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The map label for this gene is serB

Identifier: 218703136

GI number: 218703136

Start: 5115394

End: 5116362

Strand: Direct

Name: serB

Synonym: ECIAI39_4920

Alternate gene names: 218703136

Gene position: 5115394-5116362 (Clockwise)

Preceding gene: 218703132

Following gene: 218703137

Centisome position: 99.68

GC content: 56.24

Gene sequence:

>969_bases
ATGCCTAACATTACCTGGTGCGACCTGCCTGAAGATGTCTCTTTATGGCCGGGTCTGCCTCTTTCATTAAGTGGTGATGA
AGTGATGCCACTGGATTACCACGCAGGTCGTAGCGGCTGGCTGCTGTATGGTCGTGGGCTGGATAAACAACGTCTGACCC
AATACCAGAGCAAACTGGGCGCGGCTATGGTGATTGTTGCCGCCTGGTGCGTGGAAGATTATCAGGTGATTCGTCTGGCA
GGTTCACTCACCGCGCGGGCTACGCGCTTGGCCCACGAAGCGCAGCTGGATGTCGCGCCGTTGGGGAAAATCCCGCACCT
GCGCTCTCCGGGTTTGCTGGTGATGGACATGGATTCCACCGCCATCCAGATTGAATGTATTGATGAAATTGCCAAACTGG
CCGGAACGGGCGAGATGGTGGCGGAGGTAACCGAACGGGCGATGCGCGGCGAACTCGATTTTACCGCCAGCCTGCGCAGC
CGCGTGGCGACGCTGAAAGGCGCTGACGCCAATATTCTGCAACAGGTGCGTGAAAATCTGCCGCTGATGCCAGGCTTAAC
GCAACTGGTACTCAAGCTGGAAACGCTGGGCTGGAAAGTGGCGATTGCCTCCGGTGGCTTTACTTTCTTTGCTGAATACC
TGCGCGACAAGCTGCGCCTGACAGCCGTGGTAGCCAATGAACTGGAGATCATGGACGGTAAATTTACCGGCAATGTGATC
GGCGACATCGTAGACGCGCAGTACAAAGCGAAAACTCTGACTCGCCTCGCGCAGGAGTATGAAATCCCGCTGGCGCAGAC
CGTGGCGATTGGCGATGGAGCCAATGACCTGCCGATGATCAAAGCGGCAGGGCTGGGGATTGCCTACCATGCCAAGCCAA
AAGTGAATGAAAAAACGGAAGTCACCATCCGTCACGCTGACCTGATGGGGGTATTCTGCATCCTCTCTGGCAGCCTGAAT
CAGAAGTAA

Upstream 100 bases:

>100_bases
ACCCTTTGAAAATTTGAGACTTAATGTTGCCAGAAGCAATGGATACAAGGTAGCCTCATGCGTTATTTTCCCTGCTTCGA
ACGATTTTACAGGAGCCTTA

Downstream 100 bases:

>100_bases
TTGCCTGCCCGTCATCCTGCGGGCGGCACAGCATTAACGAGGTACACCGTGGCAAAAGCTCCAAAACGCGCCTTTGTTTG
TAATGAATGCGGGGCCGATT

Product: phosphoserine phosphatase

Products: NA

Alternate protein names: PSP; PSPase; O-phosphoserine phosphohydrolase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLA
GSLTARATRLAHEAQLDVAPLGKIPHLRSPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRS
RVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKTEVTIRHADLMGVFCILSGSLN
QK

Sequences:

>Translated_322_residues
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLA
GSLTARATRLAHEAQLDVAPLGKIPHLRSPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRS
RVATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKTEVTIRHADLMGVFCILSGSLN
QK
>Mature_321_residues
PNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLGAAMVIVAAWCVEDYQVIRLAG
SLTARATRLAHEAQLDVAPLGKIPHLRSPGLLVMDMDSTAIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSR
VATLKGADANILQQVRENLPLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVIG
DIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKTEVTIRHADLMGVFCILSGSLNQ
K

Specific function: Unknown

COG id: COG0560

COG function: function code E; Phosphoserine phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serB family [H]

Homologues:

Organism=Homo sapiens, GI46249388, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790849, Length=322, Percent_Identity=99.3788819875776, Blast_Score=655, Evalue=0.0,
Organism=Caenorhabditis elegans, GI115534454, Length=236, Percent_Identity=29.6610169491525, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321647, Length=247, Percent_Identity=38.0566801619433, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006383
- InterPro:   IPR023190
- InterPro:   IPR004469 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 35059; Mature: 34928

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLG
CCCCEECCCCCCCCCCCCCCEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHH
AAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRSPGLLVMDMDST
HHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCC
AIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENL
EEEEEEHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
PLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
CCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHH
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKTE
HHHHCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCEEEECCCEEEEECCCCCCCCEE
VTIRHADLMGVFCILSGSLNQK
EEEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLG
CCCEECCCCCCCCCCCCCCEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHH
AAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRSPGLLVMDMDST
HHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCC
AIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENL
EEEEEEHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
PLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
CCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHH
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKTE
HHHHCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCEEEECCCEEEEECCCCCCCCEE
VTIRHADLMGVFCILSGSLNQK
EEEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]