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The map label for this gene is srlR

Identifier: 218701197

GI number: 218701197

Start: 2999499

End: 3000272

Strand: Direct

Name: srlR

Synonym: ECIAI39_2893

Alternate gene names: 218701197

Gene position: 2999499-3000272 (Clockwise)

Preceding gene: 218701196

Following gene: 218701198

Centisome position: 58.45

GC content: 48.45

Gene sequence:

>774_bases
ATGAAACCTCGTCAGCGTCAGGCCGCCATTCTGGAGTATCTGCAAAAGCAGGGTAAATGCTCGGTTGAAGAATTGGCGCA
ATACTTTGACACCACAGGCACAACCATTCGCAAAGATCTGGTCATTCTGGAACATGCCGGAACCGTCATTCGTACTTATG
GCGGAGTGGTGTTGAATAAAGAGGAATCCGATCCGCCTATCGATCATAAAACACTCATCAACACCCACAAGAAAGAGCTG
ATTGCAGAAGCTGCCGTTAGTTTTATCCATGATGGCGATTCGATCATTCTTGATGCTGGCAGTACCGTTTTGCAGATGGT
TCCCCTGCTCTCGCGCTTTAATAACATCACAGTGATGACCAACAGCCTGCATATCGTCAATGCGCTATCCGAACTGGATA
ACGAACAAACGATCCTGATGCCAGGCGGAACATTTCGTAAAAAATCGGCCTCATTTCACGGGCAACTGGCAGAGAATGCC
TTCGAGCATTTCACCTTCGATAAATTGTTTATGGGCACCGACGGCATCGATCTCAATGCGGGCGTAACCACGTTCAACGA
GGTTTATACCGTCAGTAAGGCAATGTGCAATGCCGCGCGCGAAGTGATTTTGATGGCGGACTCATCAAAGTTTGGCCGTA
AAAGCCCCAACGTAGTTTGCAGTCTTGAAAGCGTCGATAAGCTAATTACCGACGCAGGTATCGATCCGGCGTTTCGTCAG
GCGCTGGAAAAGAAAGGGATCGATGTGATCATAACCGGAGAGAGCAATGAGTGA

Upstream 100 bases:

>100_bases
TCTATCATTGGCGCTTAAACTGAAACGTGGATAATTTCGTTGTGAATGTTACTTGCTTGCGAAGTTATCATTTTGAAACC
TAAATCAGGTAATCACGCCC

Downstream 100 bases:

>100_bases
AGCACTACTGAACGCGGGACGTCAGACGTTAATGCTGGAGTTACAGGAAGCAAGCCGTTTACCGGAACGTCTGGGCGATG
ATTTTGTTCGCGCCGCCAAT

Product: DNA-binding transcriptional repressor SrlR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEKKGIDVIITGESNE

Sequences:

>Translated_257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEKKGIDVIITGESNE
>Mature_257_residues
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL
IAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA
FEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
ALEKKGIDVIITGESNE

Specific function: Unknown

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=257, Percent_Identity=99.6108949416342, Blast_Score=529, Evalue=1e-152,
Organism=Escherichia coli, GI1789519, Length=254, Percent_Identity=35.8267716535433, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789829, Length=234, Percent_Identity=30.7692307692308, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI226510968, Length=253, Percent_Identity=29.6442687747036, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788069, Length=234, Percent_Identity=31.1965811965812, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082344, Length=254, Percent_Identity=27.1653543307087, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790753, Length=251, Percent_Identity=28.2868525896414, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787540, Length=232, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790635, Length=257, Percent_Identity=24.5136186770428, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789170, Length=231, Percent_Identity=27.7056277056277, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787063, Length=231, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28236; Mature: 28236

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNK
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEEHHCCEEEEC
EESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
NSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNA
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHEECCCCCCCCC
GVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
CCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHH
ALEKKGIDVIITGESNE
HHHHCCCEEEEECCCCC
>Mature Secondary Structure
MKPRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNK
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEEHHCCEEEEC
EESDPPIDHKTLINTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
NSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNA
CCHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHEECCCCCCCCC
GVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITDAGIDPAFRQ
CCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHCCCCHHHHH
ALEKKGIDVIITGESNE
HHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3062173; 9278503; 9205837 [H]