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The map label for this gene is hemE

Identifier: 218702632

GI number: 218702632

Start: 4582899

End: 4583963

Strand: Direct

Name: hemE

Synonym: ECIAI39_4387

Alternate gene names: 218702632

Gene position: 4582899-4583963 (Clockwise)

Preceding gene: 218702631

Following gene: 218702633

Centisome position: 89.3

GC content: 56.34

Gene sequence:

>1065_bases
ATGACCGAACTTAAAAACGATCGTTATCTGCGGGCGCTGCTGCGCCAGCCCGTTGATGTCACTCCAGTATGGATGATGCG
CCAGGCGGGTCGCTATCTACCGGAATATAAAGCCACGCGCGCCCAGGCGGGCGATTTTATGTCGCTGTGCAAAAACGCCG
AGCTGGCGTGCGAAGTGACTTTGCAACCGCTGCGTCGCTACCCGCTGGATGCGGCGATCCTCTTTTCCGATATCCTCACC
GTGCCGGACGCGATGGGGTTAGGGCTCTATTTTGAAGCCGGAGAAGGTCCGCGTTTTACCTCGCCAGTCACCTGCAAAGC
CGACGTCGATAAACTGCCAATTCCGGACCCGGAAGATGAGCTGGGTTACGTGATGAACGCGGTGCGTACCATTCGTCGCG
AACTGAAAGGCGAAGTGCCGCTGATTGGTTTTTCTGGCAGCCCGTGGACGCTGGCGACCTACATGGTGGAAGGCGGCAGC
AGCAAAGCCTTCACCGTGATCAAAAAAATGATGTATGCCGATCCGCAGGCGCTGCACGCGCTACTCGATAAACTGGCGAA
AAGCGTCACTTTGTATCTGAATGCGCAGATTAAAGCCGGTGCTCAGGCAGTGATGATTTTCGACACCTGGGGCGGCGTGC
TTACCGGGCGCGATTATCAACAGTTCTCGCTCTATTACATGCATAAAATTGTTGATGGTTTACTGCGTGAAAACGACGGT
CGCCGCGTGCCAGTCACGCTGTTTACCAAAGGTGGCGGACAGTGGCTGGAAGCGATGGCAGAAACCGGTTGCGATGCGCT
GGGCCTCGACTGGACAACGGACATCGCCGATGCGCGCCGCCGCGTGGGCAATAAAGTCGCGTTGCAGGGCAATATGGATC
CGTCGATGCTGTATGCGCCGCCTGCCCGCATTGAAGAAGAAGTGGCGTCTATACTTGCAGGTTTCGGTCACGGCGAAGGT
CATGTCTTTAACCTTGGTCACGGCATTCATCAGGATGTGCCGCCAGAACATGCTGGCGTGTTTGTGGAGGCAGTGCATCG
CCTGTCTGCGCCTTATCATCTGTAA

Upstream 100 bases:

>100_bases
CACCGTAGCGCGCCGTCTGATAGAAGATACAGTGGCGATGTGTCGGGCAGAGTATGAGTGATGATACACTGACCGCCTGA
CGCACTAAGGAACAGCCAAA

Downstream 100 bases:

>100_bases
GGAGTGGTTATGGATCTCGCGTCATTACGCGCTCAACAAATCGAACTGGCTTCTTCTGTGATCCGCGAGGATCGACTCGA
TAAAGATCCACCGGATCTGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVASILAGFGHGEG
HVFNLGHGIHQDVPPEHAGVFVEAVHRLSAPYHL

Sequences:

>Translated_354_residues
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILT
VPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVASILAGFGHGEG
HVFNLGHGIHQDVPPEHAGVFVEAVHRLSAPYHL
>Mature_353_residues
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTV
PDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTVIKKMMYADPQALHALLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGR
RVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAPPARIEEEVASILAGFGHGEGH
VFNLGHGIHQDVPPEHAGVFVEAVHRLSAPYHL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=48.4419263456091, Blast_Score=316, Evalue=3e-86,
Organism=Escherichia coli, GI2367337, Length=353, Percent_Identity=99.1501416430595, Blast_Score=725, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=355, Percent_Identity=38.3098591549296, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=42.3631123919308, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=42.3631123919308, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39103; Mature: 38971

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEECCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEEEVASILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSAPYHL
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTVPDAMGLGLYFEAGEGPRFTSPVTCKADVDKLPIPDPEDE
HHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCHH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLAKSVTLYLNAQIKAGAQAVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDG
HHHHHHHHEEEEEEEEECCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGNKVALQGNMDPSMLYAP
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEECC
PARIEEEVASILAGFGHGEGHVFNLGHGIHQDVPPEHAGVFVEAVHRLSAPYHL
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA