BacMap

Definition	Escherichia coli IAI39 chromosome, complete genome.
Accession	NC_011750
Length	5,132,068

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The map label for this gene is cysA [C]

Identifier: 218701638

GI number: 218701638

Start: 3502301

End: 3503011

Strand: Direct

Name: cysA [C]

Synonym: ECIAI39_3346

Alternate gene names: 218701638

Gene position: 3502301-3503011 (Clockwise)

Preceding gene: 218701637

Following gene: 218701645

Centisome position: 68.24

GC content: 53.45

Gene sequence:

>711_bases
GTGGCAATTGCAAAACGGAGCGCTCCAGCCACTATGTTAACGTTAAATCAGATAACTTATCGCTGGCCTGGCGCGGCAAC
GGATTGTCTTTGCGACATTTCTCTGCAACTCAAACAAGGTGAATGGTTGGCGCTGACCGGCGACAATGGCGCGGGAAAAT
CGACGCTGTTACGAGTAATGGCAGGTCTTCTTACGCCCACAACCAGTACGGTTATGCTGCAACAACAGGCGATGAAAAAC
CTGAAAAACCGCCAACGTGCAGCAAAGATTGGCGTACTGTTTCAGGAAGCGGAAAACCAGCTTTTTCACAGCACCGTCGC
CGACGAGATCGCATTTGGTTTGAAACTGCAAAAATGCCCGGCGGATGAAATCACTCAACGTACCAATGCTGCCCTGCAAT
GCTGTCAGTTAGCAGACACTGCCAGCGCGCATCCGCTGGATCTGCATAGTGCGCAGCGACGGATGGTCGCCGTCGCCTGC
CTGGAAGCACTCTCTCCGCCGCTATTGCTGCTGGACGAGCCGAGTCGGGATTTTGACGAAAATTGGTTGAGCGTGTTTGA
ACGCTGGCTGGAAAAGTGCCGCCAGCGAGGCACGAGCGTCGTAGCAATCAGTCATGACGCCGCATTTACCCGGCGTCATT
TCTCTCGTGTGGTGCGACTGGAAGATGGTGTAATCAGGAACGTTAATCCACCAGACGATATTCACCCGTAG

Upstream 100 bases:

>100_bases
TGCTGTTGCAGCGCTTACAACACTGGGCGTCTGAACGTGGTTCGCTGATTATTCTTTTTGAACGTCATCGCACACCTTTC
CTGAACTACTGCCAGCAAGC

Downstream 100 bases:

>100_bases
CGGTCATCATTAAGGTCAAATTTGCAGGCAGACTCTCTTCCAGCACCCGGCGAACATTCGGCCCGTCGGTACGGTCATAA
AAGTCTTCTGCGTCTGCCAG

Product: putative ATP-binding protein of ABC transport system

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MAIAKRSAPATMLTLNQITYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTLLRVMAGLLTPTTSTVMLQQQAMKN
LKNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCPADEITQRTNAALQCCQLADTASAHPLDLHSAQRRMVAVAC
LEALSPPLLLLDEPSRDFDENWLSVFERWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDDIHP

Sequences:

>Translated_236_residues
MAIAKRSAPATMLTLNQITYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTLLRVMAGLLTPTTSTVMLQQQAMKN
LKNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCPADEITQRTNAALQCCQLADTASAHPLDLHSAQRRMVAVAC
LEALSPPLLLLDEPSRDFDENWLSVFERWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDDIHP
>Mature_235_residues
AIAKRSAPATMLTLNQITYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTLLRVMAGLLTPTTSTVMLQQQAMKNL
KNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCPADEITQRTNAALQCCQLADTASAHPLDLHSAQRRMVAVACL
EALSPPLLLLDEPSRDFDENWLSVFERWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDDIHP

Specific function: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system [H]

COG id: COG1118

COG function: function code P; ABC-type sulfate/molybdate transport systems, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI4505771, Length=232, Percent_Identity=27.1551724137931, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI9961252, Length=232, Percent_Identity=27.1551724137931, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI9961250, Length=239, Percent_Identity=26.3598326359833, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI42741659, Length=221, Percent_Identity=27.6018099547511, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI255708477, Length=224, Percent_Identity=25, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1788761, Length=215, Percent_Identity=35.3488372093023, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081791, Length=233, Percent_Identity=33.0472103004292, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87081834, Length=214, Percent_Identity=32.2429906542056, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787370, Length=212, Percent_Identity=33.0188679245283, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789873, Length=215, Percent_Identity=29.3023255813954, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790467, Length=225, Percent_Identity=28.8888888888889, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789032, Length=208, Percent_Identity=29.3269230769231, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786398, Length=207, Percent_Identity=29.4685990338164, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI87082267, Length=225, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790739, Length=210, Percent_Identity=30.4761904761905, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787029, Length=224, Percent_Identity=26.3392857142857, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI87081709, Length=227, Percent_Identity=25.9911894273128, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788225, Length=206, Percent_Identity=28.1553398058252, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787712, Length=205, Percent_Identity=27.3170731707317, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790525, Length=202, Percent_Identity=28.2178217821782, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787089, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786253, Length=220, Percent_Identity=30.4545454545455, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48995001, Length=190, Percent_Identity=29.4736842105263, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789891, Length=232, Percent_Identity=28.448275862069, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1789672, Length=230, Percent_Identity=25.2173913043478, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786803, Length=212, Percent_Identity=26.8867924528302, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787164, Length=217, Percent_Identity=29.9539170506912, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788210, Length=201, Percent_Identity=30.3482587064677, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790190, Length=206, Percent_Identity=25.2427184466019, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788472, Length=221, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788897, Length=209, Percent_Identity=28.2296650717703, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787759, Length=243, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787105, Length=227, Percent_Identity=26.431718061674, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786872, Length=229, Percent_Identity=27.0742358078603, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788506, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787792, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786345, Length=236, Percent_Identity=27.5423728813559, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789864, Length=241, Percent_Identity=24.896265560166, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786703, Length=201, Percent_Identity=27.363184079602, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786698, Length=214, Percent_Identity=26.1682242990654, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787500, Length=211, Percent_Identity=26.0663507109005, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787547, Length=205, Percent_Identity=22.9268292682927, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788450, Length=210, Percent_Identity=25.7142857142857, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788644, Length=235, Percent_Identity=22.9787234042553, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558664, Length=229, Percent_Identity=23.5807860262009, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=230, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=230, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=230, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17543740, Length=223, Percent_Identity=22.8699551569507, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=187, Percent_Identity=25.668449197861, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=229, Percent_Identity=23.1441048034935, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=228, Percent_Identity=25.4385964912281, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=217, Percent_Identity=22.1198156682028, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593
- InterPro:   IPR022112 [H]

Pfam domain/function: PF00005 ABC_tran; PF12370 CoABC_C [H]

EC number: 3.6.3.25 [C]

Molecular weight: Translated: 26158; Mature: 26027

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAKRSAPATMLTLNQITYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTLLRVM
CCCCCCCCCCCEEEECCEEEECCCCCCHHEEEEEEEEECCCEEEEECCCCCCHHHHHHHH
AGLLTPTTSTVMLQQQAMKNLKNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
ADEITQRTNAALQCCQLADTASAHPLDLHSAQRRMVAVACLEALSPPLLLLDEPSRDFDE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
NWLSVFERWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDDIHP
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCEECCCCCCCCCCC
>Mature Secondary Structure 
AIAKRSAPATMLTLNQITYRWPGAATDCLCDISLQLKQGEWLALTGDNGAGKSTLLRVM
CCCCCCCCCCEEEECCEEEECCCCCCHHEEEEEEEEECCCEEEEECCCCCCHHHHHHHH
AGLLTPTTSTVMLQQQAMKNLKNRQRAAKIGVLFQEAENQLFHSTVADEIAFGLKLQKCP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
ADEITQRTNAALQCCQLADTASAHPLDLHSAQRRMVAVACLEALSPPLLLLDEPSRDFDE
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
NWLSVFERWLEKCRQRGTSVVAISHDAAFTRRHFSRVVRLEDGVIRNVNPPDDIHP
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]