNEDMIKGRVSQIRQQIEDATSDY
EHHHHCCCHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAGLEGDNEEQNVGIRVALRAMEAPIRQITKNAGDEESVVANNVRAGEGNYGYNA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCC
ATGEYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSGPAMPDMGGMGG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC
>Mature Secondary Structure 
AAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFQNMGAQMVKEVASQANDAAGDGTTTATVLAQSIIAEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVEELKNLSVPCSDTKAIAQVGTISANSDSTVGNIIAEAMEKVGRDGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
QALQDELDVVEGMQFDRGYLSPYFINNQEAGSVDLDSPFILLIDKKVSNIRELLPTLEAV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCEEEEECCHHHHHHHHHHHHHHH
AKASRPLLIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKSMLQDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEIGLDLEKVTLEDLGQAKRITITKENSTIIDGAGNEDMIKGRVSQIRQQIEDATSDY
EHHHHCCCHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAGLEGDNEEQNVGIRVALRAMEAPIRQITKNAGDEESVVANNVRAGEGNYGYNA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCC
ATGEYGDMIAMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSGPAMPDMGGMGG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA