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The map label for this gene is mutL

Identifier: 218702867

GI number: 218702867

Start: 4836873

End: 4838723

Strand: Direct

Name: mutL

Synonym: ECIAI39_4634

Alternate gene names: 218702867

Gene position: 4836873-4838723 (Clockwise)

Preceding gene: 218702866

Following gene: 218702868

Centisome position: 94.25

GC content: 56.35

Gene sequence:

>1851_bases
TTGATGCCAATTCAGGTCTTACCGCCACAACTGGCGAACCAGATTGCCGCAGGTGAGGTGGTCGAGCGACCTGCGTCGGT
AGTCAAAGAACTGGTGGAAAACAGCCTCGATGCAGGTGCGACGCGTATCGATATTGATATCGAACGTGGCGGGGCGAAAC
TTATCCGCATTCGTGATAACGGCTGCGGTATCAAAAAAGATGAGCTGGCGCTGGCGCTGGCTCGTCATGCCACCAGTAAA
ATCGCCTCTCTGGACGATCTCGAAGCCATTATCAGCCTGGGCTTTCGCGGTGAGGCGCTGGCGAGTATCAGTTCGGTTTC
CCGCCTGACGCTCACTTCACGCACCGCAGAACAGCAGGAAGCCTGGCAGGCCTATGCCGAAGGGCGCGATATGGACGTGA
CGGTTAAACCGGCGGCGCATCCGGTGGGAACGACGCTGGAGGTGCTGGATCTGTTCTACAACACCCCGGCGCGGCGCAAA
TTCCTGCGCACCGAGAAAACCGAATTTAACCACATTGATGAGATCATCCGCCGCATTGCGCTGGCGCGTTTCGACGTCAC
GATCAACCTGTCGCATAACGGGAAAATGGTCCGCCAGTACCGCGCCGTGCCGGAAGGTGGACAAAAAGAGCGCCGTTTAG
GGGCGATTTGCGGCACCGCTTTTCTCGAACAAGCGCTGGCGATTGAATGGCAACACGGCGATCTCACGCTGCGCGGCTGG
GTGGCAGATCCGAATCACACCACGCCCGCACTGGCGGAAATTCAGTATTGCTATGTGAATGGTCGCATGATGCGCGATCG
CCTGATCAATCACGCGATCCGCCAGGCCTGTGAAGACAAACTGGGGGCCGATCAGCAACCGGCATTTGTGTTGTATCTGG
AGATCGACCCACATCAGGTGGACGTCAACGTGCACCCTGCCAAACACGAAGTGCGTTTCCATCAGTCGCGTCTGGTGCAT
GATTTTATCTATCAGGGCGTGCTGAGCGTGCTACAACAGCAACTGGAAACGCCGCTACCGCTGGACGATGAACCCCAACC
TGCACCGCGTGCTATTCCGGAAAACCGCGTGGCGGCGGGGCGCAATCATTTTGCTGAACCGGCAGTTCGTGAGCCAGTAG
CTCCGCGTTACACTCCTGCGCCCGCCTCAGGCAGTCGTCCGGCTGCCCCCTGGCCGAATGCGCAGCCAGGTTACCAGAAA
CAGCAAGGTGAAGTGTATCGCCAGCTTTTGCAAACGCCCGCGCCGATGCAAAAACCAAAAGCGCCAGAACCGCAGGAACC
TGCACTTGCGGCGAACAGTCAGAGTTTTGGTCGGGTACTGACTATCATCCATTCCGACTGTGCGTTGCTGGAGCGCGACG
GAAACATTTCACTTTTAGCCTTGCCAGTGGCAGAACGTTGGCTGCGTCAGGCGCAACTGACGCCGGGTGAAGCGCCAGTT
TGCGCCCAACCGCTGCTTATTCCGTTGCGGCTAAAAGTTTCTGGCGAAGAAAAATCGGCATTAGAAAAAGCGCAGTCTGC
CCTGGCGGAATTGGGTATTGATTTCCAGTCCGATGCGCAGCATGTGACCATCAGGGCCGTGCCTTTACCCTTACGCCAAC
AAAATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTGGCGAAGCAGTCCGTATTCGAACCTGGCAATATTGCGCAG
TGGATTGCACGAAATCTGATGAGCGAACATGCGCAGTGGTCAATGGCACAGGCCATAACCCTGCTGGCGGACGTGGAACG
GTTATGTCCGCAACTTGTGAAAACGCCGCCGGGTGGTCTGTTACAATCTGTTGATTTACATCCGGCGATAAAAGCCCTGA
AAGATGAGTGA

Upstream 100 bases:

>100_bases
TTTCCTTGCGCATCCGATGCAATCTGCGCCGCAGGGTGCAACGGCACAAACTGCCAGTACGGTGACGACGCCAGATCGTA
CGCTGCCAAACTAAGGACGA

Downstream 100 bases:

>100_bases
TATCAGTAAGGCGAGCCTGCCTAAGGCGATTTTTTTGATGGGGCCGACGGCCTCCGGTAAAACGGCGTTAGCCATTGAGC
TGCGTAAAATTTTACCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MMPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSK
IASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRK
FLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKMVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGW
VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVH
DFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQK
QQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIIHSDCALLERDGNISLLALPVAERWLRQAQLTPGEAPV
CAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQ
WIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Sequences:

>Translated_616_residues
MMPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSK
IASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRK
FLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKMVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGW
VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVH
DFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQK
QQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIIHSDCALLERDGNISLLALPVAERWLRQAQLTPGEAPV
CAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQ
WIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
>Mature_616_residues
MMPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSK
IASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRK
FLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKMVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGW
VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVH
DFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQK
QQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIIHSDCALLERDGNISLLALPVAERWLRQAQLTPGEAPV
CAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQ
WIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=31.7610062893082, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI189458898, Length=350, Percent_Identity=30.8571428571429, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.9904153354633, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=26.7267267267267, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=27.027027027027, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=31.0204081632653, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI91992162, Length=362, Percent_Identity=24.8618784530387, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992160, Length=362, Percent_Identity=24.8618784530387, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=23.3898305084746, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790612, Length=615, Percent_Identity=98.6991869918699, Blast_Score=1238, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=329, Percent_Identity=36.7781155015198, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=25.8720930232558, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=340, Percent_Identity=34.7058823529412, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=380, Percent_Identity=27.1052631578947, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=25.1724137931034, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=215, Percent_Identity=29.7674418604651, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.6504559270517, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.3305322128852, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68055; Mature: 68055

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECC
GCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIA
HHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
LARFDVTINLSHNGKMVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGW
HHHEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEE
VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV
ECCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEE
DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCC
RNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPK
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
APEPQEPALAANSQSFGRVLTIIHSDCALLERDGNISLLALPVAERWLRQAQLTPGEAPV
CCCCCCCCCCCCCHHHHHHHHHHHCCHHEEECCCCEEEEEEHHHHHHHHHHCCCCCCCCC
CAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILI
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEH
PELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LQSVDLHPAIKALKDE
HHCCCCCHHHHHHCCC
>Mature Secondary Structure
MMPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECC
GCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIA
HHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHH
LARFDVTINLSHNGKMVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGW
HHHEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEE
VADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQV
ECCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEE
DVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCC
RNHFAEPAVREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPK
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
APEPQEPALAANSQSFGRVLTIIHSDCALLERDGNISLLALPVAERWLRQAQLTPGEAPV
CCCCCCCCCCCCCHHHHHHHHHHHCCHHEEECCCCEEEEEEHHHHHHHHHHCCCCCCCCC
CAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILI
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEH
PELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LQSVDLHPAIKALKDE
HHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA