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The map label for this gene is astC

Identifier: 218699685

GI number: 218699685

Start: 1371541

End: 1372761

Strand: Direct

Name: astC

Synonym: ECIAI39_1306

Alternate gene names: 218699685

Gene position: 1371541-1372761 (Clockwise)

Preceding gene: 218699675

Following gene: 218699686

Centisome position: 26.72

GC content: 55.36

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTGATGAATGGATGATACCTGTTTACGCCCCGGCACCGTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAGGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCCCTAAAACTGGCGCGTAAATTCGCTCACGACCGCTACGGCTGCCATAAGAGCGGCATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGCGGTCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCGCCGGATATTCGTCATGCCGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACTCTACCTGTGCGGT
GATTGTCGAACCCATCCAGGGCGAAGGCGGTGTGGTGCCAGCCAGCAACGCGTTTTTACATGGTCTGCGTGAATTGTGTG
ACCGCCACAATGCATTGCTGATTTTTGATGAAGTACAAACCGGCGTCGGGCGCACCGGGGAACTGTATGCATATATGCAC
TACGGCGTGACGCCCGATCTGTTAACTACCGCCAAAGCGCTGGGCGGCGGTTTCCCGGTCGGTGCGTTATTGGCAACCGA
AGAGTGCGCCAGCGTGATGACCGTTGGCACTCACGGCACCACCTATGGCGGTAATCCGCTGGCCTCGGCGGTGGCGGGCA
AAGTGCTGGATCTCATTAACACGCCAGAGATGCTTAACGGGGTTAAGCAGCGTCACGACTGGTTTGTTGAGCGTCTTAAT
ACCGTTAATCACCGCTGCGGTTTGTTCAGTGAAATTCGTGGATTAGGTTTGTTGATTGGCTGTGTACTGAATGCCGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAAGCGGCGAAAGCAGGCGTGATGGTACTGATTGCGGGTGGCAACGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTATTAACATATAAATAACGAAT
TATTTACTGCAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGTTCAGATGTCTCGGCGCTGATGCAGCTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGCHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
TVNHRCGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGCHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLN
TVNHRCGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS
>Mature_405_residues
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGCHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PPDIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLINTPEMLNGVKQRHDWFVERLNT
VNHRCGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.5646437994723, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.1535836177474, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=26.86230248307, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.7251184834123, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=27.0142180094787, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.906976744186, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=26.603325415677, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI188536080, Length=433, Percent_Identity=23.7875288683603, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679950, Length=433, Percent_Identity=23.7875288683603, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679946, Length=433, Percent_Identity=23.7875288683603, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=97.7832512315271, Blast_Score=821, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=60.2015113350126, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=33.4170854271357, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=35.0267379679144, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.6153846153846, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=32.1428571428571, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.4324324324324, Blast_Score=124, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.0383631713555, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.4252873563218, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=286, Percent_Identity=33.5664335664336, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=29.0993071593533, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=34.5454545454545, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=26.2987012987013, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=39.8009950248756, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=400, Percent_Identity=33.5, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.9230769230769, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=25.6830601092896, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=35.3562005277045, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.2035398230088, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.2134831460674, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=28.808864265928, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=23.7762237762238, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=23.7762237762238, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=23.7762237762238, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43575; Mature: 43443

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGCHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTVNHRCGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFDEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGCHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHEE
DDSTCAVIVEPIQGEGGVVPASNAFLHGLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECASVMTVGTHGTTYGGNPLASAVAGKVLDLIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTVNHRCGLFSEIRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA