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The map label for this gene is hflC [H]

Identifier: 218701645

GI number: 218701645

Start: 3508678

End: 3509622

Strand: Direct

Name: hflC [H]

Synonym: ECIAI39_3353

Alternate gene names: 218701645

Gene position: 3508678-3509622 (Clockwise)

Preceding gene: 218701638

Following gene: 218701647

Centisome position: 68.37

GC content: 48.89

Gene sequence:

>945_bases
GTGACATATTCCCCACTTTACTCAAGGAAGATTCATATGAAAGCACCTGTTTCATTAACCTCATTTCGCCCACAAAAATC
TCTTGCTATCGCCATTGGCGTGCTTGCCGTGGTTGTGCTGCCATTTCTCTCGTATTACACCGTTAATGAAGGTGAACGCG
GCATTTTGCTGCGCTACGGAAAAATCGTAAAAGTTGCCGAGCCGGGTCTGGGTTTTAAGATCCCGTTTATGGAAAGCGTG
GAGAAAATTTCCACGCGTAATCAGGCTGTGGTCTATCAGGGATTACAGGCCTACAGCCGCGACCAGCAACCGGCACAAAT
GACAGTATCAGTCATCTTCCACATTAAACCTTCAGAAGCAGGCGCGGTTTATACCACCTACAACACCATTGAAGCATTAA
AAGATCGTCTGATTGTCCGTCAGTTGCCAACTCAACTGGAGAACGTTTTCGGCCAATATACCGCCATCAGCGCGGTACAG
GATCGTACAAAACTGGTTCAGGATCTGCAAAATGCCATGCGCAAAGCCGTTGTTGGGCCAGTGGTAATTGACGGGGTCCA
GATTGAAAATATTGATTTTTCTGACGCTTATGAAAAGTCGATTGAAGACCGAATGAAAGCAGAAGTCGCCATTGCCACGC
GTAAGCAAAATCTGGAAACAGAGAAAATCCAGGCGCAAATAGCGGTAACTCAGGCCCAGGCAGAAGCAGACAGTAAACTG
GCGGCAGCTAAAGCAGAAGCGGAAACTATTCGCGTAAGAGGCGCGGCAGAGGCTGAAACTATTCGTTTAAAAAGTGCGGC
TGAAGCAGAAGCGATCCGCCTGCGCGGTGAAGCTCTGCGGGATAATCCCGGACTTGTAGCCCTCACCACTGCCGAACGTT
GGGACGGTAAACTGCCCGATACCATGATCCCCGGCAGCACAGTTCCGTTTATCTCTACTAAGTAA

Upstream 100 bases:

>100_bases
TGAATATCCGAAAACATACTTTTTTAATGCAACGTTTTTTCGCTATACCCCTTTATAGATTCTGAATTCTCACCTGTCGG
CTATTTTCTCCTTACCTCAT

Downstream 100 bases:

>100_bases
AAAAAGGGCCGCTTTCGCGGCCCTTCTCACAAAGCATCTTACCGATTACAGCAGTTCTTTTGCTTTCGCAACAACGTTGT
CAACGGTGAAGCCGAACTCT

Product: putative membrane protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTYSPLYSRKIHMKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILLRYGKIVKVAEPGLGFKIPFMESV
EKISTRNQAVVYQGLQAYSRDQQPAQMTVSVIFHIKPSEAGAVYTTYNTIEALKDRLIVRQLPTQLENVFGQYTAISAVQ
DRTKLVQDLQNAMRKAVVGPVVIDGVQIENIDFSDAYEKSIEDRMKAEVAIATRKQNLETEKIQAQIAVTQAQAEADSKL
AAAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAERWDGKLPDTMIPGSTVPFISTK

Sequences:

>Translated_314_residues
MTYSPLYSRKIHMKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILLRYGKIVKVAEPGLGFKIPFMESV
EKISTRNQAVVYQGLQAYSRDQQPAQMTVSVIFHIKPSEAGAVYTTYNTIEALKDRLIVRQLPTQLENVFGQYTAISAVQ
DRTKLVQDLQNAMRKAVVGPVVIDGVQIENIDFSDAYEKSIEDRMKAEVAIATRKQNLETEKIQAQIAVTQAQAEADSKL
AAAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAERWDGKLPDTMIPGSTVPFISTK
>Mature_313_residues
TYSPLYSRKIHMKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILLRYGKIVKVAEPGLGFKIPFMESVE
KISTRNQAVVYQGLQAYSRDQQPAQMTVSVIFHIKPSEAGAVYTTYNTIEALKDRLIVRQLPTQLENVFGQYTAISAVQD
RTKLVQDLQNAMRKAVVGPVVIDGVQIENIDFSDAYEKSIEDRMKAEVAIATRKQNLETEKIQAQIAVTQAQAEADSKLA
AAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAERWDGKLPDTMIPGSTVPFISTK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=301, Percent_Identity=24.2524916943522, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 34541; Mature: 34410

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSPLYSRKIHMKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILLRYG
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEC
KIVKVAEPGLGFKIPFMESVEKISTRNQAVVYQGLQAYSRDQQPAQMTVSVIFHIKPSEA
CEEEEECCCCCEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCC
GAVYTTYNTIEALKDRLIVRQLPTQLENVFGQYTAISAVQDRTKLVQDLQNAMRKAVVGP
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VVIDGVQIENIDFSDAYEKSIEDRMKAEVAIATRKQNLETEKIQAQIAVTQAQAEADSKL
EEECCEEEECCCCHHHHHHHHHHHHHHHHEEEHHHCCCCHHHHHEEHEEHHHHHHHHHHH
AAAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAERWDGKLPD
HHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCHHHCCCCCEEEEEECHHCCCCCCC
TMIPGSTVPFISTK
CCCCCCCCCCEECC
>Mature Secondary Structure 
TYSPLYSRKIHMKAPVSLTSFRPQKSLAIAIGVLAVVVLPFLSYYTVNEGERGILLRYG
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEC
KIVKVAEPGLGFKIPFMESVEKISTRNQAVVYQGLQAYSRDQQPAQMTVSVIFHIKPSEA
CEEEEECCCCCEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCC
GAVYTTYNTIEALKDRLIVRQLPTQLENVFGQYTAISAVQDRTKLVQDLQNAMRKAVVGP
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VVIDGVQIENIDFSDAYEKSIEDRMKAEVAIATRKQNLETEKIQAQIAVTQAQAEADSKL
EEECCEEEECCCCHHHHHHHHHHHHHHHHEEEHHHCCCCHHHHHEEHEEHHHHHHHHHHH
AAAKAEAETIRVRGAAEAETIRLKSAAEAEAIRLRGEALRDNPGLVALTTAERWDGKLPD
HHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHCCHHHCCCCCEEEEEECHHCCCCCCC
TMIPGSTVPFISTK
CCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]