BacMap

Definition	Escherichia coli IAI39 chromosome, complete genome.
Accession	NC_011750
Length	5,132,068

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The map label for this gene is ccmA

Identifier: 218700670

GI number: 218700670

Start: 2409800

End: 2410423

Strand: Reverse

Name: ccmA

Synonym: ECIAI39_2339

Alternate gene names: 218700670

Gene position: 2410423-2409800 (Counterclockwise)

Preceding gene: 218700671

Following gene: 218700669

Centisome position: 46.97

GC content: 55.93

Gene sequence:

>624_bases
GTGGGTATGCTTGAAGCCAGAGAGTTACTTTGCGAGCGGGATGAACGAACCTTATTTAGTGGCTTGTCATTTACGCTGAA
CGCAGGAGAGTGGGTACAAATCACCGGTAGCAACGGCGCGGGGAAGACAACGCTTCTCCGTTTGCTGACGGGGTTGTCTC
GCCCTGATGCGGGTGACGTTCTCTGGCAAGGGCAGCCCTTGCATCAGGTACGCGAGAGCTACCATCAAAACCTGTTATGG
ATAGGGCATCAGCCGGGGATCAAAACCCGGCTGACGGCGTTAGAAAATCTGCACTTTTATCATCGCGATGGCGATACCGC
ACAATGTCTGGAAGCCCTGGCGCAGGCCGGGCTTGCCGGATTCGAAGATATTCCGGTAAATCAACTTTCTGCCGGGCAAC
AACGCCGCGTCGCTTTAGCGCGTCTGTGGCTGACCCGTGCCACGTTATGGATACTCGACGAGCCTTTTACCGCGATTGAC
GTTAACGGCGTCGATCGTCTGACCCAGCGTATGGCGCAGCATACGGAGCAGGGGGGGACTGTGATTCTGACTACCCACCA
GCCGCTCAACGTTGCTGAAAGTAAAATTCGCCGCATTTCACTGACGCAAACGGGGGCCGCATGA

Upstream 100 bases:

>100_bases
GGTGAAAGATGGGCAAACCTGTATTGATTGCCATAAAGGGATAGCGCACAAGCTGCCCGATATGCGCGAAGTCGAGCCAG
GTTTTTAACAGGGTTATTGC

Downstream 100 bases:

>100_bases
TGTTCTGGCGCATTTTCCGTCTTGAGCTGCGCGTAGCGTTTCGCCATAGCGCCGAAATCGCCAACCCGCTGTGGTTCTTC
CTGATTGTCATTACCCTTTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRESYHQNLLW
IGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID
VNGVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA

Sequences:

>Translated_207_residues
MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRESYHQNLLW
IGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAID
VNGVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA
>Mature_206_residues
GMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDVLWQGQPLHQVRESYHQNLLWI
GHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDV
NGVDRLTQRMAQHTEQGGTVILTTHQPLNVAESKIRRISLTQTGAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=205, Percent_Identity=29.7560975609756, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=28.7735849056604, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI9665248, Length=194, Percent_Identity=30.9278350515464, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI27477115, Length=214, Percent_Identity=28.0373831775701, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI73747915, Length=215, Percent_Identity=27.4418604651163, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI105990541, Length=191, Percent_Identity=28.7958115183246, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27881501, Length=195, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30795238, Length=195, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI255708477, Length=207, Percent_Identity=28.5024154589372, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592971, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592956, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592915, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592898, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592978, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI46592964, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI73747917, Length=161, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI148612844, Length=207, Percent_Identity=28.5024154589372, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI42741659, Length=192, Percent_Identity=26.5625, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI21536376, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4505771, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI31657092, Length=198, Percent_Identity=26.7676767676768, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI9961252, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI45446740, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI47078218, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI150417984, Length=190, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=207, Percent_Identity=98.0676328502416, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=30.2884615384615, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=30.7228915662651, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1788225, Length=203, Percent_Identity=29.064039408867, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081791, Length=191, Percent_Identity=30.8900523560209, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787370, Length=181, Percent_Identity=30.3867403314917, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787041, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1789891, Length=205, Percent_Identity=30.7317073170732, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786703, Length=188, Percent_Identity=31.3829787234043, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1788165, Length=153, Percent_Identity=33.9869281045752, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787029, Length=198, Percent_Identity=28.2828282828283, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788897, Length=204, Percent_Identity=29.9019607843137, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI48994943, Length=208, Percent_Identity=27.8846153846154, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI48995001, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789593, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789032, Length=198, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1787164, Length=194, Percent_Identity=32.4742268041237, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787105, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789991, Length=154, Percent_Identity=30.5194805194805, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786698, Length=176, Percent_Identity=27.8409090909091, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1786345, Length=191, Percent_Identity=31.413612565445, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790190, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787112, Length=178, Percent_Identity=30.3370786516854, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789873, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787547, Length=178, Percent_Identity=29.2134831460674, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790544, Length=192, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786563, Length=196, Percent_Identity=29.5918367346939, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1788210, Length=180, Percent_Identity=26.1111111111111, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787113, Length=204, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788450, Length=174, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788644, Length=196, Percent_Identity=28.0612244897959, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789586, Length=197, Percent_Identity=25.8883248730964, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=145, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786398, Length=183, Percent_Identity=28.9617486338798, Blast_Score=61, Evalue=4e-11,
Organism=Escherichia coli, GI1786975, Length=184, Percent_Identity=27.7173913043478, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=187, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533608, Length=197, Percent_Identity=28.4263959390863, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25146777, Length=186, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17543740, Length=206, Percent_Identity=25.7281553398058, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193211017, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193211015, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71996809, Length=186, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=186, Percent_Identity=25.8064516129032, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=188, Percent_Identity=27.1276595744681, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=186, Percent_Identity=27.9569892473118, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=193, Percent_Identity=27.4611398963731, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=193, Percent_Identity=26.9430051813472, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17533971, Length=193, Percent_Identity=24.8704663212435, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=193, Percent_Identity=26.9430051813472, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=186, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=170, Percent_Identity=30.5882352941176, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533592, Length=193, Percent_Identity=27.4611398963731, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=193, Percent_Identity=25.9067357512953, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=190, Percent_Identity=27.8947368421053, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=164, Percent_Identity=26.8292682926829, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=192, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=208, Percent_Identity=25.9615384615385, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=27.3224043715847, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=27.3224043715847, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28574744, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007184, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221500365, Length=181, Percent_Identity=32.5966850828729, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574533, Length=186, Percent_Identity=26.8817204301075, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24666092, Length=172, Percent_Identity=27.3255813953488, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648314, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641342, Length=179, Percent_Identity=30.1675977653631, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17136662, Length=188, Percent_Identity=28.7234042553192, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550390, Length=175, Percent_Identity=27.4285714285714, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22942; Mature: 22811

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDV
CCCHHHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
LWQGQPLHQVRESYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAG
EECCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC
FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGT
CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHHCCCCE
VILTTHQPLNVAESKIRRISLTQTGAA
EEEEECCCCHHHHHHHHEEECCCCCCC
>Mature Secondary Structure 
GMLEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGDV
CCHHHHHHHHCCHHHHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
LWQGQPLHQVRESYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAG
EECCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCC
FEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGT
CCCCCCHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEECCCHHHHHHHHHHHHCCCCE
VILTTHQPLNVAESKIRRISLTQTGAA
EEEEECCCCHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]