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The map label for this gene is chbC

Identifier: 218705235

GI number: 218705235

Start: 2054274

End: 2055632

Strand: Reverse

Name: chbC

Synonym: ECUMN_2026

Alternate gene names: 218705235

Gene position: 2055632-2054274 (Counterclockwise)

Preceding gene: 218705236

Following gene: 218705234

Centisome position: 39.52

GC content: 49.01

Gene sequence:

>1359_bases
ATGAGTAATGTTATTGCATCGCTTGAAAAGGTACTCCTCCCTTTTGCAGTTAAAATAGGAAAGCAGCCACACGTTAATGC
AATCAAAAATGGCTTTATTCGCTTAATGCCGTTAACCCTTGCGGGGGCCATGTTTGTATTAATTAACAACGTTTTTCTAA
GCTTTGGGGAGGGGTCGTTTTTTTATTCCTTAGGTATTCGCCTGGATGCCTCAACCATTGAAACACTTAATGGTCTGAAA
GGTATTGGCGGCAACGTATATAACGGAACATTAGGGATAATGTCTTTAATGGCACCGTTCTTTATTGGCATGGCGCTGGC
AGAAGAGCGTAAAGTCGATGCGCTGGCGGCTGGGTTGTTATCCGTTGCAGCATTTATGACCGTCACCCCATACAGTGTCG
GTGAGGCCTATGCGGTTGGCGCAAACTGGTTAGGTGGGGCGAATATCATCTCCGGGATTATTATTGGCCTGGTGGTGGCA
GAAATGTTTACCTTTATTGTCCGCCGCAATTGGGTCATTAAATTGCCCGATAGCGTACCTGCTTCAGTATCGCGTTCCTT
CTCGGCTTTAATTCCCGGCTTTATTATTCTTTCCGTGATGGGGATTATTGCCTGGGCGTTGAATACCTGGGGCACCAACT
TCCATCAGATCATTATGGATACCATCTCAACCCCACTGGCATCGTTGGGTAGCGTGGTGGGCTGGGCCTATGTGATCTTT
GTTCCACTGCTCTGGTTCTTCGGTATTCATGGTGCGCTGGCGCTGACCGCACTGGACAACGGCATTATGACGCCTTGGGC
GCTGGAAAATATCGCGACCTATCAGCAATATGGTTCCGTCGAAGCGGCGCTGGCAGCCGGTAAGACCTTCCATATCTGGG
CCAAGCCGATGCTGGACTCCTTTATTTTCCTTGGGGGCAGTGGTGCGACTTTAGGTCTGATCCTGGCTATCTTTATCGCC
TCTCGCCGTGCTGATTATCGTCAGGTGGCAAAACTGGCGCTGCCGTCCGGCATCTTCCAGATTAACGAACCGATTCTGTT
TGGTCTGCCAATTATCATGAACCCGGTGATGTTTATCCCGTTTGTACTGGTACAACCGATTCTGGCGGCAATCACCCTGG
CAGCGTACTACATGGGCATTATTCCTCCGGTGACCAATATTGCACCGTGGACCATGCCAACCGGTCTGGGAGCCTTCTTT
AACACCAACGGTAGCGTCGCCGCATTGCTGGTCGCACTCTTCAACCTTGGTATCGCAACGTTAATTTATCTGCCCTTTGT
TGTGGTGGCTAACAAAGCACAAAATGCGATTGATAAAGAAGAGAGCGAAGAAGATATCGCTAACGCCCTGAAATTTTAA

Upstream 100 bases:

>100_bases
AGCCGCAGCAAATTAATTTATTTTAAATTTTCCCGTCAAAGAGTTATTTCATAAATCAATACCGCAATATTTAAATTGCG
GTTTTTAAGGGTATTTTTCT

Downstream 100 bases:

>100_bases
TCGATGCCGGTACGGGTAATCGTGCCGGTAAGAATAGAGAGGAACGATGTATGATGGATCTCGATAATATTCCCGATACG
CAAACGGAAGCTGAAGAGCT

Product: PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC

Products: pyruvate; diacetylchitobiose-6-phosphate [Cytoplasm]; cellobiose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EIIC-Chb; PTS system N,N'-diacetylchitobiose-specific EIIC component

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSFFYSLGIRLDASTIETLNGLK
GIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLLSVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVA
EMFTFIVRRNWVIKLPDSVPASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIF
VPLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDSFIFLGGSGATLGLILAIFIA
SRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIPFVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFF
NTNGSVAALLVALFNLGIATLIYLPFVVVANKAQNAIDKEESEEDIANALKF

Sequences:

>Translated_452_residues
MSNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSFFYSLGIRLDASTIETLNGLK
GIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLLSVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVA
EMFTFIVRRNWVIKLPDSVPASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIF
VPLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDSFIFLGGSGATLGLILAIFIA
SRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIPFVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFF
NTNGSVAALLVALFNLGIATLIYLPFVVVANKAQNAIDKEESEEDIANALKF
>Mature_451_residues
SNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSFFYSLGIRLDASTIETLNGLKG
IGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLLSVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVAE
MFTFIVRRNWVIKLPDSVPASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIFV
PLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDSFIFLGGSGATLGLILAIFIAS
RRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIPFVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFFN
TNGSVAALLVALFNLGIATLIYLPFVVVANKAQNAIDKEESEEDIANALKF

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG1455

COG function: function code G; Phosphotransferase system cellobiose-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-3 domain

Homologues:

Organism=Escherichia coli, GI1788032, Length=452, Percent_Identity=100, Blast_Score=888, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTQC_ECOLI (P17334)

Other databases:

- EMBL:   X52890
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A64933
- PIR:   S10871
- RefSeq:   AP_002356.1
- RefSeq:   NP_416251.1
- ProteinModelPortal:   P17334
- DIP:   DIP-9264N
- STRING:   P17334
- EnsemblBacteria:   EBESCT00000002788
- EnsemblBacteria:   EBESCT00000017812
- GeneID:   945982
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1726
- KEGG:   eco:b1737
- EchoBASE:   EB0139
- EcoGene:   EG10141
- eggNOG:   COG1455
- GeneTree:   EBGT00050000009432
- HOGENOM:   HBG532931
- OMA:   RRNWVIR
- ProtClustDB:   PRK10297
- BioCyc:   EcoCyc:CELB-MONOMER
- Genevestigator:   P17334
- InterPro:   IPR003352
- InterPro:   IPR004796
- InterPro:   IPR004501
- TIGRFAMs:   TIGR00359
- TIGRFAMs:   TIGR00410

Pfam domain/function: PF02378 PTS_EIIC

EC number: NA

Molecular weight: Translated: 48333; Mature: 48202

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS51105 PTS_EIIC_TYPE_3

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x107700e8)-; HASH(0x10de02c4)-; HASH(0x11a656ec)-; HASH(0x101686c4)-; HASH(0x11c980fc)-; HASH(0x11c955f4)-; HASH(0x11c53e70)-; HASH(0x114df774)-; HASH(0x11cdcf00)-; HASH(0x11545ef8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSF
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCCCCE
FYSLGIRLDASTIETLNGLKGIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLL
EEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVAEMFTFIVRRNWVIKLPDSVP
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
ASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHH
FIFLGGSGATLGLILAIFIASRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIP
HEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCHHCCCHHHHHHHHHHH
FVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFFNTNGSVAALLVALFNLGIAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
LIYLPFVVVANKAQNAIDKEESEEDIANALKF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH
>Mature Secondary Structure 
SNVIASLEKVLLPFAVKIGKQPHVNAIKNGFIRLMPLTLAGAMFVLINNVFLSFGEGSF
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCCCCE
FYSLGIRLDASTIETLNGLKGIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDALAAGLL
EEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVAAFMTVTPYSVGEAYAVGANWLGGANIISGIIIGLVVAEMFTFIVRRNWVIKLPDSVP
HHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
ASVSRSFSALIPGFIILSVMGIIAWALNTWGTNFHQIIMDTISTPLASLGSVVGWAYVIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLLWFFGIHGALALTALDNGIMTPWALENIATYQQYGSVEAALAAGKTFHIWAKPMLDS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHCCCEEEEEHHHHHHH
FIFLGGSGATLGLILAIFIASRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIP
HEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCHHCCCHHHHHHHHHHH
FVLVQPILAAITLAAYYMGIIPPVTNIAPWTMPTGLGAFFNTNGSVAALLVALFNLGIAT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
LIYLPFVVVANKAQNAIDKEESEEDIANALKF
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: diacetylchitobiose [Periplasm]; phosphoenolpyruvate; cellobiose [Periplasm] [C]

Specific reaction: phosphoenolpyruvate + diacetylchitobiose [Periplasm] = pyruvate + diacetylchitobiose-6-phosphate [Cytoplasm] phosphoenolpyruvate + cellobiose [Periplasm] = cellobiose-6-phosphate [Cytoplasm] + pyruvate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2179047; 9097039; 9278503; 2092358; 9405618; 10913117