Click here to switch to the map view.

The map label for this gene is astC [H]

Identifier: 218705246

GI number: 218705246

Start: 2065180

End: 2066400

Strand: Reverse

Name: astC [H]

Synonym: ECUMN_2037

Alternate gene names: 218705246

Gene position: 2066400-2065180 (Counterclockwise)

Preceding gene: 218705256

Following gene: 218705245

Centisome position: 39.72

GC content: 55.12

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCTCCGGCACCGTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCACCCGGAACTGCGTGAGGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCGCTAAAACTGGCGCGTAAATTCGCTCACGACCGCTACGGCAGCCATAAGAGCGGTATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGTGGGCAGCCCGCCTATTCACAGGATTTTGCGCCA
CTGCCGCCGGATATTCGTCATGCTGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACTCTACCTGTGCGGT
GATTGTCGAACCCATCCAGGGGGAAGGCGGTGTGGTGCCAGCCAGCAACGCATTTTTACATGGTCTGCGTGAATTGTGTG
ACCGCCACAATGCATTGCTGATTTTTGATGAAGTACAAACTGGCGTCGGGCGCACCGGGGAACTGTATGCCTATATGCAC
TACGGTGTGACGCCTGATCTGTTAACTACCGCGAAAGCGCTGGGCGGCGGTTTCCCGGTCGGTGCGTTGTTGGCAACCGA
AGAGTGCGCCAGCGTGATGACCGTTGGCACTCATGGCACCACCTATGGTGGTAATCCGCTGGCCTCGGCGGTAGCAGGCA
AAGTGCTGGATCTCATTAACACGCCAGAGATGCTTAACGGGGTTAAGCAGCGTCACGACTGGTTTGTTGAGCGTCTTAAT
ACCGTTAATCACCGCTGCGGTTTGTTCAGTGAAGTTCGCGGCTTAGGTTTGTTGATTGGCTGTGTACTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGCGAAAGCAGGCGTGATGGTACTGATTGCGGGTGGCAACGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGACCACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTATTAACATATAAATAACGAAT
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGCTCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
TVNHRCGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACDHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
TVNHRCGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACDHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLNT
VNHRCGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACDHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.8284960422164, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.4948805460751, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=27.765237020316, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI37574042, Length=414, Percent_Identity=27.536231884058, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442705, Length=414, Percent_Identity=26.8115942028986, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI226442709, Length=379, Percent_Identity=27.7044854881267, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI24119277, Length=411, Percent_Identity=27.007299270073, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI188536080, Length=427, Percent_Identity=23.8875878220141, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38679950, Length=427, Percent_Identity=23.8875878220141, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38679946, Length=427, Percent_Identity=23.8875878220141, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=98.0295566502463, Blast_Score=823, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=59.9496221662469, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=33.2512315270936, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=35.0267379679144, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.8717948717949, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=32.1428571428571, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.7702702702703, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.2941176470588, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.6551724137931, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=33.7979094076655, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.8683602771363, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=34.5454545454545, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=26.2987012987013, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=39.5522388059701, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=400, Percent_Identity=34, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.9230769230769, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=430, Percent_Identity=23.953488372093, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.6200527704486, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.4247787610619, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.438202247191, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=29.0858725761773, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281366494, Length=425, Percent_Identity=24.7058823529412, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667139, Length=425, Percent_Identity=24.7058823529412, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667143, Length=425, Percent_Identity=24.7058823529412, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43531; Mature: 43399

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTVNHRCGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACDHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTVNHRCGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACDHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA