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The map label for this gene is kdgR [H]

Identifier: 218705326

GI number: 218705326

Start: 2142738

End: 2143529

Strand: Reverse

Name: kdgR [H]

Synonym: ECUMN_2121

Alternate gene names: 218705326

Gene position: 2143529-2142738 (Counterclockwise)

Preceding gene: 218705328

Following gene: 218705325

Centisome position: 41.21

GC content: 49.62

Gene sequence:

>792_bases
ATGGCTAACGCAGATCTGGATAAACAGCCTGATTCTGTATCTTCCGTGCTAAAAGTTTTTGGCATTTTGCAGGCGCTGGG
TGAAGAGCGCGAAATAGGGATAACCGAGCTGTCGCAGCGCGTCATGATGTCAAAAAGCACCGTTTATCGCTTTTTACAGA
CCATGAAAACCCTGGGTTATGTGGCGCAGGAAGGGGAGTCGGAGAAATATTCCCTGACCCTGAAATTGTTTGAACTGGGC
GCTCGCGCGTTACAAAACGTCGATTTAATTCGTAGCGCAGATATCCAGATGCGTGAGATCTCCCGCCTGACCAAAGAAAC
TATCCACCTCGGCGCACTGGACGAAGACAGTATTGTTTACATTCACAAAATTGACTCTATGTACAATTTGCGCATGTATT
CACGGATTGGGCGTCGTAATCCGCTGTACAGCACCGCGATTGGTAAGGTACTGCTGGCATGGCGCGATCGCGATGAAGTG
AAGCAAATTCTTGAGGGCGTGGAGTATAAACGCAGTACCGAACGGACCATCATCAGTACAGAAGCGTTATTACCCGTTCT
GGACCAGGTGCGCGAGCAGGGGTATGGCGAAGATAACGAAGAGCAGGAAGAAGGACTGCGTTGCATTGCGGTTCCGGTAT
TTGATCGCTTTGGCGTGGTCATTGCCGGTCTTAGCATCTCCTTCCCGACGTTGCGTTTCTCTGAAGAGCGTTTACAGGAA
TATGTCGCAATGTTGCATACCGCGGCGCGCAAAATTTCTGCCCAAATGGGTTATCACGACTATCCATTCTGA

Upstream 100 bases:

>100_bases
TTGTAACTAACCGGCAAAAGATGGATTGCGACCACCCTGGTGCGAAATTATAATAAAAAACAGTTCTGATTTTTATAAAA
CACTCGCAATGAGGTGATAA

Downstream 100 bases:

>100_bases
TGAGAGTAAGAACCTGTCTGAATATCAAACAGACAGGTTCTTTATTTAGCATGAGAAAAATAAAGTTGAAGGTGGCGTTA
TATTAAACGCACTTGCGATA

Product: DNA-binding transcriptional repressor KdgR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELG
ARALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEV
KQILEGVEYKRSTERTIISTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQE
YVAMLHTAARKISAQMGYHDYPF

Sequences:

>Translated_263_residues
MANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELG
ARALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEV
KQILEGVEYKRSTERTIISTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQE
YVAMLHTAARKISAQMGYHDYPF
>Mature_262_residues
ANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGA
RALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVK
QILEGVEYKRSTERTIISTEALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQEY
VAMLHTAARKISAQMGYHDYPF

Specific function: Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism, including the pel genes encoding pectate lyases, kdgT which encodes the 2-keto-3-deoxygluconate transport system

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=263, Percent_Identity=99.2395437262358, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1786468, Length=247, Percent_Identity=41.7004048582996, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789999, Length=228, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082359, Length=248, Percent_Identity=29.4354838709677, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786715, Length=229, Percent_Identity=29.6943231441048, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790752, Length=226, Percent_Identity=30.9734513274336, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788581, Length=222, Percent_Identity=31.981981981982, Blast_Score=107, Evalue=8e-25,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30042; Mature: 29911

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQEGESEKYSLTLKLFELGARALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVY
HHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVKQILEGVEYKRSTERTIIST
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
EALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQE
HHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
YVAMLHTAARKISAQMGYHDYPF
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ANADLDKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGY
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQEGESEKYSLTLKLFELGARALQNVDLIRSADIQMREISRLTKETIHLGALDEDSIVY
HHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDRDEVKQILEGVEYKRSTERTIIST
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
EALLPVLDQVREQGYGEDNEEQEEGLRCIAVPVFDRFGVVIAGLSISFPTLRFSEERLQE
HHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
YVAMLHTAARKISAQMGYHDYPF
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1840643; 1545709 [H]