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The map label for this gene is uxuR

Identifier: 218703023

GI number: 218703023

Start: 5002036

End: 5002809

Strand: Direct

Name: uxuR

Synonym: ECIAI39_4797

Alternate gene names: 218703023

Gene position: 5002036-5002809 (Clockwise)

Preceding gene: 218703022

Following gene: 218703026

Centisome position: 97.47

GC content: 53.62

Gene sequence:

>774_bases
ATGAAATCTGCCACCTCTGCGCAAAGACCTTACCAGGAAGTCGGGGCGATGATCCGCGATCTGATCATAAAGACGCCGTA
CAATCCTGGCGAACGGCTGCCGCCGGAGCGTGAAATTGCAGAAATGCTTGATGTCACGCGGACGGTGGTACGTGAAGCGC
TGATCATGCTGGAGATCAAAGGGCTGGTGGAAGTACGCCGGGGTGCCGGTATCTATGTTCTTGATAACTCAGGCAGCCAG
AACACAGACAGTCCGGATGCCAACGTCTGCAACGATGCCGGTCCTTTTGAGCTGTTACAGGCGCGGCAGTTATTGGAGAG
CAACATCGCCGAGTTTGCCGCTTTGCAGGCTACCCGCGAAGATATCGTCAAAATGCGTCAGGCATTGCAACTGGAAGAGC
GTGAACTGGCTTCCAGTGCGCCGGGCAGCAGCGAAAGCGGTGACATGCAGTTCCATCTCGCTATTGCCGAAGCAACGCAT
AACAGCATGCTGGTGGAGCTGTTCCGTCAGTCCTGGCAGTGGCGGGAAAACAATCCAATGTGGATCCAGTTGCACAGCCA
TCTGGATGACAGCCTGTATCGCAAAGAGTGGTTGGGCGATCACAAACAGATCCTCGCCGCGTTAATCAAAAAAGATGCCC
GAGCGGCGAAGCTGGCAATGTGGCAGCATCTGGAAAACGTTAAGCAACGTCTGCTGGAATTCTCGAACGTTGACGATATT
TATTTTGATGGCTATCTGTTTGATTCATGGCCGCTGGATAAAGTCGACGCCTGA

Upstream 100 bases:

>100_bases
GATTAACGGGGGCCGTAAAATTGCCCGTTGTAGGCCGGATAAGGCGTTCACGCCGCATCCGGCAAAAATTTGATTAACCG
CACCTAACGGACACAACACC

Downstream 100 bases:

>100_bases
CTTATTATAATAAGCGCAAGGGTAAACGTTCCTTGCGCTTTCTTAAATTAAGAAGTCGCAATGAGTATTACTTTGTAAAT
TGCAGGGTATTGTTTAGCTA

Product: DNA-binding transcriptional repressor UxuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDNSGSQ
NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH
NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI
YFDGYLFDSWPLDKVDA

Sequences:

>Translated_257_residues
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDNSGSQ
NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH
NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI
YFDGYLFDSWPLDKVDA
>Mature_257_residues
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDNSGSQ
NTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATH
NSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI
YFDGYLFDSWPLDKVDA

Specific function: Repressor for the uxuRBA operon

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790780, Length=257, Percent_Identity=100, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI87082208, Length=255, Percent_Identity=46.2745098039216, Blast_Score=207, Evalue=4e-55,
Organism=Escherichia coli, GI1790032, Length=232, Percent_Identity=30.1724137931034, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786303, Length=228, Percent_Identity=32.8947368421053, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789353, Length=247, Percent_Identity=29.5546558704453, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI48994955, Length=234, Percent_Identity=26.4957264957265, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUR_ECOLI (P39161)

Other databases:

- EMBL:   D13329
- EMBL:   U14003
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S56549
- RefSeq:   AP_004816.1
- RefSeq:   NP_418744.1
- ProteinModelPortal:   P39161
- SMR:   P39161
- DIP:   DIP-11110N
- STRING:   P39161
- EnsemblBacteria:   EBESCT00000003129
- EnsemblBacteria:   EBESCT00000017457
- GeneID:   948849
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW4287
- KEGG:   eco:b4324
- EchoBASE:   EB4151
- EcoGene:   EG20249
- eggNOG:   COG2186
- GeneTree:   EBGT00050000009602
- HOGENOM:   HBG700007
- OMA:   ENIVNRT
- ProtClustDB:   PRK10225
- BioCyc:   EcoCyc:EG20249-MONOMER
- Genevestigator:   P39161
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 29309; Mature: 29309

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLVEVRRGAGIYVLDNSGSQNTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATRE
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNPM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCE
WIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI
EEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
YFDGYLFDSWPLDKVDA
EECCEEECCCCCCCCCC
>Mature Secondary Structure
MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLVEVRRGAGIYVLDNSGSQNTDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATRE
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNPM
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCE
WIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNVDDI
EEEEHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
YFDGYLFDSWPLDKVDA
EECCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503