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The map label for this gene is ttdA

Identifier: 218701832

GI number: 218701832

Start: 3710771

End: 3711682

Strand: Direct

Name: ttdA

Synonym: ECIAI39_3557

Alternate gene names: 218701832

Gene position: 3710771-3711682 (Clockwise)

Preceding gene: 218701830

Following gene: 218701833

Centisome position: 72.31

GC content: 54.28

Gene sequence:

>912_bases
ATGATGAGCGAAAGTAATAAGCAACAGGCAGTGAATAAGTTGACGGAGATTGTCGCTAACTTTACCGCCATGATTTCTAC
CCGAATGCCTGATGACGTGGTGGATAAACTAAAACAGCTAAAGGATGCCGAAACGTCGTCGATGGGGAAAATTATCTACC
ATACGATGTTCGACAACATGCAAAAAGCGATTGACCTGAATCGTCCTGCCTGTCAGGACACCGGGGAGATTATGTTCTTC
GTTAAAGTCGGTTCCCGCTTCCCACTGCTTGGCGAGCTGCAAAGCATACTCAAACAAGCCGTGGAAGAGGCAACCGTCAA
AGCGCCACTACGTCACAATGCGGTAGAAATTTTTGACGAAGTGAACACAGGCAAAAATACCGGCAGCGGCGTACCGTGGG
TCACCTGGGATATCGTCCCCGACGGTGACGATGCGGAAATCGAAGTTTACATGGCAGGCGGCGGCTGCACGCTACCAGGC
CGCTCGAAAGTGTTAATGCCGTCAGAAGGCTACGAAGGCGTGGTGAAATTCGTCTTCGAAAATATCTCCACCCTCGCCGT
AAACGCCTGTCCACCGGTACTGGTGGGCGTGGGCATCGCCACCTCGGTGGAAACCGCCGCCGTACTCTCGCGTAAAGCCA
TTTTGCGCCCGATTGGCAGCCGCCATCCCAATCCAAAAGCGGCAGAACTGGAGCTACGCCTGGAAGAAGGACTCAACCGT
CTGGGGATTGGTCCACAAGGGCTGACCGGCAACAGTTCAGTGATGGGCGTACATATCGAATCTGCCGCCCGCCATCCGTC
AACCATCGGCGTTGCTGTCTCTACCGGCTGCTGGGCGCATCGTCGCGGCACGCTGCTGGTTCATGCCGATCTCACCTTTG
AAAATCTGTCTCACACCCGGAGCGCGTTATGA

Upstream 100 bases:

>100_bases
TTAATTACATATTCACGGTGGCAAAAAATATAAAACCACATTTTTAGTGGTAGTTTGTGGCGGTGAATTTTTCCAGACAA
ATACATAAACTGGAGTTGCC

Downstream 100 bases:

>100_bases
AAAAGATCCTGACAACCCCGATCAAAGCTGAAGATCTGCAAGATATTCGCGTCGGCGATGTGATCTACCTGACCGGTACG
CTGGTGACCTGCCGCGACGT

Product: tartrate dehydratase subunit alpha

Products: NA

Alternate protein names: L-TTD alpha [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFF
VKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPG
RSKVLMPSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTRSAL

Sequences:

>Translated_303_residues
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFF
VKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPG
RSKVLMPSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTRSAL
>Mature_303_residues
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFF
VKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPG
RSKVLMPSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTRSAL

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=303, Percent_Identity=99.3399339933993, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI1790564, Length=258, Percent_Identity=27.5193798449612, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787897, Length=258, Percent_Identity=27.1317829457364, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646 [H]

Pfam domain/function: PF05681 Fumerase [H]

EC number: =4.2.1.32 [H]

Molecular weight: Translated: 32663; Mature: 32663

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDE
HHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
VNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFE
HCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
NISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
HHHHEEECCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHCHHH
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTR
HCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHHHHHHH
SAL
HCC
>Mature Secondary Structure
MMSESNKQQAVNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDE
HHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
VNTGKNTGSGVPWVTWDIVPDGDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFE
HCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
NISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNR
HHHHEEECCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHCHHH
LGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLTFENLSHTR
HCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHHHHHHH
SAL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]