Click here to switch to the map view.

The map label for this gene is pgsA

Identifier: 218699524

GI number: 218699524

Start: 1214072

End: 1214620

Strand: Direct

Name: pgsA

Synonym: ECIAI39_1143

Alternate gene names: 218699524

Gene position: 1214072-1214620 (Clockwise)

Preceding gene: 218699523

Following gene: 218699525

Centisome position: 23.66

GC content: 52.28

Gene sequence:

>549_bases
ATGCAATTTAATATCCCTACGTTGCTTACACTGTTCCGTGTCATCCTTATCCCATTCTTTGTATTGGTCTTTTATCTGCC
TGTCACCTGGTCGCCGTTTGCCGCCGCGCTCATTTTCTGCGTCGCGGCGGTGACTGACTGGTTCGATGGTTTTCTGGCAC
GCCGCTGGAACCAGAGTACCCGGTTTGGTGCTTTCCTTGACCCTGTAGCAGATAAAGTTCTCGTGGCTATCGCCATGGTG
CTGGTAACCGAGCATTATCACAGCTGGTGGGTGACCTTACCGGCAGCAACGATGATCGCCCGTGAAATTATTATTTCTGC
GTTACGCGAATGGATGGCGGAGTTGGGTAAACGCAGTAGCGTGGCTGTCTCCTGGATTGGGAAAGTGAAAACCACTGCCC
AGATGGTGGCGCTGGCCTGGCTGCTGTGGCGTCCGAACATTTGGGTTGAGTACGCCGGTATTGCACTTTTCTTTGTGGCT
GCGGTACTGACTCTGTGGTCAATGTTGCAATATTTGAGCGCTGCGCGTGCAGATTTGCTTGATCAGTGA

Upstream 100 bases:

>100_bases
CGCAAGGTCTGGCAGAAAAGATCTTCTGGTCGTTGAAACATTGATGTCTCTGTAGCAACATAGGGGTAATCTTACTGACA
ACAGATAGTTACCCGTCATT

Downstream 100 bases:

>100_bases
TCGTTTCGGCGCAATTTTCAGCAAACGATCAAAAGTGGTGAAAAATATCGTTGACTCATCGCGCCAGGTAAGTAGAATGC
AACGCATCGAACGGCGGCAC

Product: phosphatidylglycerophosphate synthetase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMV
LVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVA
AVLTLWSMLQYLSAARADLLDQ

Sequences:

>Translated_182_residues
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMV
LVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVA
AVLTLWSMLQYLSAARADLLDQ
>Mature_182_residues
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVLVAIAMV
LVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSSVAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVA
AVLTLWSMLQYLSAARADLLDQ

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Escherichia coli, GI1788220, Length=182, Percent_Identity=100, Blast_Score=360, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA_ECO57 (P0ABG0)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B90960
- PIR:   C85808
- RefSeq:   NP_288373.1
- RefSeq:   NP_310677.1
- ProteinModelPortal:   P0ABG0
- EnsemblBacteria:   EBESCT00000026635
- EnsemblBacteria:   EBESCT00000058874
- GeneID:   913922
- GeneID:   961910
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3000
- KEGG:   ecs:ECs2650
- GeneTree:   EBGT00050000009502
- HOGENOM:   HBG686655
- OMA:   WSYMAAS
- ProtClustDB:   PRK10832
- BioCyc:   ECOL83334:ECS2650-MONOMER
- HAMAP:   MF_01437
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847
- TIGRFAMs:   TIGR00560

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 20701; Mature: 20701

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x213e636c)-; HASH(0x216642a8)-; HASH(0x211d9450)-; HASH(0x1f579ac4)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQST
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARADLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DQ
CH
>Mature Secondary Structure
MQFNIPTLLTLFRVILIPFFVLVFYLPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQST
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RFGAFLDPVADKVLVAIAMVLVTEHYHSWWVTLPAATMIAREIIISALREWMAELGKRSS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VAVSWIGKVKTTAQMVALAWLLWRPNIWVEYAGIALFFVAAVLTLWSMLQYLSAARADLL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DQ
CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796