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The map label for this gene is mtlR

Identifier: 218702366

GI number: 218702366

Start: 4287738

End: 4288325

Strand: Direct

Name: mtlR

Synonym: ECIAI39_4116

Alternate gene names: 218702366

Gene position: 4287738-4288325 (Clockwise)

Preceding gene: 218702365

Following gene: 218702369

Centisome position: 83.55

GC content: 50.51

Gene sequence:

>588_bases
ATGGTGGACCAGGCGCAGGACACCCTGCGCCCGAATAACAGATTGTCAGATATGCAGGCAACAATGGAACAAACCCAGGC
CTTTGAAAACCGTGTGCTTGAGCGTCTGAATGCTGGCAAAACCGTGCGAAGCTTTCTGATCACCGCCGTCGAGCTTTTGA
CCGAGGCGGTAAATCTTCTGGTGCTTCAGGTATTCCGCAAAGACGATTACGCGGTGAAGTATGCTGTAGAACCGTTACTC
GACGGCGATGGTCCGCTGGGCGATCTTTCTGTGCGTTTAAAACTCATTTACGGGTTGGGCGTCATTAACCGCCAGGAATA
CGAAGATGCGGAACTGCTGATGGCATTGCGTGAAGAGCTAAATCACGACGGCAACGAGTACGCGTTTACCGACGACGAAA
TCCTTGGACCCTTTGGTGAACTGCATTGCGTGGCGGCGTTACCACCGCCGCCACAGTTTGAACCTGCAGACTCCAGTTTG
TATGCAATGCAAATTCAGCGTTACCAACAGGCTGTGCGATCAACAATGGTCCTTTCACTGACAGAGCTGATTTCCAAAAT
CAGCTTAAAAAAAGCCTTTCAAAAGTAA

Upstream 100 bases:

>100_bases
CTGACAAAGGTCCGCAGGCGGCGCTGGCACAGATTTCCGGTCTTGATGCCAACAGCGAGGTTGTATCCGAGGCGGTAACC
GCTTATAAAGCAATGCAATA

Downstream 100 bases:

>100_bases
GTACTTTCGCTTACTTCTCCTCTACCTGTTTCGGCCGATAAAGCCGACGATAATATTCCAGACGTTGTAGATATAACGGC
ACGCTTTCATCAGGTATTCC

Product: mannitol repressor protein

Products: NA

Alternate protein names: Mannitol repressor protein

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLL
DGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSL
YAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK

Sequences:

>Translated_195_residues
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLL
DGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSL
YAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK
>Mature_195_residues
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLLVLQVFRKDDYAVKYAVEPLL
DGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREELNHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSL
YAMQIQRYQQAVRSTMVLSLTELISKISLKKAFQK

Specific function: Acts as a repressor of the mtlAD operon

COG id: COG3722

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yggD

Homologues:

Organism=Escherichia coli, GI1790029, Length=195, Percent_Identity=100, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789297, Length=105, Percent_Identity=36.1904761904762, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLR_ECOL6 (P0AF11)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_756280.1
- ProteinModelPortal:   P0AF11
- SMR:   P0AF11
- EnsemblBacteria:   EBESCT00000045153
- GeneID:   1037649
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c4418
- GeneTree:   EBGT00050000010185
- HOGENOM:   HBG417193
- OMA:   ETQAFEN
- ProtClustDB:   PRK11001
- GO:   GO:0006350
- InterPro:   IPR007761

Pfam domain/function: PF05068 MtlR

EC number: NA

Molecular weight: Translated: 21990; Mature: 21990

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLL
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREEL
HHHHHHCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSLYAMQIQRYQQAVRSTMVLSL
CCCCCCCEECCHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TELISKISLKKAFQK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDQAQDTLRPNNRLSDMQATMEQTQAFENRVLERLNAGKTVRSFLITAVELLTEAVNLL
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VLQVFRKDDYAVKYAVEPLLDGDGPLGDLSVRLKLIYGLGVINRQEYEDAELLMALREEL
HHHHHHCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
NHDGNEYAFTDDEILGPFGELHCVAALPPPPQFEPADSSLYAMQIQRYQQAVRSTMVLSL
CCCCCCCEECCHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TELISKISLKKAFQK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157