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The map label for this gene is prlC [H]

Identifier: 218708150

GI number: 218708150

Start: 75822

End: 77864

Strand: Direct

Name: prlC [H]

Synonym: VS_0084

Alternate gene names: 218708150

Gene position: 75822-77864 (Clockwise)

Preceding gene: 218708145

Following gene: 218708152

Centisome position: 2.3

GC content: 48.8

Gene sequence:

>2043_bases
ATGTCTAATCCGCTATTAACCTTCACGGACTTACCTCCGTTTTCACAGATCAAACCTGAGCACGTTAAGCCAGCGGTTGA
GCAAGTGATTGAAGAGTGTCGCAACAAGATAGAACAAGTACTTGAAGGTAATACTTCACCAAGCTGGGACAACCTCGTTG
CTCCAATTGATGAAGTGGATGATCGTTTAGGCCGCCTTTGGTCACCTGTAAGCCATATGAATTCTGTGATGAACAGCGAC
GAACTGCGTGACGCTTATGAGAGCTGCCTGCCTGTACTTTCTGAGTACGGCACGTGGGTCGGCCAACACAAAGGTTTGTT
CGAAGCGTATAAAGCGATCAAGGCGAGCGAAGCATTCTCGGCATTAAACCAAGCTCAACAAAAAACCATCACTGACGCAC
TGCGTGATTTTGAATTATCAGGCATTGGCTTACCAGCGGACGAACAGCATCGCTACGGTGAGATCAGCAAGCGCCAGTCT
GAGCTAGGTTCTCAATTCTCAAATAACGTGCTTGATGCAACCATGGGTTGGAGCAAGCAGATCACAGACGTGGCTGAACT
GGCCGGTATGCCTGAATCAGCACTGGCGGCAGCACAAGCCGCGGCAGAAGCTAAAGAGCAAGAAGGTTACCTACTGACTC
TGGATATCCCATCATACCTACCTGTGATGACCTACTGTGATAACCAAGATCTACGCAAAGAGCTTTACGAAGCTTACGTA
ACGCGTGCTTCAGATCGCGGTCCAAATGCTGGCAAGTGGGACAACACTGAGATCATCACTGAGCAACTTAAGCTGCGTCA
TGAGATCGCACGCATGCTTGGCTTTAGCACTTACAGCGAAAAATCTCTGTCGACTAAGATGGCAGAAACGCCAGACCAAG
TACTTGGTTTCCTTAACGACCTAGCAGTAAAAGCTAAACCACAAGGTGAGCGCGAAGTAGAAGAGCTACGTCAGTTTGCT
GAGAAAGAGTTTGGTGTCTCTGAGCTAAACCTGTGGGACATCGCTTACTACAGCGAGAAACAAAAACAGAACTTGTTCGA
GATCTCTGATGAAGAGCTTCGTCCATACTTCCCTGAGTCGAACGCAGTGTCTGGTTTGTTCGAAGTACTAAACCGTGTGT
TTGGTATGTCTGTGACTGAGCGTGAAGGTGTGGATACATGGCATGATTCAGTGCGCTTCTTCGACATCTTTGATGCGACA
GGCACATTGCGCGGTAGCTTCTATCTAGACCTATACGCACGTGAACACAAACGTGGTGGCGCTTGGATGGATGACTGTCG
CGGTCGTCGCATTACTCAATCTGGCGAGTTACAAACGCCAGTGGCTTACCTTACGTGTAACTTCAACAAGCCAGTCGGTG
ATAAGCCTGCGCTATTTACGCACGATGAAGTGGTAACCTTGTTCCACGAATTCGGCCACGGTATTCACCATATGTTAACG
CAAGTTGATGCGAGTGCGGTTTCTGGTATCAATGGCGTGCCTTGGGACGCGGTTGAGTTGCCAAGTCAGTTCCTCGAGAA
CTGGTGTTGGGAAGAGGAGGCGTTGTCGTTCATCTCTGGTCATTTCGAAACTGGTGAAGCGTTACCGAAAGAGATGCTAG
AGAAGATGCTAGCGGCGAAAAACTTCCAATCTGCGATGTTTATCCTACGTCAGCTAGAGCTTGGCTTATTCGATTTCACA
CTGCACACAGAATACGATCCAGAAGTCGGTGCTCGCGTACTCGAAACGTTAGCTGACGTGAAGTCTAAGGTATCGGTATT
GCCAAGTCTTGATTGGAACCGCTTCTCGCACAGCTTTGGGCATATCTTTGCTGGTGGCTACAGCGCAGGTTACTACAGCT
ACCTGTGGGCAGAAGTATTGTCTGCAGATGCGTTCTCAGCATTTGAAGAAGAAGGTATCTTCAATACCGAAACCGGTAAT
CGCTTCCTGAACAACATCCTTGAAATGGGTGGCAGTGAAGAGCCAATGGAGCTGTTCAAACGCTTCCGTGGTCGTGAGCC
TCAAATCGACGCGATGCTACGTCATGCGGGTATCAGCGCTTAA

Upstream 100 bases:

>100_bases
TATTCGCAGGTGATTTTTTAGGGCGATCCTTAGCCTGATGACTGTAAGACGACCTCATTACAAAAAAGACGAAAGTCTCT
AAAGCCAAAGGAATGTTTAT

Downstream 100 bases:

>100_bases
TATTGTGCTAGTCAGAATGTGAAAAGAGCCTCCTTGTGAGGCTCTTTTTGTATCGATTTATCAAACGATTATGGATTCAC
ATTGCGGTTGATAGGGTTCT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MSNPLLTFTDLPPFSQIKPEHVKPAVEQVIEECRNKIEQVLEGNTSPSWDNLVAPIDEVDDRLGRLWSPVSHMNSVMNSD
ELRDAYESCLPVLSEYGTWVGQHKGLFEAYKAIKASEAFSALNQAQQKTITDALRDFELSGIGLPADEQHRYGEISKRQS
ELGSQFSNNVLDATMGWSKQITDVAELAGMPESALAAAQAAAEAKEQEGYLLTLDIPSYLPVMTYCDNQDLRKELYEAYV
TRASDRGPNAGKWDNTEIITEQLKLRHEIARMLGFSTYSEKSLSTKMAETPDQVLGFLNDLAVKAKPQGEREVEELRQFA
EKEFGVSELNLWDIAYYSEKQKQNLFEISDEELRPYFPESNAVSGLFEVLNRVFGMSVTEREGVDTWHDSVRFFDIFDAT
GTLRGSFYLDLYAREHKRGGAWMDDCRGRRITQSGELQTPVAYLTCNFNKPVGDKPALFTHDEVVTLFHEFGHGIHHMLT
QVDASAVSGINGVPWDAVELPSQFLENWCWEEEALSFISGHFETGEALPKEMLEKMLAAKNFQSAMFILRQLELGLFDFT
LHTEYDPEVGARVLETLADVKSKVSVLPSLDWNRFSHSFGHIFAGGYSAGYYSYLWAEVLSADAFSAFEEEGIFNTETGN
RFLNNILEMGGSEEPMELFKRFRGREPQIDAMLRHAGISA

Sequences:

>Translated_680_residues
MSNPLLTFTDLPPFSQIKPEHVKPAVEQVIEECRNKIEQVLEGNTSPSWDNLVAPIDEVDDRLGRLWSPVSHMNSVMNSD
ELRDAYESCLPVLSEYGTWVGQHKGLFEAYKAIKASEAFSALNQAQQKTITDALRDFELSGIGLPADEQHRYGEISKRQS
ELGSQFSNNVLDATMGWSKQITDVAELAGMPESALAAAQAAAEAKEQEGYLLTLDIPSYLPVMTYCDNQDLRKELYEAYV
TRASDRGPNAGKWDNTEIITEQLKLRHEIARMLGFSTYSEKSLSTKMAETPDQVLGFLNDLAVKAKPQGEREVEELRQFA
EKEFGVSELNLWDIAYYSEKQKQNLFEISDEELRPYFPESNAVSGLFEVLNRVFGMSVTEREGVDTWHDSVRFFDIFDAT
GTLRGSFYLDLYAREHKRGGAWMDDCRGRRITQSGELQTPVAYLTCNFNKPVGDKPALFTHDEVVTLFHEFGHGIHHMLT
QVDASAVSGINGVPWDAVELPSQFLENWCWEEEALSFISGHFETGEALPKEMLEKMLAAKNFQSAMFILRQLELGLFDFT
LHTEYDPEVGARVLETLADVKSKVSVLPSLDWNRFSHSFGHIFAGGYSAGYYSYLWAEVLSADAFSAFEEEGIFNTETGN
RFLNNILEMGGSEEPMELFKRFRGREPQIDAMLRHAGISA
>Mature_679_residues
SNPLLTFTDLPPFSQIKPEHVKPAVEQVIEECRNKIEQVLEGNTSPSWDNLVAPIDEVDDRLGRLWSPVSHMNSVMNSDE
LRDAYESCLPVLSEYGTWVGQHKGLFEAYKAIKASEAFSALNQAQQKTITDALRDFELSGIGLPADEQHRYGEISKRQSE
LGSQFSNNVLDATMGWSKQITDVAELAGMPESALAAAQAAAEAKEQEGYLLTLDIPSYLPVMTYCDNQDLRKELYEAYVT
RASDRGPNAGKWDNTEIITEQLKLRHEIARMLGFSTYSEKSLSTKMAETPDQVLGFLNDLAVKAKPQGEREVEELRQFAE
KEFGVSELNLWDIAYYSEKQKQNLFEISDEELRPYFPESNAVSGLFEVLNRVFGMSVTEREGVDTWHDSVRFFDIFDATG
TLRGSFYLDLYAREHKRGGAWMDDCRGRRITQSGELQTPVAYLTCNFNKPVGDKPALFTHDEVVTLFHEFGHGIHHMLTQ
VDASAVSGINGVPWDAVELPSQFLENWCWEEEALSFISGHFETGEALPKEMLEKMLAAKNFQSAMFILRQLELGLFDFTL
HTEYDPEVGARVLETLADVKSKVSVLPSLDWNRFSHSFGHIFAGGYSAGYYSYLWAEVLSADAFSAFEEEGIFNTETGNR
FLNNILEMGGSEEPMELFKRFRGREPQIDAMLRHAGISA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=611, Percent_Identity=32.569558101473, Blast_Score=327, Evalue=3e-89,
Organism=Homo sapiens, GI14149738, Length=675, Percent_Identity=30.6666666666667, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI156105687, Length=632, Percent_Identity=24.6835443037975, Blast_Score=177, Evalue=4e-44,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=68.9705882352941, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=31.1499272197962, Blast_Score=308, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI71999758, Length=573, Percent_Identity=25.4799301919721, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565901, Length=687, Percent_Identity=20.3784570596798, Blast_Score=99, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319793, Length=689, Percent_Identity=29.8984034833091, Blast_Score=304, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=692, Percent_Identity=24.5664739884393, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI21356111, Length=582, Percent_Identity=28.6941580756014, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI20129717, Length=641, Percent_Identity=23.7129485179407, Blast_Score=178, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76711; Mature: 76579

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLTFTDLPPFSQIKPEHVKPAVEQVIEECRNKIEQVLEGNTSPSWDNLVAPIDEVD
CCCCCEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHH
DRLGRLWSPVSHMNSVMNSDELRDAYESCLPVLSEYGTWVGQHKGLFEAYKAIKASEAFS
HHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALNQAQQKTITDALRDFELSGIGLPADEQHRYGEISKRQSELGSQFSNNVLDATMGWSKQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
ITDVAELAGMPESALAAAQAAAEAKEQEGYLLTLDIPSYLPVMTYCDNQDLRKELYEAYV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHHH
TRASDRGPNAGKWDNTEIITEQLKLRHEIARMLGFSTYSEKSLSTKMAETPDQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAVKAKPQGEREVEELRQFAEKEFGVSELNLWDIAYYSEKQKQNLFEISDEELRPYFPES
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
NAVSGLFEVLNRVFGMSVTEREGVDTWHDSVRFFDIFDATGTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCEEEEEECCCCCCCCEEEEEEHHHHHCCCC
AWMDDCRGRRITQSGELQTPVAYLTCNFNKPVGDKPALFTHDEVVTLFHEFGHGIHHMLT
CCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
QVDASAVSGINGVPWDAVELPSQFLENWCWEEEALSFISGHFETGEALPKEMLEKMLAAK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NFQSAMFILRQLELGLFDFTLHTEYDPEVGARVLETLADVKSKVSVLPSLDWNRFSHSFG
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
HIFAGGYSAGYYSYLWAEVLSADAFSAFEEEGIFNTETGNRFLNNILEMGGSEEPMELFK
HHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQIDAMLRHAGISA
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLTFTDLPPFSQIKPEHVKPAVEQVIEECRNKIEQVLEGNTSPSWDNLVAPIDEVD
CCCCEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHH
DRLGRLWSPVSHMNSVMNSDELRDAYESCLPVLSEYGTWVGQHKGLFEAYKAIKASEAFS
HHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALNQAQQKTITDALRDFELSGIGLPADEQHRYGEISKRQSELGSQFSNNVLDATMGWSKQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
ITDVAELAGMPESALAAAQAAAEAKEQEGYLLTLDIPSYLPVMTYCDNQDLRKELYEAYV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCHHHHHHHHHHHH
TRASDRGPNAGKWDNTEIITEQLKLRHEIARMLGFSTYSEKSLSTKMAETPDQVLGFLND
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAVKAKPQGEREVEELRQFAEKEFGVSELNLWDIAYYSEKQKQNLFEISDEELRPYFPES
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
NAVSGLFEVLNRVFGMSVTEREGVDTWHDSVRFFDIFDATGTLRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCEEEEEECCCCCCCCEEEEEEHHHHHCCCC
AWMDDCRGRRITQSGELQTPVAYLTCNFNKPVGDKPALFTHDEVVTLFHEFGHGIHHMLT
CCHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
QVDASAVSGINGVPWDAVELPSQFLENWCWEEEALSFISGHFETGEALPKEMLEKMLAAK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
NFQSAMFILRQLELGLFDFTLHTEYDPEVGARVLETLADVKSKVSVLPSLDWNRFSHSFG
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
HIFAGGYSAGYYSYLWAEVLSADAFSAFEEEGIFNTETGNRFLNNILEMGGSEEPMELFK
HHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQIDAMLRHAGISA
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]